P15247 (IL9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-9
Short name=IL-9

Alternative name(s):
Cytokine P40
T-cell growth factor P40

Gene names

Name:

Il9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Supports IL-2 independent and IL-4 independent growth of helper T-cells.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-7/IL-9 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Glycoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of interleukin-5 biosynthetic process Inferred from mutant phenotype PubMed 16266865. Source: UniProtKB
Cellular_component	extracellular space Inferred from direct assay PubMed 18997793. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Ref.3
	Chain	19 – 144	126	Interleukin-9		PRO_0000015628
Amino acid modifications
	Modified residue	19	1	Pyrrolidone carboxylic acid
	Glycosylation	50	1	N-linked (GlcNAc...) Ref.3
	Glycosylation	78	1	N-linked (GlcNAc...) Ref.3
	Glycosylation	101	1	N-linked (GlcNAc...) Ref.3
	Glycosylation	114	1	N-linked (GlcNAc...) Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P15247 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: ECD944632CE837C7	FASTA	144	16,075
	10 20 30 40 50 60 MLVTYILASV LLFSSVLGQR CSTTWGIRDT NYLIENLKDD PPSKCSCSGN VTSCLCLSVP 70 80 90 100 110 120 TDDCTTPCYR EGLLQLTNAT QKSRLLPVFH RVKRIVEVLK NITCPSFSCE KPCNQTMAGN 130 140 TLSFLKSLLG TFQKTEMQRQ KSRP

References

[1]	"Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40)." van Snick J., Goethals A., Renauld J.-C., van Roost E., Uyttenhove C., Rubira M.R., Moritz R.L., Simpson R.J. J. Exp. Med. 169:363-368(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[2]	"Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene." Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J. J. Immunol. 144:4235-4241(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete amino acid sequence of a new murine T-cell growth factor P40." Simpson R.J., Moritz R.L., Rubira M.R., Gorman J.J., van Snick J. Eur. J. Biochem. 183:715-722(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 19-144, PYROGLUTAMATE FORMATION AT GLN-19, GLYCOSYLATION AT ASN-50; ASN-78; ASN-101 AND ASN-114.
[4]	"Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity." Uyttenhove C., Simpson R.J., van Snick J. Proc. Natl. Acad. Sci. U.S.A. 85:6934-6938(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 118-136.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14045 mRNA. Translation: CAA32203.1. M30136 Genomic DNA. Translation: AAA39874.1.
IPI	IPI00128465.
PIR	JL0089.
RefSeq	NP_032399.1. NM_008373.1.
UniGene	Mm.3006.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000022019.
PTM databases
PhosphoSite	P15247.
Proteomic databases
PRIDE	P15247.
Protocols and materials databases
DNASU	16198.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022019; ENSMUSP00000022019; ENSMUSG00000021538.
GeneID	16198.
KEGG	mmu:16198.
UCSC	uc007qso.1. mouse.
Organism-specific databases
CTD	3578.
MGI	MGI:96563. Il9.
Phylogenomic databases
eggNOG	NOG47015.
GeneTree	ENSGT00390000015384.
HOGENOM	HOG000113052.
HOVERGEN	HBG003933.
InParanoid	P15247.
KO	K05432.
OMA	CLCLPIP.
OrthoDB	EOG476K1P.
Gene expression databases
Bgee	P15247.
CleanEx	MM_IL9.
Genevestigator	P15247.
GermOnline	ENSMUSG00000021538. Mus musculus.
Family and domain databases
InterPro	IPR018049. Interleukin-7/-9_CS. IPR020447. Interleukin-9. IPR000226. Interleukin_7_9. [Graphical view]
Pfam	PF01415. IL7. 1 hit. [Graphical view]
PRINTS	PR01926. INTERLEUKIN9.
PROSITE	PS00255. INTERLEUKIN_7_9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289129.
SOURCE	Search...

Entry information

Entry name

IL9_MOUSE

Accession

Primary (citable) accession number: P15247

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program