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Protein

Orotidine 5'-phosphate decarboxylase

Gene

PYR6

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Orotidine 5'-phosphate decarboxylase (PYR6)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Active sitei95Proton donorPROSITE-ProRule annotation1
Binding sitei220SubstrateBy similarity1
Binding sitei239SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:PYR6
ORF Names:UMAG_04214
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 12, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_04214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346891 – 283Orotidine 5'-phosphate decarboxylaseAdd BLAST283

Structurei

3D structure databases

ProteinModelPortaliP15188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 64Substrate bindingBy similarity3
Regioni93 – 102Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

HOGENOMiHOG000213905.
InParanoidiP15188.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG092C3SZ1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSITLQSYA SRAAKQPNPA AKALLECMER KQTNLCVSID VTNKQDLLDV
60 70 80 90 100
CEAVGRNVCL VKTHIDIVED FDMDLVHQLT QLSEKHDFLI FEDRKFADIG
110 120 130 140 150
NTVSLQYSAG VHKIASWSHI TNAHLVPGPS VISGLAKVGQ PLGRGLLLLA
160 170 180 190 200
EMSSEGALTK GDYTQACVDE AHKDTTGFVC GFIAMSRVDE RERANTHRDL
210 220 230 240 250
LILTPGVGLD VKGDGLGQQY RTPDQVIRES GCDVIIVGRG IYGALTTEEG
260 270 280
KADKKAAFAK VSEQGERYKT AGWDAYLKRI GQK
Length:283
Mass (Da):30,864
Last modified:December 12, 2006 - v2
Checksum:i7C2F0DBB3C7DDF47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244A → T (PubMed:2673937).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27247 Unassigned DNA. No translation available.
CM003151 Genomic DNA. Translation: KIS67714.1.
PIRiJQ0013. DCUSOP.
RefSeqiXP_011390696.1. XM_011392394.1.

Genome annotation databases

EnsemblFungiiKIS67714; KIS67714; UMAG_04214.
GeneIDi23564467.
KEGGiuma:UMAG_04214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27247 Unassigned DNA. No translation available.
CM003151 Genomic DNA. Translation: KIS67714.1.
PIRiJQ0013. DCUSOP.
RefSeqiXP_011390696.1. XM_011392394.1.

3D structure databases

ProteinModelPortaliP15188.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiKIS67714; KIS67714; UMAG_04214.
GeneIDi23564467.
KEGGiuma:UMAG_04214.

Organism-specific databases

EuPathDBiFungiDB:UMAG_04214.

Phylogenomic databases

HOGENOMiHOG000213905.
InParanoidiP15188.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG092C3SZ1.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYRF_USTMA
AccessioniPrimary (citable) accession number: P15188
Secondary accession number(s): A0A0D1DTT3, Q4P6P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 12, 2006
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.