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Protein

Myogenin

Gene

MYOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processCell cycle, Differentiation, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-375170 CDO in myogenesis
SignaLinkiP15173
SIGNORiP15173

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenin
Alternative name(s):
Class C basic helix-loop-helix protein 3
Short name:
bHLHc3
Myogenic factor 4
Short name:
Myf-4
Gene namesi
Name:MYOG
Synonyms:BHLHC3, MYF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000122180.4
HGNCiHGNC:7612 MYOG
MIMi159980 gene
neXtProtiNX_P15173

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4656
OpenTargetsiENSG00000122180
PharmGKBiPA31417

Polymorphism and mutation databases

DMDMi127625

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273751 – 224MyogeninAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphoserine; by CaMK2GBy similarity1
Modified residuei79Phosphoserine; by CaMK2GBy similarity1
Modified residuei87Phosphothreonine; by CaMK2GBy similarity1

Post-translational modificationi

Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP15173
PaxDbiP15173
PeptideAtlasiP15173
PRIDEiP15173

PTM databases

iPTMnetiP15173
PhosphoSitePlusiP15173

Expressioni

Gene expression databases

BgeeiENSG00000122180
CleanExiHS_MYOG
GenevisibleiP15173 HS

Organism-specific databases

HPAiHPA028336
HPA038093

Interactioni

Subunit structurei

Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminal region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex (By similarity). Interacts with CSRP3.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110739, 34 interactors
DIPiDIP-159N
IntActiP15173, 46 interactors
MINTiP15173
STRINGi9606.ENSP00000241651

Structurei

3D structure databases

ProteinModelPortaliP15173
SMRiP15173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 132bHLHPROSITE-ProRule annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
HOGENOMiHOG000234799
HOVERGENiHBG006429
InParanoidiP15173
KOiK18483
OMAiPNPGDHL
OrthoDBiEOG091G0GKD
PhylomeDBiP15173
TreeFamiTF316344

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P15173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELYETSPYF YQEPRFYDGE NYLPVHLQGF EPPGYERTEL TLSPEAPGPL
60 70 80 90 100
EDKGLGTPEH CPGQCLPWAC KVCKRKSVSV DRRRAATLRE KRRLKKVNEA
110 120 130 140 150
FEALKRSTLL NPNQRLPKVE ILRSAIQYIE RLQALLSSLN QEERDLRYRG
160 170 180 190 200
GGGPQPGVPS ECSSHSASCS PEWGSALEFS ANPGDHLLTA DPTDAHNLHS
210 220
LTSIVDSITV EDVSVAFPDE TMPN
Length:224
Mass (Da):25,037
Last modified:December 1, 1992 - v2
Checksum:i91421D69B57551FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17651 mRNA Translation: CAA35641.1 Sequence problems.
X62155 Genomic DNA Translation: CAA44080.1
BT007233 mRNA Translation: AAP35897.1
CH471067 Genomic DNA Translation: EAW91463.1
BC053899 mRNA Translation: AAH53899.1
CCDSiCCDS1433.1
PIRiA41128
RefSeqiNP_002470.2, NM_002479.5
UniGeneiHs.2830

Genome annotation databases

EnsembliENST00000241651; ENSP00000241651; ENSG00000122180
GeneIDi4656
KEGGihsa:4656
UCSCiuc001gzd.5 human

Similar proteinsi

Entry informationi

Entry nameiMYOG_HUMAN
AccessioniPrimary (citable) accession number: P15173
Secondary accession number(s): Q53XW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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