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Protein

Staphylokinase

Gene

sak

Organism
Staphylococcus phage 42D (Bacteriophage P42D)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1:1 complex with plasmin, which in turn activates other plasminogen molecules.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Plasminogen activation

Names & Taxonomyi

Protein namesi
Recommended name:
Staphylokinase
Alternative name(s):
Sak42D
Gene namesi
Name:sak
OrganismiStaphylococcus phage 42D (Bacteriophage P42D)
Taxonomic identifieri10715 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
Virus hostiStaphylococcus aureus [TaxID: 1280]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000003160528 – 163StaphylokinaseAdd BLAST136

Structurei

Secondary structure

1163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi51 – 54Combined sources4
Beta strandi57 – 59Combined sources3
Beta strandi61 – 63Combined sources3
Beta strandi65 – 67Combined sources3
Beta strandi72 – 75Combined sources4
Helixi84 – 98Combined sources15
Beta strandi105 – 107Combined sources3
Beta strandi114 – 120Combined sources7
Turni121 – 124Combined sources4
Beta strandi125 – 131Combined sources7
Turni144 – 146Combined sources3
Beta strandi151 – 154Combined sources4
Beta strandi157 – 160Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BUIX-ray2.65C38-163[»]
ProteinModelPortaliP15240.
SMRiP15240.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15240.

Family & Domainsi

Sequence similaritiesi

Belongs to the staphylokinase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR004093. SAK/SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 1 hit.
[Graphical view]
SUPFAMiSSF54328. SSF54328. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRSLLFLT VLLLLFSFSS ITNEVSASSS FDKGKYKKGD DASYFEPTGP
60 70 80 90 100
YLMVNVTGVD GKRNELLSPR YVEFPIKPGT TLTKEKIEYY VEWALDATAY
110 120 130 140 150
KEFRVVELDP SAKIEVTYYD KNKKKEETKS FPITEKGFVV PDLSEHIKNP
160
GFNLITKVVI EKK
Length:163
Mass (Da):18,608
Last modified:April 1, 1990 - v1
Checksum:iAA267A4FF75D36EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06603 Genomic DNA. Translation: CAA29822.1.
M57455 Genomic DNA. Translation: AAA98206.1.
PIRiS02330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06603 Genomic DNA. Translation: CAA29822.1.
M57455 Genomic DNA. Translation: AAA98206.1.
PIRiS02330.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BUIX-ray2.65C38-163[»]
ProteinModelPortaliP15240.
SMRiP15240.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP15240.

Family and domain databases

InterProiIPR004093. SAK/SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 1 hit.
[Graphical view]
SUPFAMiSSF54328. SSF54328. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSAK_BPP42
AccessioniPrimary (citable) accession number: P15240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.