Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P15248

- IL9_HUMAN

UniProt

P15248 - IL9_HUMAN

Protein

Interleukin-9

Gene

IL9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Supports IL-2 independent and IL-4 independent growth of helper T-cells.

    GO - Biological processi

    1. immune response Source: InterPro
    2. inflammatory response Source: ProtInc
    3. positive regulation of cell growth Source: Ensembl
    4. positive regulation of cell proliferation Source: ProtInc
    5. positive regulation of interleukin-5 biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    SignaLinkiP15248.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-9
    Short name:
    IL-9
    Alternative name(s):
    Cytokine P40
    T-cell growth factor P40
    Gene namesi
    Name:IL9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:6029. IL9.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29845.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 144126Interleukin-9PRO_0000015627Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiP15248.
    PRIDEiP15248.

    PTM databases

    PhosphoSiteiP15248.

    Expressioni

    Gene expression databases

    BgeeiP15248.
    CleanExiHS_IL9.
    GenevestigatoriP15248.

    Interactioni

    Protein-protein interaction databases

    BioGridi109792. 1 interaction.
    DIPiDIP-3155N.
    STRINGi9606.ENSP00000274520.

    Structurei

    3D structure databases

    ProteinModelPortaliP15248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-7/IL-9 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47015.
    HOGENOMiHOG000113052.
    HOVERGENiHBG003933.
    InParanoidiP15248.
    KOiK05432.
    OMAiKEKMRGM.
    OrthoDBiEOG7B05G8.
    PhylomeDBiP15248.
    TreeFamiTF336367.

    Family and domain databases

    InterProiIPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    IPR020447. IL-9.
    [Graphical view]
    PfamiPF01415. IL7. 1 hit.
    [Graphical view]
    PRINTSiPR01926. INTERLEUKIN9.
    PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15248-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN    50
    VTSCLCLGIP SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK 100
    NNKCPYFSCE QPCNQTTAGN ALTFLKSLLE IFQKEKMRGM RGKI 144
    Length:144
    Mass (Da):15,909
    Last modified:April 1, 1990 - v1
    Checksum:i2EAA08690558ECAB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171T → M.1 Publication
    Corresponds to variant rs2069885 [ dbSNP | Ensembl ].
    VAR_013079

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30134 mRNA. Translation: AAA36400.1.
    X17543 mRNA. Translation: CAA35581.1.
    S63356 mRNA. Translation: AAB19823.1.
    M30135 Genomic DNA. Translation: AAA35887.1.
    M86593 Genomic DNA. Translation: AAA59161.1.
    AF361105 Genomic DNA. Translation: AAK26666.1.
    AC002428 Genomic DNA. Translation: AAB66904.1.
    AC004763 Genomic DNA. Translation: AAC17735.1.
    BC066283 mRNA. Translation: AAH66283.1.
    BC066285 mRNA. Translation: AAH66285.1.
    BC066286 mRNA. Translation: AAH66286.1.
    CCDSiCCDS4189.1.
    PIRiA60480.
    RefSeqiNP_000581.1. NM_000590.1.
    UniGeneiHs.960.

    Genome annotation databases

    EnsembliENST00000274520; ENSP00000274520; ENSG00000145839.
    GeneIDi3578.
    KEGGihsa:3578.
    UCSCiuc003lbb.1. human.

    Polymorphism databases

    DMDMi124362.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-9 entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30134 mRNA. Translation: AAA36400.1 .
    X17543 mRNA. Translation: CAA35581.1 .
    S63356 mRNA. Translation: AAB19823.1 .
    M30135 Genomic DNA. Translation: AAA35887.1 .
    M86593 Genomic DNA. Translation: AAA59161.1 .
    AF361105 Genomic DNA. Translation: AAK26666.1 .
    AC002428 Genomic DNA. Translation: AAB66904.1 .
    AC004763 Genomic DNA. Translation: AAC17735.1 .
    BC066283 mRNA. Translation: AAH66283.1 .
    BC066285 mRNA. Translation: AAH66285.1 .
    BC066286 mRNA. Translation: AAH66286.1 .
    CCDSi CCDS4189.1.
    PIRi A60480.
    RefSeqi NP_000581.1. NM_000590.1.
    UniGenei Hs.960.

    3D structure databases

    ProteinModelPortali P15248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109792. 1 interaction.
    DIPi DIP-3155N.
    STRINGi 9606.ENSP00000274520.

    PTM databases

    PhosphoSitei P15248.

    Polymorphism databases

    DMDMi 124362.

    Proteomic databases

    PaxDbi P15248.
    PRIDEi P15248.

    Protocols and materials databases

    DNASUi 3578.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274520 ; ENSP00000274520 ; ENSG00000145839 .
    GeneIDi 3578.
    KEGGi hsa:3578.
    UCSCi uc003lbb.1. human.

    Organism-specific databases

    CTDi 3578.
    GeneCardsi GC05M135227.
    HGNCi HGNC:6029. IL9.
    MIMi 146931. gene.
    neXtProti NX_P15248.
    PharmGKBi PA29845.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47015.
    HOGENOMi HOG000113052.
    HOVERGENi HBG003933.
    InParanoidi P15248.
    KOi K05432.
    OMAi KEKMRGM.
    OrthoDBi EOG7B05G8.
    PhylomeDBi P15248.
    TreeFami TF336367.

    Enzyme and pathway databases

    SignaLinki P15248.

    Miscellaneous databases

    GeneWikii Interleukin_9.
    GenomeRNAii 3578.
    NextBioi 13986.
    PROi P15248.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15248.
    CleanExi HS_IL9.
    Genevestigatori P15248.

    Family and domain databases

    InterProi IPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    IPR020447. IL-9.
    [Graphical view ]
    Pfami PF01415. IL7. 1 hit.
    [Graphical view ]
    PRINTSi PR01926. INTERLEUKIN9.
    PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40."
      Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K., Clark S.C.
      Blood 74:1880-1884(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40."
      Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.
      Cytokine 2:9-12(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene."
      Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.
      J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells."
      Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., Yang Y.C.
      Blood 77:1436-1441(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leukocyte.
    5. SeattleSNPs variation discovery resource
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-117.
    6. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiIL9_HUMAN
    AccessioniPrimary (citable) accession number: P15248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3