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P15247 (IL9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-9

Short name=IL-9
Alternative name(s):
Cytokine P40
T-cell growth factor P40
Gene names
Name:Il9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Supports IL-2 independent and IL-4 independent growth of helper T-cells.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-7/IL-9 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.3
Chain19 – 144126Interleukin-9
PRO_0000015628

Amino acid modifications

Modified residue191Pyrrolidone carboxylic acid
Glycosylation501N-linked (GlcNAc...) Ref.3
Glycosylation781N-linked (GlcNAc...) Ref.3
Glycosylation1011N-linked (GlcNAc...) Ref.3
Glycosylation1141N-linked (GlcNAc...) Ref.3

Sequences

Sequence LengthMass (Da)Tools
P15247 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: ECD944632CE837C7

FASTA14416,075
        10         20         30         40         50         60 
MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN VTSCLCLSVP 

        70         80         90        100        110        120 
TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK NITCPSFSCE KPCNQTMAGN 

       130        140 
TLSFLKSLLG TFQKTEMQRQ KSRP 

« Hide

References

[1]"Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)."
van Snick J., Goethals A., Renauld J.-C., van Roost E., Uyttenhove C., Rubira M.R., Moritz R.L., Simpson R.J.
J. Exp. Med. 169:363-368(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene."
Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.
J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete amino acid sequence of a new murine T-cell growth factor P40."
Simpson R.J., Moritz R.L., Rubira M.R., Gorman J.J., van Snick J.
Eur. J. Biochem. 183:715-722(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 19-144, PYROGLUTAMATE FORMATION AT GLN-19, GLYCOSYLATION AT ASN-50; ASN-78; ASN-101 AND ASN-114.
[4]"Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity."
Uyttenhove C., Simpson R.J., van Snick J.
Proc. Natl. Acad. Sci. U.S.A. 85:6934-6938(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 118-136.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14045 mRNA. Translation: CAA32203.1.
M30136 Genomic DNA. Translation: AAA39874.1.
PIRJL0089.
RefSeqNP_032399.1. NM_008373.1.
UniGeneMm.3006.

3D structure databases

ProteinModelPortalP15247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022019.

PTM databases

PhosphoSiteP15247.

Proteomic databases

PRIDEP15247.

Protocols and materials databases

DNASU16198.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538.
GeneID16198.
KEGGmmu:16198.
UCSCuc007qso.1. mouse.

Organism-specific databases

CTD3578.
MGIMGI:96563. Il9.

Phylogenomic databases

eggNOGNOG47015.
GeneTreeENSGT00390000015384.
HOGENOMHOG000113052.
HOVERGENHBG003933.
InParanoidP15247.
KOK05432.
OMATDCLCLP.
OrthoDBEOG7B05G8.
PhylomeDBP15247.
TreeFamTF336367.

Gene expression databases

BgeeP15247.
CleanExMM_IL9.
GenevestigatorP15247.

Family and domain databases

InterProIPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
IPR020447. IL-9.
[Graphical view]
PfamPF01415. IL7. 1 hit.
[Graphical view]
PRINTSPR01926. INTERLEUKIN9.
PROSITEPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289129.
PROP15247.
SOURCESearch...

Entry information

Entry nameIL9_MOUSE
AccessionPrimary (citable) accession number: P15247
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot