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P15247

- IL9_MOUSE

UniProt

P15247 - IL9_MOUSE

Protein

Interleukin-9

Gene

Il9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Supports IL-2 independent and IL-4 independent growth of helper T-cells.

    GO - Biological processi

    1. immune response Source: InterPro
    2. positive regulation of cell growth Source: Ensembl
    3. positive regulation of interleukin-5 biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-9
    Short name:
    IL-9
    Alternative name(s):
    Cytokine P40
    T-cell growth factor P40
    Gene namesi
    Name:Il9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:96563. Il9.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 144126Interleukin-9PRO_0000015628Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Pyrrolidone carboxylic acid1 Publication
    Glycosylationi50 – 501N-linked (GlcNAc...)1 Publication
    Glycosylationi78 – 781N-linked (GlcNAc...)1 Publication
    Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication
    Glycosylationi114 – 1141N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiP15247.

    PTM databases

    PhosphoSiteiP15247.

    Expressioni

    Gene expression databases

    BgeeiP15247.
    CleanExiMM_IL9.
    GenevestigatoriP15247.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022019.

    Structurei

    3D structure databases

    ProteinModelPortaliP15247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-7/IL-9 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47015.
    GeneTreeiENSGT00390000015384.
    HOGENOMiHOG000113052.
    HOVERGENiHBG003933.
    InParanoidiP15247.
    KOiK05432.
    OMAiKEKMRGM.
    OrthoDBiEOG7B05G8.
    PhylomeDBiP15247.
    TreeFamiTF336367.

    Family and domain databases

    InterProiIPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    IPR020447. IL-9.
    [Graphical view]
    PfamiPF01415. IL7. 1 hit.
    [Graphical view]
    PRINTSiPR01926. INTERLEUKIN9.
    PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15247-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN    50
    VTSCLCLSVP TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK 100
    NITCPSFSCE KPCNQTMAGN TLSFLKSLLG TFQKTEMQRQ KSRP 144
    Length:144
    Mass (Da):16,075
    Last modified:April 1, 1990 - v1
    Checksum:iECD944632CE837C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14045 mRNA. Translation: CAA32203.1.
    M30136 Genomic DNA. Translation: AAA39874.1.
    CCDSiCCDS26562.1.
    PIRiJL0089.
    RefSeqiNP_032399.1. NM_008373.1.
    UniGeneiMm.3006.

    Genome annotation databases

    EnsembliENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538.
    GeneIDi16198.
    KEGGimmu:16198.
    UCSCiuc007qso.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14045 mRNA. Translation: CAA32203.1 .
    M30136 Genomic DNA. Translation: AAA39874.1 .
    CCDSi CCDS26562.1.
    PIRi JL0089.
    RefSeqi NP_032399.1. NM_008373.1.
    UniGenei Mm.3006.

    3D structure databases

    ProteinModelPortali P15247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022019.

    PTM databases

    PhosphoSitei P15247.

    Proteomic databases

    PRIDEi P15247.

    Protocols and materials databases

    DNASUi 16198.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022019 ; ENSMUSP00000022019 ; ENSMUSG00000021538 .
    GeneIDi 16198.
    KEGGi mmu:16198.
    UCSCi uc007qso.1. mouse.

    Organism-specific databases

    CTDi 3578.
    MGIi MGI:96563. Il9.

    Phylogenomic databases

    eggNOGi NOG47015.
    GeneTreei ENSGT00390000015384.
    HOGENOMi HOG000113052.
    HOVERGENi HBG003933.
    InParanoidi P15247.
    KOi K05432.
    OMAi KEKMRGM.
    OrthoDBi EOG7B05G8.
    PhylomeDBi P15247.
    TreeFami TF336367.

    Miscellaneous databases

    NextBioi 289129.
    PROi P15247.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15247.
    CleanExi MM_IL9.
    Genevestigatori P15247.

    Family and domain databases

    InterProi IPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    IPR020447. IL-9.
    [Graphical view ]
    Pfami PF01415. IL7. 1 hit.
    [Graphical view ]
    PRINTSi PR01926. INTERLEUKIN9.
    PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)."
      van Snick J., Goethals A., Renauld J.-C., van Roost E., Uyttenhove C., Rubira M.R., Moritz R.L., Simpson R.J.
      J. Exp. Med. 169:363-368(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene."
      Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.
      J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete amino acid sequence of a new murine T-cell growth factor P40."
      Simpson R.J., Moritz R.L., Rubira M.R., Gorman J.J., van Snick J.
      Eur. J. Biochem. 183:715-722(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 19-144, PYROGLUTAMATE FORMATION AT GLN-19, GLYCOSYLATION AT ASN-50; ASN-78; ASN-101 AND ASN-114.
    4. "Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity."
      Uyttenhove C., Simpson R.J., van Snick J.
      Proc. Natl. Acad. Sci. U.S.A. 85:6934-6938(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 118-136.

    Entry informationi

    Entry nameiIL9_MOUSE
    AccessioniPrimary (citable) accession number: P15247
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3