ID   IL9_HUMAN               Reviewed;         144 AA.
AC   P15248;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-JAN-2012, entry version 112.
DE   RecName: Full=Interleukin-9;
DE            Short=IL-9;
DE   AltName: Full=Cytokine P40;
DE   AltName: Full=T-cell growth factor P40;
DE   Flags: Precursor;
GN   Name=IL9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90028706; PubMed=2508790;
RA   Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K.,
RA   Clark S.C.;
RT   "Expression cloning of cDNA encoding a novel human hematopoietic
RT   growth factor: human homologue of murine T-cell growth factor P40.";
RL   Blood 74:1880-1884(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=91370669; PubMed=2129501; DOI=10.1016/1043-4666(90)90037-T;
RA   Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.;
RT   "Cloning and expression of a cDNA for the human homolog of mouse T
RT   cell and mast cell growth factor P40.";
RL   Cytokine 2:9-12(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90257340; PubMed=1971295;
RA   Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E.,
RA   van Snick J.;
RT   "Human P40/IL-9. Expression in activated CD4+ T cells, genomic
RT   organization, and comparison with the mouse gene.";
RL   J. Immunol. 144:4235-4241(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Leukocyte;
RX   MEDLINE=91183161; PubMed=1901233;
RA   Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L.,
RA   Chen J.W., Lin P.F., Luo W., Yang Y.C.;
RT   "Human interleukin-9: genomic sequence, chromosomal location, and
RT   sequences essential for its expression in human T-cell leukemia virus
RT   (HTLV)-I-transformed human T cells.";
RL   Blood 77:1436-1441(1991).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MET-117.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Supports IL-2 independent and IL-4 independent growth of
CC       helper T-cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-9 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_9";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il9/";
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DR   EMBL; M30134; AAA36400.1; -; mRNA.
DR   EMBL; X17543; CAA35581.1; -; mRNA.
DR   EMBL; S63356; AAB19823.1; -; mRNA.
DR   EMBL; M30135; AAA35887.1; -; Genomic_DNA.
DR   EMBL; M86593; AAA59161.1; -; Genomic_DNA.
DR   EMBL; AF361105; AAK26666.1; -; Genomic_DNA.
DR   EMBL; AC002428; AAB66904.1; -; Genomic_DNA.
DR   EMBL; AC004763; AAC17735.1; -; Genomic_DNA.
DR   EMBL; BC066283; AAH66283.1; -; mRNA.
DR   EMBL; BC066285; AAH66285.1; -; mRNA.
DR   EMBL; BC066286; AAH66286.1; -; mRNA.
DR   IPI; IPI00010780; -.
DR   PIR; A60480; A60480.
DR   RefSeq; NP_000581.1; NM_000590.1.
DR   UniGene; Hs.960; -.
DR   ProteinModelPortal; P15248; -.
DR   DIP; DIP-3155N; -.
DR   STRING; P15248; -.
DR   PhosphoSite; P15248; -.
DR   DMDM; 124362; -.
DR   PRIDE; P15248; -.
DR   Ensembl; ENST00000274520; ENSP00000274520; ENSG00000145839.
DR   GeneID; 3578; -.
DR   KEGG; hsa:3578; -.
DR   UCSC; uc003lbb.1; human.
DR   CTD; 3578; -.
DR   GeneCards; GC05M135227; -.
DR   H-InvDB; HIX0032077; -.
DR   HGNC; HGNC:6029; IL9.
DR   MIM; 146931; gene.
DR   neXtProt; NX_P15248; -.
DR   PharmGKB; PA29845; -.
DR   eggNOG; prNOG19957; -.
DR   HOGENOM; HBG125274; -.
DR   HOVERGEN; HBG003933; -.
DR   InParanoid; P15248; -.
DR   OMA; KEKMRGM; -.
DR   OrthoDB; EOG476K1P; -.
DR   PhylomeDB; P15248; -.
DR   NextBio; 13986; -.
DR   ArrayExpress; P15248; -.
DR   Bgee; P15248; -.
DR   CleanEx; HS_IL9; -.
DR   Genevestigator; P15248; -.
DR   GermOnline; ENSG00000145839; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; TAS:ProtInc.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
DR   GO; GO:0045407; P:positive regulation of interleukin-5 biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR018049; Interleukin-7/-9_CS.
DR   InterPro; IPR020447; Interleukin-9.
DR   InterPro; IPR000226; Interleukin_7_9.
DR   KO; K05432; -.
DR   Pfam; PF01415; IL7; 1.
DR   PRINTS; PR01926; INTERLEUKIN9.
DR   PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytokine; Glycoprotein; Growth factor;
KW   Polymorphism; Reference proteome; Secreted; Signal.
FT   SIGNAL        1     18
FT   CHAIN        19    144       Interleukin-9.
FT                                /FTId=PRO_0000015627.
FT   CARBOHYD     50     50       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     63     63       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     78     78       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    114    114       N-linked (GlcNAc...) (Potential).
FT   VARIANT     117    117       T -> M (in dbSNP:rs2069885).
FT                                /FTId=VAR_013079.
SQ   SEQUENCE   144 AA;  15909 MW;  2EAA08690558ECAB CRC64;
     MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP
     SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN
     ALTFLKSLLE IFQKEKMRGM RGKI
//