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P15187 (RDRP_CNV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

EC=2.7.7.48
Alternative name(s):
Protein p92

Cleaved into the following chain:

  1. Protein p33
Gene names
ORF Names:ORF1
OrganismCucumber necrosis virus (CNV) [Complete proteome]
Taxonomic identifier12143 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostCucumis sativus (Cucumber) [TaxID: 3659]

Protein attributes

Sequence length818 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase that plays an essential role in the virus replication Probable.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Miscellaneous

Readthrough of the terminator UAG occurs at position 297.

Sequence similarities

Belongs to the tombusviridae RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence caution

The sequence AAA42902.1 differs from that shown. Reason: Amino acid integrated instead of terminator codon missing.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 818818RNA-directed RNA polymerase
PRO_0000041332
Chain1 – 296296Protein p33
PRO_0000041333

Regions

Domain524 – 641118RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P15187 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: 0CE624521246706A

FASTA81892,120
        10         20         30         40         50         60 
MDTIKRMLWP KKEIFVGTFA TGVERDTSVD IFQLVCRVVL RYMRTGKIEN NTDSLGNFIV 

        70         80         90        100        110        120 
ELLKTDCAAK WEWFMKRRRV GDYAKSLAIA SIPVIPLLSY ATMKKTVALR AFGNELSFNI 

       130        140        150        160        170        180 
RVPRPSVPKK GLLLRLAAGL ALAPICALAM YATLPREKLS VFKLRTEARA HMEDEREATD 

       190        200        210        220        230        240 
CLVVEPAREL KGKDGEDLLT GSRMTKVIAS TGRPRRRPYA AKIAQVARAK VGYLKNTPEN 

       250        260        270        280        290        300 
RLIYQRVMIE IMDKDCVRYV DRDVILPLAI GCCFVYPDGV EESAALWGSD ESLGVKXGGL 

       310        320        330        340        350        360 
VRLPGVVTQT NRDIPSGVLL PQEVLEVRAG PPNAKDRNIF MVAGCPSQAR FLVHNHCLKN 

       370        380        390        400        410        420 
LKRGLVERVF CVERNGQLTR TPQPTKGAFG RLSPFRKAVC EKVGVAHRLG YDGFLSYYSG 

       430        440        450        460        470        480 
AKLRTYTRAV ESLHITPVSE RDSHLTTFVK AEKISTAKGD PAPRVIQPRN PRYNVELGRY 

       490        500        510        520        530        540 
LRHMESKLMK AVDGVFGETT CIKGYTADEV GQIFRDKWDR FNKPVAIGLD ASRFDQHCSV 

       550        560        570        580        590        600 
EALQFEHGFY RAMYPGNKLL SKLLDWQLHN KGKGYVPDGT ITYRKEGCRM SGDINTSLGN 

       610        620        630        640        650        660 
YLLMCAMIYG YMRHLGINEY SLANCGDDCV LIVERRNLKQ IQGTLPEYFL NLGYTMKVEP 

       670        680        690        700        710        720 
PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN NIRDLATRRA WSNAQHHGGV 

       730        740        750        760        770        780 
ALTSGIPVVE KFYSRFTLYE VPKKHQRIDT VTNVHKWRGS GGDYVVTPEA RASFWAAFGL 

       790        800        810 
TGDEQLALED RLDRWEMDLF GEEGVDAHEP SILDSAVA 

« Hide

References

[1]"Complete nucleotide sequence of the cucumber necrosis virus genome."
Rochon D.M., Tremaine J.H.
Virology 169:251-259(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25270 Genomic RNA. Translation: AAA42902.1. Sequence problems.
PIRRRVGCN. JA0130.
RefSeqNP_040953.2. NC_001469.1.

3D structure databases

ProteinModelPortalP15187.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1493946.

Family and domain databases

InterProIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_CNV
AccessionPrimary (citable) accession number: P15187
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families