P15248 (IL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-9
Short name=IL-9

Alternative name(s):
Cytokine P40
T-cell growth factor P40

Gene names

Name:

IL9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Supports IL-2 independent and IL-4 independent growth of helper T-cells.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-7/IL-9 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Glycoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro inflammatory response Traceable author statement PubMed 9371819. Source: ProtInc positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Traceable author statement PubMed 1680606. Source: ProtInc positive regulation of interleukin-5 biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18
	Chain	19 – 144	126	Interleukin-9		PRO_0000015627
Amino acid modifications
	Modified residue	19	1	Pyrrolidone carboxylic acid By similarity
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	63	1	N-linked (GlcNAc...) Potential
	Glycosylation	78	1	N-linked (GlcNAc...) Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	117	1	T → M. Ref.5 Corresponds to variant rs2069885 [ dbSNP | Ensembl ].		VAR_013079

Sequences

	Sequence		Length	Mass (Da)
	P15248 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 2EAA08690558ECAB	FASTA	144	15,909
	10 20 30 40 50 60 MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP 70 80 90 100 110 120 SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN 130 140 ALTFLKSLLE IFQKEKMRGM RGKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40." Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K., Clark S.C. Blood 74:1880-1884(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40." Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J. Cytokine 2:9-12(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene." Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J. J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells." Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., Yang Y.C. Blood 77:1436-1441(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Leukocyte.
[5]	SeattleSNPs variation discovery resource Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-117.
[6]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-9 entry

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	M30134 mRNA. Translation: AAA36400.1. X17543 mRNA. Translation: CAA35581.1. S63356 mRNA. Translation: AAB19823.1. M30135 Genomic DNA. Translation: AAA35887.1. M86593 Genomic DNA. Translation: AAA59161.1. AF361105 Genomic DNA. Translation: AAK26666.1. AC002428 Genomic DNA. Translation: AAB66904.1. AC004763 Genomic DNA. Translation: AAC17735.1. BC066283 mRNA. Translation: AAH66283.1. BC066285 mRNA. Translation: AAH66285.1. BC066286 mRNA. Translation: AAH66286.1.
IPI	IPI00010780.
PIR	A60480.
RefSeq	NP_000581.1. NM_000590.1.
UniGene	Hs.960.
3D structure databases
ProteinModelPortal	P15248.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3155N.
STRING	9606.ENSP00000274520.
PTM databases
PhosphoSite	P15248.
Polymorphism databases
DMDM	124362.
Proteomic databases
PaxDb	P15248.
PRIDE	P15248.
Protocols and materials databases
DNASU	3578.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274520; ENSP00000274520; ENSG00000145839.
GeneID	3578.
KEGG	hsa:3578.
UCSC	uc003lbb.1. human.
Organism-specific databases
CTD	3578.
GeneCards	GC05M135227.
HGNC	HGNC:6029. IL9.
MIM	146931. gene.
neXtProt	NX_P15248.
PharmGKB	PA29845.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47015.
HOGENOM	HOG000113052.
HOVERGEN	HBG003933.
InParanoid	P15248.
KO	K05432.
OMA	CLCLPIP.
OrthoDB	EOG476K1P.
PhylomeDB	P15248.
Gene expression databases
Bgee	P15248.
CleanEx	HS_IL9.
Genevestigator	P15248.
GermOnline	ENSG00000145839. Homo sapiens.
Family and domain databases
InterPro	IPR018049. Interleukin-7/-9_CS. IPR020447. Interleukin-9. IPR000226. Interleukin_7_9. [Graphical view]
Pfam	PF01415. IL7. 1 hit. [Graphical view]
PRINTS	PR01926. INTERLEUKIN9.
PROSITE	PS00255. INTERLEUKIN_7_9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3578.
NextBio	13986.
SOURCE	Search...

Entry information

Entry name

IL9_HUMAN

Accession

Primary (citable) accession number: P15248

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 121 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.