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Protein

Staphylokinase

Gene

sak

Organism
Staphylococcus phage 42D (Bacteriophage P42D)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1:1 complex with plasmin, which in turn activates other plasminogen molecules.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Plasminogen activation

Names & Taxonomyi

Protein namesi
Recommended name:
Staphylokinase
Alternative name(s):
Sak42D
Gene namesi
Name:sak
OrganismiStaphylococcus phage 42D (Bacteriophage P42D)
Taxonomic identifieri10715 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesSiphoviridae
Virus hostiStaphylococcus aureus [TaxID: 1280]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 163136StaphylokinasePRO_0000031605Add
BLAST

Structurei

Secondary structure

1
163
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 544Combined sources
Beta strandi57 – 593Combined sources
Beta strandi61 – 633Combined sources
Beta strandi65 – 673Combined sources
Beta strandi72 – 754Combined sources
Helixi84 – 9815Combined sources
Beta strandi105 – 1073Combined sources
Beta strandi114 – 1207Combined sources
Turni121 – 1244Combined sources
Beta strandi125 – 1317Combined sources
Turni144 – 1463Combined sources
Beta strandi151 – 1544Combined sources
Beta strandi157 – 1604Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BUIX-ray2.65C38-163[»]
ProteinModelPortaliP15240.
SMRiP15240. Positions 28-163.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15240.

Family & Domainsi

Sequence similaritiesi

Belongs to the staphylokinase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR004093. SAK/SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 1 hit.
[Graphical view]
SUPFAMiSSF54328. SSF54328. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRSLLFLT VLLLLFSFSS ITNEVSASSS FDKGKYKKGD DASYFEPTGP
60 70 80 90 100
YLMVNVTGVD GKRNELLSPR YVEFPIKPGT TLTKEKIEYY VEWALDATAY
110 120 130 140 150
KEFRVVELDP SAKIEVTYYD KNKKKEETKS FPITEKGFVV PDLSEHIKNP
160
GFNLITKVVI EKK
Length:163
Mass (Da):18,608
Last modified:April 1, 1990 - v1
Checksum:iAA267A4FF75D36EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06603 Genomic DNA. Translation: CAA29822.1.
M57455 Genomic DNA. Translation: AAA98206.1.
PIRiS02330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06603 Genomic DNA. Translation: CAA29822.1.
M57455 Genomic DNA. Translation: AAA98206.1.
PIRiS02330.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BUIX-ray2.65C38-163[»]
ProteinModelPortaliP15240.
SMRiP15240. Positions 28-163.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP15240.

Family and domain databases

InterProiIPR004093. SAK/SK.
[Graphical view]
PfamiPF02821. Staphylokinase. 1 hit.
[Graphical view]
SUPFAMiSSF54328. SSF54328. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSAK_BPP42
AccessioniPrimary (citable) accession number: P15240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 14, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.