ID   MYOG_HUMAN              Reviewed;         224 AA.
AC   P15173; Q53XW6;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 2.
DT   25-JAN-2012, entry version 110.
DE   RecName: Full=Myogenin;
DE   AltName: Full=Class C basic helix-loop-helix protein 3;
DE            Short=bHLHc3;
DE   AltName: Full=Myogenic factor 4;
DE            Short=Myf-4;
GN   Name=MYOG; Synonyms=BHLHC3, MYF4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RX   MEDLINE=90059960; PubMed=2583111;
RA   Braun T., Bober E., Buschhausen-Denker G., Kohtz S., Grzeschik K.-H.,
RA   Arnold H.H.;
RT   "Differential expression of myogenic determination genes in muscle
RT   cells: possible autoactivation by the Myf gene products.";
RL   EMBO J. 8:3617-3625(1989).
RN   [2]
RP   ERRATUM, AND SEQUENCE REVISION.
RA   Braun T., Bober E., Buschhausen-Denker G., Kohtz S., Grzeschik K.-H.,
RA   Arnold H.H.;
RL   EMBO J. 9:592-592(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=92064650; PubMed=1659574; DOI=10.1083/jcb.115.4.905;
RA   Salminen A., Braun T., Buchberger A., Juers S., Winter B.,
RA   Arnold H.H.;
RT   "Transcription of the muscle regulatory gene Myf4 is regulated by
RT   serum components, peptide growth factors and signaling pathways
RT   involving G proteins.";
RL   J. Cell Biol. 115:905-917(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in muscle differentiation (myogenic factor).
CC       Induces fibroblasts to differentiate into myoblasts. Probable
CC       sequence specific DNA-binding protein.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another
CC       bHLH protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
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DR   EMBL; X17651; CAA35641.1; ALT_SEQ; mRNA.
DR   EMBL; X62155; CAA44080.1; -; Genomic_DNA.
DR   EMBL; BT007233; AAP35897.1; -; mRNA.
DR   EMBL; CH471067; EAW91463.1; -; Genomic_DNA.
DR   EMBL; BC053899; AAH53899.1; -; mRNA.
DR   IPI; IPI00010313; -.
DR   PIR; A41128; A41128.
DR   RefSeq; NP_002470.2; NM_002479.4.
DR   UniGene; Hs.2830; -.
DR   ProteinModelPortal; P15173; -.
DR   SMR; P15173; 74-136.
DR   DIP; DIP-159N; -.
DR   IntAct; P15173; 4.
DR   STRING; P15173; -.
DR   PhosphoSite; P15173; -.
DR   DMDM; 127625; -.
DR   PRIDE; P15173; -.
DR   Ensembl; ENST00000241651; ENSP00000241651; ENSG00000122180.
DR   GeneID; 4656; -.
DR   KEGG; hsa:4656; -.
DR   UCSC; uc001gzd.1; human.
DR   CTD; 4656; -.
DR   GeneCards; GC01M203052; -.
DR   H-InvDB; HIX0023649; -.
DR   HGNC; HGNC:7612; MYOG.
DR   HPA; HPA038093; -.
DR   MIM; 159980; gene.
DR   neXtProt; NX_P15173; -.
DR   PharmGKB; PA31417; -.
DR   eggNOG; prNOG12115; -.
DR   HOGENOM; HBG714454; -.
DR   HOVERGEN; HBG006429; -.
DR   InParanoid; P15173; -.
DR   OMA; PNPGDHL; -.
DR   OrthoDB; EOG4RR6JP; -.
DR   PhylomeDB; P15173; -.
DR   Reactome; REACT_111045; Developmental Biology.
DR   NextBio; 17946; -.
DR   ArrayExpress; P15173; -.
DR   Bgee; P15173; -.
DR   CleanEx; HS_MYOG; -.
DR   Genevestigator; P15173; -.
DR   GermOnline; ENSG00000122180; Homo sapiens.
DR   GO; GO:0005667; C:transcription factor complex; ISS:BHF-UCL.
DR   GO; GO:0070888; F:E-box binding; ISS:BHF-UCL.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:BHF-UCL.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
DR   GO; GO:0042693; P:muscle cell fate commitment; ISS:BHF-UCL.
DR   GO; GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
DR   InterPro; IPR002546; Basic.
DR   InterPro; IPR011598; HLH_DNA-bd.
DR   Gene3D; G3DSA:4.10.280.10; HLH_DNA_bd; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH_basic; 1.
DR   PROSITE; PS50888; HLH; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   DNA-binding; Myogenesis; Nucleus; Reference proteome.
FT   CHAIN         1    224       Myogenin.
FT                                /FTId=PRO_0000127375.
FT   DOMAIN       94    133       Helix-loop-helix motif.
FT   DNA_BIND     81     93       Basic motif.
SQ   SEQUENCE   224 AA;  25037 MW;  91421D69B57551FB CRC64;
     MELYETSPYF YQEPRFYDGE NYLPVHLQGF EPPGYERTEL TLSPEAPGPL EDKGLGTPEH
     CPGQCLPWAC KVCKRKSVSV DRRRAATLRE KRRLKKVNEA FEALKRSTLL NPNQRLPKVE
     ILRSAIQYIE RLQALLSSLN QEERDLRYRG GGGPQPGVPS ECSSHSASCS PEWGSALEFS
     ANPGDHLLTA DPTDAHNLHS LTSIVDSITV EDVSVAFPDE TMPN
//