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P15248 (IL9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-9

Short name=IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene names
Name:IL9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-7/IL-9 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 144126Interleukin-9
PRO_0000015627

Amino acid modifications

Modified residue191Pyrrolidone carboxylic acid By similarity
Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation781N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential

Natural variations

Natural variant1171T → M. Ref.5
Corresponds to variant rs2069885 [ dbSNP | Ensembl ].
VAR_013079

Sequences

Sequence LengthMass (Da)Tools
P15248 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 2EAA08690558ECAB

FASTA14415,909
        10         20         30         40         50         60 
MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP 

        70         80         90        100        110        120 
SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN 

       130        140 
ALTFLKSLLE IFQKEKMRGM RGKI 

« Hide

References

« Hide 'large scale' references
[1]"Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40."
Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K., Clark S.C.
Blood 74:1880-1884(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40."
Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.
Cytokine 2:9-12(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene."
Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.
J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells."
Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., Yang Y.C.
Blood 77:1436-1441(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Leukocyte.
[5]SeattleSNPs variation discovery resource
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-117.
[6]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-9 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M30134 mRNA. Translation: AAA36400.1.
X17543 mRNA. Translation: CAA35581.1.
S63356 mRNA. Translation: AAB19823.1.
M30135 Genomic DNA. Translation: AAA35887.1.
M86593 Genomic DNA. Translation: AAA59161.1.
AF361105 Genomic DNA. Translation: AAK26666.1.
AC002428 Genomic DNA. Translation: AAB66904.1.
AC004763 Genomic DNA. Translation: AAC17735.1.
BC066283 mRNA. Translation: AAH66283.1.
BC066285 mRNA. Translation: AAH66285.1.
BC066286 mRNA. Translation: AAH66286.1.
PIRA60480.
RefSeqNP_000581.1. NM_000590.1.
UniGeneHs.960.

3D structure databases

ProteinModelPortalP15248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109792. 1 interaction.
DIPDIP-3155N.
STRING9606.ENSP00000274520.

PTM databases

PhosphoSiteP15248.

Polymorphism databases

DMDM124362.

Proteomic databases

PaxDbP15248.
PRIDEP15248.

Protocols and materials databases

DNASU3578.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274520; ENSP00000274520; ENSG00000145839.
GeneID3578.
KEGGhsa:3578.
UCSCuc003lbb.1. human.

Organism-specific databases

CTD3578.
GeneCardsGC05M135227.
HGNCHGNC:6029. IL9.
MIM146931. gene.
neXtProtNX_P15248.
PharmGKBPA29845.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47015.
HOGENOMHOG000113052.
HOVERGENHBG003933.
InParanoidP15248.
KOK05432.
OMATDCLCLP.
OrthoDBEOG7B05G8.
PhylomeDBP15248.
TreeFamTF336367.

Enzyme and pathway databases

SignaLinkP15248.

Gene expression databases

BgeeP15248.
CleanExHS_IL9.
GenevestigatorP15248.

Family and domain databases

InterProIPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view]
PfamPF01415. IL7. 1 hit.
[Graphical view]
PRINTSPR01926. INTERLEUKIN9.
PROSITEPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiInterleukin_9.
GenomeRNAi3578.
NextBio13986.
PROP15248.
SOURCESearch...

Entry information

Entry nameIL9_HUMAN
AccessionPrimary (citable) accession number: P15248
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 19, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM