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Protein

Peroxisomal catalase A

Gene

CTA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Miscellaneous

This is one of two catalases in S.cerevisiae; the other is catalase T, which is the cytoplasmic form.
Present with 623 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

heme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei701 Publication1
Active sitei1431 Publication1
Metal bindingi355Iron (heme axial ligand)1 Publication1

GO - Molecular functioni

  • catalase activity Source: SGD
  • heme binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • age-dependent response to reactive oxygen species Source: SGD
  • hydrogen peroxide catabolic process Source: SGD
  • response to hydrogen peroxide Source: GO_Central
  • response to reactive oxygen species Source: SGD

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:YDR256C-MONOMER
ReactomeiR-SCE-3299685 Detoxification of Reactive Oxygen Species
R-SCE-6798695 Neutrophil degranulation
R-SCE-9033241 Peroxisomal protein import

Protein family/group databases

PeroxiBasei5175 SceKat01

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal catalase A (EC:1.11.1.6)
Gene namesi
Name:CTA1
Ordered Locus Names:YDR256C
ORF Names:YD9320A.06C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR256C
SGDiS000002664 CTA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000849282 – 515Peroxisomal catalase AAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP15202
PRIDEiP15202

PTM databases

iPTMnetiP15202

Interactioni

Subunit structurei

Homotetramer.

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399402EBI-4061,EBI-16219

Protein-protein interaction databases

BioGridi32306, 54 interactors
DIPiDIP-4320N
IntActiP15202, 8 interactors
MINTiP15202
STRINGi4932.YDR256C

Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 34Combined sources4
Beta strandi36 – 39Combined sources4
Turni40 – 42Combined sources3
Helixi50 – 59Combined sources10
Beta strandi72 – 82Combined sources11
Turni87 – 89Combined sources3
Helixi93 – 95Combined sources3
Beta strandi101 – 109Combined sources9
Beta strandi111 – 113Combined sources3
Beta strandi119 – 123Combined sources5
Beta strandi126 – 133Combined sources8
Beta strandi136 – 147Combined sources12
Helixi155 – 163Combined sources9
Turni167 – 169Combined sources3
Helixi174 – 181Combined sources8
Helixi184 – 189Combined sources6
Helixi190 – 197Combined sources8
Helixi199 – 201Combined sources3
Beta strandi202 – 204Combined sources3
Helixi206 – 208Combined sources3
Beta strandi217 – 220Combined sources4
Beta strandi226 – 237Combined sources12
Helixi244 – 253Combined sources10
Helixi257 – 267Combined sources11
Beta strandi273 – 281Combined sources9
Helixi283 – 287Combined sources5
Beta strandi289 – 291Combined sources3
Turni302 – 304Combined sources3
Beta strandi308 – 317Combined sources10
Helixi322 – 325Combined sources4
Turni326 – 328Combined sources3
Beta strandi340 – 342Combined sources3
Helixi346 – 362Combined sources17
Helixi367 – 369Combined sources3
Helixi371 – 373Combined sources3
Turni395 – 398Combined sources4
Beta strandi425 – 427Combined sources3
Beta strandi429 – 432Combined sources4
Beta strandi438 – 440Combined sources3
Helixi441 – 454Combined sources14
Helixi459 – 471Combined sources13
Helixi476 – 487Combined sources12
Helixi491 – 501Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4EX-ray2.40A/B/C/D15-502[»]
ProteinModelPortaliP15202
SMRiP15202
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15202

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi513 – 515Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000018100
HOGENOMiHOG000087852
InParanoidiP15202
KOiK03781
OMAiHADFGRM
OrthoDBiEOG092C0NOX

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLGQEKNE VNYSDVREDR VVTNSTGNPI NEPFVTQRIG EHGPLLLQDY
60 70 80 90 100
NLIDSLAHFN RENIPQRNPH AHGSGAFGYF EVTDDITDIC GSAMFSKIGK
110 120 130 140 150
RTKCLTRFST VGGDKGSADT VRDPRGFATK FYTEEGNLDW VYNNTPVFFI
160 170 180 190 200
RDPSKFPHFI HTQKRNPQTN LRDADMFWDF LTTPENQVAI HQVMILFSDR
210 220 230 240 250
GTPANYRSMH GYSGHTYKWS NKNGDWHYVQ VHIKTDQGIK NLTIEEATKI
260 270 280 290 300
AGSNPDYCQQ DLFEAIQNGN YPSWTVYIQT MTERDAKKLP FSVFDLTKVW
310 320 330 340 350
PQGQFPLRRV GKIVLNENPL NFFAQVEQAA FAPSTTVPYQ EASADPVLQA
360 370 380 390 400
RLFSYADAHR YRLGPNFHQI PVNCPYASKF FNPAIRDGPM NVNGNFGSEP
410 420 430 440 450
TYLANDKSYT YIQQDRPIQQ HQEVWNGPAI PYHWATSPGD VDFVQARNLY
460 470 480 490 500
RVLGKQPGQQ KNLAYNIGIH VEGACPQIQQ RVYDMFARVD KGLSEAIKKV
510
AEAKHASELS SNSKF
Length:515
Mass (Da):58,555
Last modified:April 1, 1990 - v1
Checksum:i22DFCC599D79801F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131F → L in AAU09703 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13028 Genomic DNA Translation: CAA31443.1
Z68329 Genomic DNA Translation: CAA92713.1
Z70202 Genomic DNA Translation: CAA94095.1
AY723786 Genomic DNA Translation: AAU09703.1
BK006938 Genomic DNA Translation: DAA12096.1
PIRiS07868 CSBYP
RefSeqiNP_010542.1, NM_001180564.1

Genome annotation databases

EnsemblFungiiYDR256C; YDR256C; YDR256C
GeneIDi851843
KEGGisce:YDR256C

Similar proteinsi

Entry informationi

Entry nameiCATA_YEAST
AccessioniPrimary (citable) accession number: P15202
Secondary accession number(s): D6VSN6, E9P947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health