P15173 (MYOG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myogenin

Alternative name(s):
Class C basic helix-loop-helix protein 3
Short name=bHLHc3
Myogenic factor 4
Short name=Myf-4

Gene names

Name:	MYOG
Synonyms:	BHLHC3, MYF4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular location	Nucleus.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Differentiation Myogenesis
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	muscle cell fate commitment Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of muscle cell differentiation Traceable author statement. Source: Reactome positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular component	transcription factor complex Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular function	E-box binding Inferred from sequence or structural similarity. Source: BHF-UCL protein heterodimerization activity Inferred from sequence or structural similarity. Source: BHF-UCL sequence-specific DNA binding transcription factor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Myogenin		PRO_0000127375
Regions
	Domain	94 – 133	40	Helix-loop-helix motif
	DNA binding	81 – 93	13	Basic motif

Sequences

	Sequence		Length	Mass (Da)
	P15173 [UniParc]. Last modified December 1, 1992. Version 2. Checksum: 91421D69B57551FB	FASTA	224	25,037
	10 20 30 40 50 60 MELYETSPYF YQEPRFYDGE NYLPVHLQGF EPPGYERTEL TLSPEAPGPL EDKGLGTPEH 70 80 90 100 110 120 CPGQCLPWAC KVCKRKSVSV DRRRAATLRE KRRLKKVNEA FEALKRSTLL NPNQRLPKVE 130 140 150 160 170 180 ILRSAIQYIE RLQALLSSLN QEERDLRYRG GGGPQPGVPS ECSSHSASCS PEWGSALEFS 190 200 210 220 ANPGDHLLTA DPTDAHNLHS LTSIVDSITV EDVSVAFPDE TMPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products." Braun T., Bober E., Buschhausen-Denker G., Kohtz S., Grzeschik K.-H., Arnold H.H. EMBO J. 8:3617-3625(1989) [PubMed: 2583111] [Abstract] Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[2]	Erratum Braun T., Bober E., Buschhausen-Denker G., Kohtz S., Grzeschik K.-H., Arnold H.H. EMBO J. 9:592-592(1990) Cited for: SEQUENCE REVISION.
[3]	"Transcription of the muscle regulatory gene Myf4 is regulated by serum components, peptide growth factors and signaling pathways involving G proteins." Salminen A., Braun T., Buchberger A., Juers S., Winter B., Arnold H.H. J. Cell Biol. 115:905-917(1991) [PubMed: 1659574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17651 mRNA. Translation: CAA35641.1. Sequence problems. X62155 Genomic DNA. Translation: CAA44080.1. BT007233 mRNA. Translation: AAP35897.1. CH471067 Genomic DNA. Translation: EAW91463.1. BC053899 mRNA. Translation: AAH53899.1.
IPI	IPI00010313.
PIR	A41128.
RefSeq	NP_002470.2. NM_002479.4.
UniGene	Hs.2830.
3D structure databases
ProteinModelPortal	P15173.
SMR	P15173. Positions 74-136.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-159N.
IntAct	P15173. 4 interactions.
STRING	P15173.
PTM databases
PhosphoSite	P15173.
Polymorphism databases
DMDM	127625.
Proteomic databases
PRIDE	P15173.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000241651; ENSP00000241651; ENSG00000122180.
GeneID	4656.
KEGG	hsa:4656.
UCSC	uc001gzd.1. human.
Organism-specific databases
CTD	4656.
GeneCards	GC01M203052.
H-InvDB	HIX0023649.
HGNC	HGNC:7612. MYOG.
HPA	HPA038093.
MIM	159980. gene.
neXtProt	NX_P15173.
PharmGKB	PA31417.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12115.
HOGENOM	HBG714454.
HOVERGEN	HBG006429.
InParanoid	P15173.
OMA	PNPGDHL.
OrthoDB	EOG4RR6JP.
PhylomeDB	P15173.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	P15173.
Bgee	P15173.
CleanEx	HS_MYOG.
Genevestigator	P15173.
GermOnline	ENSG00000122180. Homo sapiens.
Family and domain databases
InterPro	IPR002546. Basic. IPR011598. HLH_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF01586. Basic. 1 hit. PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00520. BASIC. 1 hit. SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	17946.
SOURCE	Search...

Entry information

Entry name

MYOG_HUMAN

Accession

Primary (citable) accession number: P15173
Secondary accession number(s): Q53XW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	December 1, 1992
Last modified:	January 25, 2012
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.