ID   P19_CNV                 Reviewed;         173 AA.
AC   P15184;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=RNA silencing suppressor p19;
DE   AltName: Full=19 kDa symptom severity modulator;
GN   ORFNames=ORF4;
OS   Cucumber necrosis virus (CNV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC   Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus;
OC   Tombusvirus cucumis.
OX   NCBI_TaxID=12143;
OH   NCBI_TaxID=3659; Cucumis sativus (Cucumber).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2705296; DOI=10.1016/0042-6822(89)90150-5;
RA   Rochon D.M., Tremaine J.H.;
RT   "Complete nucleotide sequence of the cucumber necrosis virus genome.";
RL   Virology 169:251-259(1989).
CC   -!- FUNCTION: Viral suppressor of RNA silencing which binds specifically to
CC       silencing RNAs (siRNAs). Acts as a molecular caliper to specifically
CC       select siRNAs based on the length of the duplex region of the RNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tombusvirus protein p19 family.
CC       {ECO:0000305}.
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DR   EMBL; M25270; AAA42906.1; -; Genomic_RNA.
DR   PIR; JA0133; NKVGCU.
DR   RefSeq; NP_040957.1; NC_001469.1.
DR   SMR; P15184; -.
DR   GeneID; 1493948; -.
DR   KEGG; vg:1493948; -.
DR   OrthoDB; 10877at10239; -.
DR   Proteomes; UP000008565; Genome.
DR   GO; GO:0044423; C:virion component; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.180; RNA silencing suppressor P19; 1.
DR   InterPro; IPR004905; Tombusvirus_p19.
DR   InterPro; IPR036131; VP19_sf.
DR   Pfam; PF03220; Tombus_P19; 1.
DR   SUPFAM; SSF103145; Tombusvirus P19 core protein, VP19; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   RNA-binding; Suppressor of RNA silencing; Viral immunoevasion.
FT   CHAIN           1..173
FT                   /note="RNA silencing suppressor p19"
FT                   /id="PRO_0000222873"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  19808 MW;  D05F870D4AA4C80F CRC64;
     MERAIQRSDA REQANSERWD GRCGGTITPF KLPDESPSLL EWRLHNSEES EDKDHPLGFK
     ESWSFGKVVF KRYLRYDGTE TSLHRTLGSW ERNSVNDAAS RFLGVSQIGC TYSIRFRGSC
     LTLSGGSRTL QRLIEMAIRT KRTMLQLTPC EVEGNVSRRR PQGSEAFENK ESE
//