Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P15187

- RDRP_CNV

UniProt

P15187 - RDRP_CNV

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Cucumber necrosis virus (CNV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p92
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiCucumber necrosis virus (CNV)
    Taxonomic identifieri12143 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
    Virus hostiCucumis sativus (Cucumber) [TaxID: 3659]
    ProteomesiUP000008565: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 818818RNA-directed RNA polymerasePRO_0000041332Add
    BLAST
    Chaini1 – 296296Protein p33PRO_0000041333Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP15187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini524 – 641118RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15187-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTIKRMLWP KKEIFVGTFA TGVERDTSVD IFQLVCRVVL RYMRTGKIEN    50
    NTDSLGNFIV ELLKTDCAAK WEWFMKRRRV GDYAKSLAIA SIPVIPLLSY 100
    ATMKKTVALR AFGNELSFNI RVPRPSVPKK GLLLRLAAGL ALAPICALAM 150
    YATLPREKLS VFKLRTEARA HMEDEREATD CLVVEPAREL KGKDGEDLLT 200
    GSRMTKVIAS TGRPRRRPYA AKIAQVARAK VGYLKNTPEN RLIYQRVMIE 250
    IMDKDCVRYV DRDVILPLAI GCCFVYPDGV EESAALWGSD ESLGVKXGGL 300
    VRLPGVVTQT NRDIPSGVLL PQEVLEVRAG PPNAKDRNIF MVAGCPSQAR 350
    FLVHNHCLKN LKRGLVERVF CVERNGQLTR TPQPTKGAFG RLSPFRKAVC 400
    EKVGVAHRLG YDGFLSYYSG AKLRTYTRAV ESLHITPVSE RDSHLTTFVK 450
    AEKISTAKGD PAPRVIQPRN PRYNVELGRY LRHMESKLMK AVDGVFGETT 500
    CIKGYTADEV GQIFRDKWDR FNKPVAIGLD ASRFDQHCSV EALQFEHGFY 550
    RAMYPGNKLL SKLLDWQLHN KGKGYVPDGT ITYRKEGCRM SGDINTSLGN 600
    YLLMCAMIYG YMRHLGINEY SLANCGDDCV LIVERRNLKQ IQGTLPEYFL 650
    NLGYTMKVEP PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN 700
    NIRDLATRRA WSNAQHHGGV ALTSGIPVVE KFYSRFTLYE VPKKHQRIDT 750
    VTNVHKWRGS GGDYVVTPEA RASFWAAFGL TGDEQLALED RLDRWEMDLF 800
    GEEGVDAHEP SILDSAVA 818
    Length:818
    Mass (Da):92,120
    Last modified:October 5, 2010 - v2
    Checksum:i0CE624521246706A
    GO

    Sequence cautioni

    The sequence AAA42902.1 differs from that shown. Reason: Amino acid integrated instead of terminator codon missing.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25270 Genomic RNA. Translation: AAA42902.1. Sequence problems.
    PIRiJA0130. RRVGCN.
    RefSeqiNP_040953.2. NC_001469.1.

    Genome annotation databases

    GeneIDi1493946.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25270 Genomic RNA. Translation: AAA42902.1 . Sequence problems.
    PIRi JA0130. RRVGCN.
    RefSeqi NP_040953.2. NC_001469.1.

    3D structure databases

    ProteinModelPortali P15187.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1493946.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of the cucumber necrosis virus genome."
      Rochon D.M., Tremaine J.H.
      Virology 169:251-259(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_CNV
    AccessioniPrimary (citable) accession number: P15187
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 297.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3