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Protein

Interleukin-9

Gene

Il9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

GO - Biological processi

  1. immune response Source: InterPro
  2. positive regulation of cell growth Source: Ensembl
  3. positive regulation of interleukin-5 biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9
Short name:
IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene namesi
Name:Il9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96563. Il9.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 144126Interleukin-9PRO_0000015628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acid1 Publication
Glycosylationi50 – 501N-linked (GlcNAc...)1 Publication
Glycosylationi78 – 781N-linked (GlcNAc...)1 Publication
Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication
Glycosylationi114 – 1141N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP15247.

PTM databases

PhosphoSiteiP15247.

Expressioni

Gene expression databases

BgeeiP15247.
CleanExiMM_IL9.
GenevestigatoriP15247.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022019.

Structurei

3D structure databases

ProteinModelPortaliP15247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47015.
GeneTreeiENSGT00390000015384.
HOGENOMiHOG000113052.
HOVERGENiHBG003933.
InParanoidiP15247.
KOiK05432.
OMAiNVTDCLC.
OrthoDBiEOG7B05G8.
PhylomeDBiP15247.
TreeFamiTF336367.

Family and domain databases

InterProiIPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view]
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PRINTSiPR01926. INTERLEUKIN9.
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN
60 70 80 90 100
VTSCLCLSVP TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK
110 120 130 140
NITCPSFSCE KPCNQTMAGN TLSFLKSLLG TFQKTEMQRQ KSRP
Length:144
Mass (Da):16,075
Last modified:April 1, 1990 - v1
Checksum:iECD944632CE837C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14045 mRNA. Translation: CAA32203.1.
M30136 Genomic DNA. Translation: AAA39874.1.
CCDSiCCDS26562.1.
PIRiJL0089.
RefSeqiNP_032399.1. NM_008373.1.
UniGeneiMm.3006.

Genome annotation databases

EnsembliENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538.
GeneIDi16198.
KEGGimmu:16198.
UCSCiuc007qso.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14045 mRNA. Translation: CAA32203.1.
M30136 Genomic DNA. Translation: AAA39874.1.
CCDSiCCDS26562.1.
PIRiJL0089.
RefSeqiNP_032399.1. NM_008373.1.
UniGeneiMm.3006.

3D structure databases

ProteinModelPortaliP15247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022019.

PTM databases

PhosphoSiteiP15247.

Proteomic databases

PRIDEiP15247.

Protocols and materials databases

DNASUi16198.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538.
GeneIDi16198.
KEGGimmu:16198.
UCSCiuc007qso.1. mouse.

Organism-specific databases

CTDi3578.
MGIiMGI:96563. Il9.

Phylogenomic databases

eggNOGiNOG47015.
GeneTreeiENSGT00390000015384.
HOGENOMiHOG000113052.
HOVERGENiHBG003933.
InParanoidiP15247.
KOiK05432.
OMAiNVTDCLC.
OrthoDBiEOG7B05G8.
PhylomeDBiP15247.
TreeFamiTF336367.

Miscellaneous databases

NextBioi289129.
PROiP15247.
SOURCEiSearch...

Gene expression databases

BgeeiP15247.
CleanExiMM_IL9.
GenevestigatoriP15247.

Family and domain databases

InterProiIPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view]
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PRINTSiPR01926. INTERLEUKIN9.
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)."
    van Snick J., Goethals A., Renauld J.-C., van Roost E., Uyttenhove C., Rubira M.R., Moritz R.L., Simpson R.J.
    J. Exp. Med. 169:363-368(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene."
    Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.
    J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete amino acid sequence of a new murine T-cell growth factor P40."
    Simpson R.J., Moritz R.L., Rubira M.R., Gorman J.J., van Snick J.
    Eur. J. Biochem. 183:715-722(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-144, PYROGLUTAMATE FORMATION AT GLN-19, GLYCOSYLATION AT ASN-50; ASN-78; ASN-101 AND ASN-114.
  4. "Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity."
    Uyttenhove C., Simpson R.J., van Snick J.
    Proc. Natl. Acad. Sci. U.S.A. 85:6934-6938(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 118-136.

Entry informationi

Entry nameiIL9_MOUSE
AccessioniPrimary (citable) accession number: P15247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: January 7, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.