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Protein

Interleukin-9

Gene

Il9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

GO - Molecular functioni

GO - Biological processi

  • immune response Source: InterPro
  • positive regulation of cell growth Source: Ensembl
  • positive regulation of interleukin-5 biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-8985947. Interleukin-9 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9
Short name:
IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene namesi
Name:Il9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96563. Il9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001562819 – 144Interleukin-9Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Glycosylationi50N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi78N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi114N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP15247.
PRIDEiP15247.

PTM databases

PhosphoSitePlusiP15247.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021538.
CleanExiMM_IL9.
GenevisibleiP15247. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022019.

Structurei

3D structure databases

ProteinModelPortaliP15247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYR9. Eukaryota.
ENOG41114M6. LUCA.
GeneTreeiENSGT00390000015384.
HOGENOMiHOG000113052.
HOVERGENiHBG003933.
InParanoidiP15247.
KOiK05432.
OMAiFSCEQPC.
OrthoDBiEOG091G0U4U.
PhylomeDBiP15247.
TreeFamiTF336367.

Family and domain databases

InterProiView protein in InterPro
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
PANTHERiPTHR16926:SF2. PTHR16926:SF2. 1 hit.
PfamiView protein in Pfam
PF01415. IL7. 1 hit.
PRINTSiPR01926. INTERLEUKIN9.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD033324. PD033324. 1 hit.
PROSITEiView protein in PROSITE
PS00255. INTERLEUKIN_7_9. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN
60 70 80 90 100
VTSCLCLSVP TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK
110 120 130 140
NITCPSFSCE KPCNQTMAGN TLSFLKSLLG TFQKTEMQRQ KSRP
Length:144
Mass (Da):16,075
Last modified:April 1, 1990 - v1
Checksum:iECD944632CE837C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14045 mRNA. Translation: CAA32203.1.
M30136 Genomic DNA. Translation: AAA39874.1.
CCDSiCCDS26562.1.
PIRiJL0089.
RefSeqiNP_032399.1. NM_008373.1.
UniGeneiMm.3006.

Genome annotation databases

EnsembliENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538.
GeneIDi16198.
KEGGimmu:16198.
UCSCiuc007qso.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiIL9_MOUSE
AccessioniPrimary (citable) accession number: P15247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families