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P15187

- RDRP_CNV

UniProt

P15187 - RDRP_CNV

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Protein

RNA-directed RNA polymerase

Gene
ORF1
Organism
Cucumber necrosis virus (CNV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication Inferred.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p92
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiCucumber necrosis virus (CNV)
Taxonomic identifieri12143 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCucumis sativus (Cucumber) [TaxID: 3659]
ProteomesiUP000008565: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818RNA-directed RNA polymerasePRO_0000041332Add
BLAST
Chaini1 – 296296Protein p33PRO_0000041333Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP15187.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini524 – 641118RdRp catalyticAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15187-1 [UniParc]FASTAAdd to Basket

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MDTIKRMLWP KKEIFVGTFA TGVERDTSVD IFQLVCRVVL RYMRTGKIEN    50
NTDSLGNFIV ELLKTDCAAK WEWFMKRRRV GDYAKSLAIA SIPVIPLLSY 100
ATMKKTVALR AFGNELSFNI RVPRPSVPKK GLLLRLAAGL ALAPICALAM 150
YATLPREKLS VFKLRTEARA HMEDEREATD CLVVEPAREL KGKDGEDLLT 200
GSRMTKVIAS TGRPRRRPYA AKIAQVARAK VGYLKNTPEN RLIYQRVMIE 250
IMDKDCVRYV DRDVILPLAI GCCFVYPDGV EESAALWGSD ESLGVKXGGL 300
VRLPGVVTQT NRDIPSGVLL PQEVLEVRAG PPNAKDRNIF MVAGCPSQAR 350
FLVHNHCLKN LKRGLVERVF CVERNGQLTR TPQPTKGAFG RLSPFRKAVC 400
EKVGVAHRLG YDGFLSYYSG AKLRTYTRAV ESLHITPVSE RDSHLTTFVK 450
AEKISTAKGD PAPRVIQPRN PRYNVELGRY LRHMESKLMK AVDGVFGETT 500
CIKGYTADEV GQIFRDKWDR FNKPVAIGLD ASRFDQHCSV EALQFEHGFY 550
RAMYPGNKLL SKLLDWQLHN KGKGYVPDGT ITYRKEGCRM SGDINTSLGN 600
YLLMCAMIYG YMRHLGINEY SLANCGDDCV LIVERRNLKQ IQGTLPEYFL 650
NLGYTMKVEP PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN 700
NIRDLATRRA WSNAQHHGGV ALTSGIPVVE KFYSRFTLYE VPKKHQRIDT 750
VTNVHKWRGS GGDYVVTPEA RASFWAAFGL TGDEQLALED RLDRWEMDLF 800
GEEGVDAHEP SILDSAVA 818
Length:818
Mass (Da):92,120
Last modified:October 5, 2010 - v2
Checksum:i0CE624521246706A
GO

Sequence cautioni

The sequence AAA42902.1 differs from that shown. Reason: Amino acid integrated instead of terminator codon missing.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25270 Genomic RNA. Translation: AAA42902.1. Sequence problems.
PIRiJA0130. RRVGCN.
RefSeqiNP_040953.2. NC_001469.1.

Genome annotation databases

GeneIDi1493946.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25270 Genomic RNA. Translation: AAA42902.1 . Sequence problems.
PIRi JA0130. RRVGCN.
RefSeqi NP_040953.2. NC_001469.1.

3D structure databases

ProteinModelPortali P15187.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1493946.

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
IPR013707. Tombusvirus_p33.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
PF08500. Tombus_P33. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete nucleotide sequence of the cucumber necrosis virus genome."
    Rochon D.M., Tremaine J.H.
    Virology 169:251-259(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_CNV
AccessioniPrimary (citable) accession number: P15187
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 297.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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