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P15184 (P19_CNV) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene names
ORF Names:ORF4
OrganismCucumber necrosis virus (CNV) [Complete proteome]
Taxonomic identifier12143 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostCucumis sativus (Cucumber) [TaxID: 3659]

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the tombusvirus protein p19 family.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionSuppressor of RNA silencing
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvirion

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173RNA silencing suppressor p19
PRO_0000222873

Sequences

Sequence LengthMass (Da)Tools
P15184 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: D05F870D4AA4C80F

FASTA17319,808
        10         20         30         40         50         60 
MERAIQRSDA REQANSERWD GRCGGTITPF KLPDESPSLL EWRLHNSEES EDKDHPLGFK 

        70         80         90        100        110        120 
ESWSFGKVVF KRYLRYDGTE TSLHRTLGSW ERNSVNDAAS RFLGVSQIGC TYSIRFRGSC 

       130        140        150        160        170 
LTLSGGSRTL QRLIEMAIRT KRTMLQLTPC EVEGNVSRRR PQGSEAFENK ESE 

« Hide

References

[1]"Complete nucleotide sequence of the cucumber necrosis virus genome."
Rochon D.M., Tremaine J.H.
Virology 169:251-259(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25270 Genomic RNA. Translation: AAA42906.1.
PIRNKVGCU. JA0133.
RefSeqNP_040957.1. NC_001469.1.

3D structure databases

ProteinModelPortalP15184.
SMRP15184. Positions 9-152.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1493948.

Family and domain databases

InterProIPR004905. Tombusvirus_p19.
[Graphical view]
PfamPF03220. Tombus_P19. 1 hit.
[Graphical view]
ProDomPD005743. Tombus_P19. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF103145. SSF103145. 1 hit.
ProtoNetSearch...

Entry information

Entry nameP19_CNV
AccessionPrimary (citable) accession number: P15184
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families