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P15188

- PYRF_USTMA

UniProt

P15188 - PYRF_USTMA

Protein

Orotidine 5'-phosphate decarboxylase

Gene

PYR6

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateBy similarity
    Active sitei95 – 951Proton donorPROSITE-ProRule annotation
    Binding sitei220 – 2201SubstrateBy similarity
    Binding sitei239 – 2391SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:PYR6
    ORF Names:UM04214
    OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
    Taxonomic identifieri237631 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
    ProteomesiUP000000561: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: EnsemblFungi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Orotidine 5'-phosphate decarboxylasePRO_0000134689Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5270.UM04214.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP15188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 643Substrate bindingBy similarity
    Regioni93 – 10210Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000213905.
    KOiK01591.
    OMAiMGQQYRT.
    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15188-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSITLQSYA SRAAKQPNPA AKALLECMER KQTNLCVSID VTNKQDLLDV    50
    CEAVGRNVCL VKTHIDIVED FDMDLVHQLT QLSEKHDFLI FEDRKFADIG 100
    NTVSLQYSAG VHKIASWSHI TNAHLVPGPS VISGLAKVGQ PLGRGLLLLA 150
    EMSSEGALTK GDYTQACVDE AHKDTTGFVC GFIAMSRVDE RERANTHRDL 200
    LILTPGVGLD VKGDGLGQQY RTPDQVIRES GCDVIIVGRG IYGALTTEEG 250
    KADKKAAFAK VSEQGERYKT AGWDAYLKRI GQK 283
    Length:283
    Mass (Da):30,864
    Last modified:December 12, 2006 - v2
    Checksum:i7C2F0DBB3C7DDF47
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2441A → T(PubMed:2673937)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27247 Unassigned DNA. No translation available.
    AACP01000149 Genomic DNA. Translation: EAK85218.1.
    PIRiJQ0013. DCUSOP.
    RefSeqiXP_760361.1. XM_755268.1.

    Genome annotation databases

    EnsemblFungiiUM04214T0; UM04214P0; UM04214.
    GeneIDi3632319.
    KEGGiuma:UM04214.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27247 Unassigned DNA. No translation available.
    AACP01000149 Genomic DNA. Translation: EAK85218.1 .
    PIRi JQ0013. DCUSOP.
    RefSeqi XP_760361.1. XM_755268.1.

    3D structure databases

    ProteinModelPortali P15188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5270.UM04214.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii UM04214T0 ; UM04214P0 ; UM04214 .
    GeneIDi 3632319.
    KEGGi uma:UM04214.1.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000213905.
    KOi K01591.
    OMAi MGQQYRT.
    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of metabolic genes and demonstration of gene disruption in the phytopathogenic fungus Ustilago maydis."
      Kronstad J.W., Wang J., Covert S.F., Holden D.W., McKnight G.L., Leong S.A.
      Gene 79:97-106(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
      Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
      , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
      Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 521 / FGSC 9021.

    Entry informationi

    Entry nameiPYRF_USTMA
    AccessioniPrimary (citable) accession number: P15188
    Secondary accession number(s): Q4P6P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3