P15200 (MATRX_RABVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Matrix protein

Alternative name(s):
Phosphoprotein M2

Gene names

Name:

M

Organism

Rabies virus (strain PM1503/AVO1) (RABV) [Complete proteome]

Taxonomic identifier

11293 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Mononegavirales › Rhabdoviridae › Lyssavirus › Rabies virus

Virus host

Homo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons By similarity.
Subunit structure	Homomultimer. Interacts with nucleoprotein and with the cytoplasmic domain of glycoprotein By similarity.
Subcellular location	Virion membrane; Peripheral membrane protein. Host endomembrane system; Peripheral membrane protein By similarity.
Domain	Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Matrix protein contains one L domain: a PPXY motif which potentially interacts with the WW domain 3 of NEDD4 E3 ubiquitin ligase Potential.
Miscellaneous	Most abundant protein in the virion By similarity.
Sequence similarities	Belongs to the lyssavirus matrix protein family.

Ontologies

Keywords
Biological process	Apoptosis Host-virus interaction Viral budding Viral budding via the host ESCRT complexes Virus exit from host cell
Cellular component	Host membrane Membrane Viral envelope protein Viral matrix protein Virion
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW viral release from host cell Inferred from electronic annotation. Source: UniProtKB-KW virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell viral envelope Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Matrix protein		PRO_0000222846
Regions
	Region	115 – 151	37	Essential for glycoprotein binding By similarity
	Motif	35 – 38	4	PPXY motif Potential
Natural variations
	Natural variant	27	1	D → Y in strain: Isolate AVO1.
	Natural variant	58	1	D → E in strain: Isolate AVO1.
	Natural variant	158	1	S → G in strain: Isolate AVO1.
	Natural variant	173	1	T → S in strain: Isolate AVO1.

Sequences

	Sequence		Length	Mass (Da)
	P15200 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: DA0A18C392BD00AE	FASTA	202	23,213
	10 20 30 40 50 60 MNVLRKIVKK CRDEDTQKPS PVSAPPDDDD LWLPPPEYVP LKELTSKKNM RNFCVNGDVK 70 80 90 100 110 120 ACSPNGYSFR ILRHILRSFN EIYSGNHRMI GLVKVVVGLA LSGAPVPEGM NWVYKLRRTL 130 140 150 160 170 180 IFQWADSRGP LEGEELEYSQ EITWDDDTEF VGLQIRVSAR QCHIQGRIWC INTNSRACQL 190 200 WSDMSLQTQR SEEDKDSSLL LE

References

[1]	"Sequence of the 3386 3' nucleotides of the genome of the AVO1 strain rabies virus: structural similarities in the protein regions involved in transcription." Poch O., Tordo N., Keith G. Biochimie 70:1019-1029(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate AVO1.
[2]	"Characterization of rabies virus vaccine strains." Stallkamp I., Lopez-Yomayuza C.C., Thiel H.-J. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. Strain: Isolate PM1503.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13357 Genomic RNA. Translation: CAA31736.1. DQ099525 Genomic RNA. Translation: AAZ07893.1.
PIR	MFVNAV. S07816.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR006870. Rhabdo_M2. [Graphical view]
Pfam	PF04785. Rhabdo_M2. 1 hit. [Graphical view]
ProDom	PD009661. Rhabdo_M2. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

MATRX_RABVA

Accession

Primary (citable) accession number: P15200
Secondary accession number(s): Q4F901

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	July 24, 2007
Last modified:	April 3, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program