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P15247

- IL9_MOUSE

UniProt

P15247 - IL9_MOUSE

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Protein
Interleukin-9
Gene
Il9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

GO - Biological processi

  1. immune response Source: InterPro
  2. positive regulation of cell growth Source: Ensembl
  3. positive regulation of interleukin-5 biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9
Short name:
IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene namesi
Name:Il9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:96563. Il9.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 Publication
Add
BLAST
Chaini19 – 144126Interleukin-9
PRO_0000015628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acid
Glycosylationi50 – 501N-linked (GlcNAc...)1 Publication
Glycosylationi78 – 781N-linked (GlcNAc...)1 Publication
Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication
Glycosylationi114 – 1141N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiP15247.

PTM databases

PhosphoSiteiP15247.

Expressioni

Gene expression databases

BgeeiP15247.
CleanExiMM_IL9.
GenevestigatoriP15247.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022019.

Structurei

3D structure databases

ProteinModelPortaliP15247.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47015.
GeneTreeiENSGT00390000015384.
HOGENOMiHOG000113052.
HOVERGENiHBG003933.
InParanoidiP15247.
KOiK05432.
OMAiKEKMRGM.
OrthoDBiEOG7B05G8.
PhylomeDBiP15247.
TreeFamiTF336367.

Family and domain databases

InterProiIPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view]
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PRINTSiPR01926. INTERLEUKIN9.
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15247-1 [UniParc]FASTAAdd to Basket

« Hide

MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN    50
VTSCLCLSVP TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK 100
NITCPSFSCE KPCNQTMAGN TLSFLKSLLG TFQKTEMQRQ KSRP 144
Length:144
Mass (Da):16,075
Last modified:April 1, 1990 - v1
Checksum:iECD944632CE837C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14045 mRNA. Translation: CAA32203.1.
M30136 Genomic DNA. Translation: AAA39874.1.
CCDSiCCDS26562.1.
PIRiJL0089.
RefSeqiNP_032399.1. NM_008373.1.
UniGeneiMm.3006.

Genome annotation databases

EnsembliENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538.
GeneIDi16198.
KEGGimmu:16198.
UCSCiuc007qso.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14045 mRNA. Translation: CAA32203.1 .
M30136 Genomic DNA. Translation: AAA39874.1 .
CCDSi CCDS26562.1.
PIRi JL0089.
RefSeqi NP_032399.1. NM_008373.1.
UniGenei Mm.3006.

3D structure databases

ProteinModelPortali P15247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022019.

PTM databases

PhosphoSitei P15247.

Proteomic databases

PRIDEi P15247.

Protocols and materials databases

DNASUi 16198.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022019 ; ENSMUSP00000022019 ; ENSMUSG00000021538 .
GeneIDi 16198.
KEGGi mmu:16198.
UCSCi uc007qso.1. mouse.

Organism-specific databases

CTDi 3578.
MGIi MGI:96563. Il9.

Phylogenomic databases

eggNOGi NOG47015.
GeneTreei ENSGT00390000015384.
HOGENOMi HOG000113052.
HOVERGENi HBG003933.
InParanoidi P15247.
KOi K05432.
OMAi KEKMRGM.
OrthoDBi EOG7B05G8.
PhylomeDBi P15247.
TreeFami TF336367.

Miscellaneous databases

NextBioi 289129.
PROi P15247.
SOURCEi Search...

Gene expression databases

Bgeei P15247.
CleanExi MM_IL9.
Genevestigatori P15247.

Family and domain databases

InterProi IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view ]
Pfami PF01415. IL7. 1 hit.
[Graphical view ]
PRINTSi PR01926. INTERLEUKIN9.
PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)."
    van Snick J., Goethals A., Renauld J.-C., van Roost E., Uyttenhove C., Rubira M.R., Moritz R.L., Simpson R.J.
    J. Exp. Med. 169:363-368(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene."
    Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.
    J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete amino acid sequence of a new murine T-cell growth factor P40."
    Simpson R.J., Moritz R.L., Rubira M.R., Gorman J.J., van Snick J.
    Eur. J. Biochem. 183:715-722(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-144, PYROGLUTAMATE FORMATION AT GLN-19, GLYCOSYLATION AT ASN-50; ASN-78; ASN-101 AND ASN-114.
  4. "Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity."
    Uyttenhove C., Simpson R.J., van Snick J.
    Proc. Natl. Acad. Sci. U.S.A. 85:6934-6938(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 118-136.

Entry informationi

Entry nameiIL9_MOUSE
AccessioniPrimary (citable) accession number: P15247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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