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Protein

Interleukin-9

Gene

IL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

GO - Biological processi

  1. immune response Source: InterPro
  2. inflammatory response Source: ProtInc
  3. positive regulation of cell growth Source: Ensembl
  4. positive regulation of cell proliferation Source: ProtInc
  5. positive regulation of interleukin-5 biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

SignaLinkiP15248.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9
Short name:
IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene namesi
Name:IL9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6029. IL9.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29845.

Polymorphism and mutation databases

BioMutaiIL9.
DMDMi124362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 144126Interleukin-9PRO_0000015627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP15248.
PRIDEiP15248.

PTM databases

PhosphoSiteiP15248.

Expressioni

Gene expression databases

BgeeiP15248.
CleanExiHS_IL9.
GenevestigatoriP15248.

Interactioni

Protein-protein interaction databases

BioGridi109792. 1 interaction.
DIPiDIP-3155N.
STRINGi9606.ENSP00000274520.

Structurei

3D structure databases

ProteinModelPortaliP15248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47015.
GeneTreeiENSGT00390000015384.
HOGENOMiHOG000113052.
HOVERGENiHBG003933.
InParanoidiP15248.
KOiK05432.
OMAiNVTDCLC.
OrthoDBiEOG7B05G8.
PhylomeDBiP15248.
TreeFamiTF336367.

Family and domain databases

InterProiIPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view]
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PRINTSiPR01926. INTERLEUKIN9.
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN
60 70 80 90 100
VTSCLCLGIP SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK
110 120 130 140
NNKCPYFSCE QPCNQTTAGN ALTFLKSLLE IFQKEKMRGM RGKI
Length:144
Mass (Da):15,909
Last modified:April 1, 1990 - v1
Checksum:i2EAA08690558ECAB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171T → M.1 Publication
Corresponds to variant rs2069885 [ dbSNP | Ensembl ].
VAR_013079

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30134 mRNA. Translation: AAA36400.1.
X17543 mRNA. Translation: CAA35581.1.
S63356 mRNA. Translation: AAB19823.1.
M30135 Genomic DNA. Translation: AAA35887.1.
M86593 Genomic DNA. Translation: AAA59161.1.
AF361105 Genomic DNA. Translation: AAK26666.1.
AC002428 Genomic DNA. Translation: AAB66904.1.
AC004763 Genomic DNA. Translation: AAC17735.1.
BC066283 mRNA. Translation: AAH66283.1.
BC066285 mRNA. Translation: AAH66285.1.
BC066286 mRNA. Translation: AAH66286.1.
CCDSiCCDS4189.1.
PIRiA60480.
RefSeqiNP_000581.1. NM_000590.1.
UniGeneiHs.960.

Genome annotation databases

EnsembliENST00000274520; ENSP00000274520; ENSG00000145839.
GeneIDi3578.
KEGGihsa:3578.
UCSCiuc003lbb.1. human.

Polymorphism and mutation databases

BioMutaiIL9.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-9 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30134 mRNA. Translation: AAA36400.1.
X17543 mRNA. Translation: CAA35581.1.
S63356 mRNA. Translation: AAB19823.1.
M30135 Genomic DNA. Translation: AAA35887.1.
M86593 Genomic DNA. Translation: AAA59161.1.
AF361105 Genomic DNA. Translation: AAK26666.1.
AC002428 Genomic DNA. Translation: AAB66904.1.
AC004763 Genomic DNA. Translation: AAC17735.1.
BC066283 mRNA. Translation: AAH66283.1.
BC066285 mRNA. Translation: AAH66285.1.
BC066286 mRNA. Translation: AAH66286.1.
CCDSiCCDS4189.1.
PIRiA60480.
RefSeqiNP_000581.1. NM_000590.1.
UniGeneiHs.960.

3D structure databases

ProteinModelPortaliP15248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109792. 1 interaction.
DIPiDIP-3155N.
STRINGi9606.ENSP00000274520.

PTM databases

PhosphoSiteiP15248.

Polymorphism and mutation databases

BioMutaiIL9.
DMDMi124362.

Proteomic databases

PaxDbiP15248.
PRIDEiP15248.

Protocols and materials databases

DNASUi3578.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274520; ENSP00000274520; ENSG00000145839.
GeneIDi3578.
KEGGihsa:3578.
UCSCiuc003lbb.1. human.

Organism-specific databases

CTDi3578.
GeneCardsiGC05M135227.
HGNCiHGNC:6029. IL9.
MIMi146931. gene.
neXtProtiNX_P15248.
PharmGKBiPA29845.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47015.
GeneTreeiENSGT00390000015384.
HOGENOMiHOG000113052.
HOVERGENiHBG003933.
InParanoidiP15248.
KOiK05432.
OMAiNVTDCLC.
OrthoDBiEOG7B05G8.
PhylomeDBiP15248.
TreeFamiTF336367.

Enzyme and pathway databases

SignaLinkiP15248.

Miscellaneous databases

GeneWikiiInterleukin_9.
GenomeRNAii3578.
NextBioi13986.
PROiP15248.
SOURCEiSearch...

Gene expression databases

BgeeiP15248.
CleanExiHS_IL9.
GenevestigatoriP15248.

Family and domain databases

InterProiIPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view]
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PRINTSiPR01926. INTERLEUKIN9.
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40."
    Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K., Clark S.C.
    Blood 74:1880-1884(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40."
    Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.
    Cytokine 2:9-12(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene."
    Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.
    J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells."
    Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., Yang Y.C.
    Blood 77:1436-1441(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leukocyte.
  5. SeattleSNPs variation discovery resource
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-117.
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIL9_HUMAN
AccessioniPrimary (citable) accession number: P15248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 29, 2015
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.