P15252 (REF_HEVBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Rubber elongation factor protein Short name=REF Alternative name(s): Allergen=Hev b 1
Organism	Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Taxonomic identifier	3981 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Euphorbiaceae › Crotonoideae › Micrandreae › Hevea

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be part of the rubber biosynthesis machinery. Plays a role in rubber elongation.
Subcellular location	Cytoplasm Probable. Note: Tightly bound on latex small rubber particles.
Allergenic properties	Causes an allergic reaction in human. Involved in latex allergic reactions.
Sequence similarities	Belongs to the REF/SRPP family.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Allergen
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 138	137	Rubber elongation factor protein		PRO_0000221060
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P15252 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: BE37206378306306	FASTA	138	14,722
	10 20 30 40 50 60 MAEDEDNQQG QGEGLKYLGF VQDAATYAVT TFSNVYLFAK DKSGPLQPGV DIIEGPVKNV 70 80 90 100 110 120 AVPLYNRFSY IPNGALKFVD STVVASVTII DRSLPPIVKD ASIQVVSAIR AAPEAARSLA 130 SSLPGQTKIL AKVFYGEN

References

[1]	"Molecular cloning and nucleotide sequencing of the rubber elongation factor gene from Hevea brasiliensis." Attanyaka D.P.S.T.G., Kekwick R.G.O., Franklin F.C.H. Plant Mol. Biol. 16:1079-1081(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Laticifer.
[2]	"Amino acid sequence of rubber elongation factor protein associated with rubber particles in Hevea latex." Dennis M.S., Henzel W.J., Kohr W., Light D.R. J. Biol. Chem. 264:18618-18626(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-138.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56535 mRNA. Translation: CAA39880.1.
PIR	A34309. S16258.
3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	3310. Hev b 1.0101. 379. Hev b 1.
Proteomic databases
PRIDE	P15252.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008802. REF. [Graphical view]
Pfam	PF05755. REF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

REF_HEVBR

Accession

Primary (citable) accession number: P15252

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program