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P15146

- MTAP2_RAT

UniProt

P15146 - MTAP2_RAT

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Protein
Microtubule-associated protein 2
Gene
Map2, Mtap2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

GO - Molecular functioni

  1. protein binding Source: RGD
Complete GO annotation...

GO - Biological processi

  1. response to estradiol Source: RGD
  2. response to progesterone Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
Gene namesi
Name:Map2
Synonyms:Mtap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3044. Map2.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. dendrite Source: BHF-UCL
  2. microtubule Source: UniProtKB-KW
  3. neuron projection Source: RGD
  4. neuronal cell body Source: RGD
  5. protein complex Source: RGD
  6. rough endoplasmic reticulum Source: RGD
  7. smooth endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18611861Microtubule-associated protein 2
PRO_0000072749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei728 – 7281Phosphoserine By similarity
Modified residuei1353 – 13531Phosphoserine By similarity
Modified residuei1359 – 13591Phosphothreonine By similarity
Modified residuei1608 – 16081Phosphothreonine By similarity
Modified residuei1611 – 16111Phosphothreonine By similarity
Modified residuei1682 – 16821Phosphoserine; by MARK11 Publication

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 3/MAP2c is probably phosphorylated by PKA at Ser-319, Ser-350 and Ser-382 and by FYN at Tyr-67.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP15146.
PRIDEiP15146.

PTM databases

PhosphoSiteiP15146.

Expressioni

Developmental stagei

Isoform 3/MAP2c is expressed during embryonic brain development and until postanatal day 10. Isoform 2 is expressed throughout brain development.

Gene expression databases

GenevestigatoriP15146.

Interactioni

Protein-protein interaction databases

IntActiP15146. 4 interactions.
MINTiMINT-261227.

Structurei

3D structure databases

DisProtiDP00122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1664 – 169431Tau/MAP 1
Add
BLAST
Repeati1695 – 172531Tau/MAP 2
Add
BLAST
Repeati1726 – 175631Tau/MAP 3
Add
BLAST
Repeati1757 – 178832Tau/MAP 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1454 – 147421Calmodulin-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 4 Tau/MAP repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG148882.
HOGENOMiHOG000113477.
HOVERGENiHBG006322.
InParanoidiP15146.
KOiK10430.
PhylomeDBiP15146.

Family and domain databases

InterProiIPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 1 hit.
PfamiPF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 4 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 3 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P15146-1) [UniParc]FASTAAdd to Basket

Also known as: MAP2x

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY     50
REEEEGAFGE HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA 100
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET VNLPPSPPPS PASEQTAALE 150
EDLLTASKME FPEQQKLPSS FAEPLDKEET EFKMQSKPGE DFEHAALVPQ 200
PDTSKTPQDK KDPQDMEGEK SPASPFAQTF GTNLEDIKQI TEPSITVPSI 250
GLSAEPLAPK DQKDWFIEMP VESKKDEWGL AAPISPGPLT PMREKDVLED 300
IPRWEGKQFD SPMPSPFHGG SFTLPLDTVK DERVTEGSQP FAPVFFQSDD 350
KMSLQDTSGS ATSKESSKDE EPQKDKADKV ADVPVSEATT VLGDVHSPAV 400
EGFVGENISG EEKGTTDQEK KETSTPSVQE PTLTETEPQT KLEETSKVSI 450
EETVAKEEES LKLKDDKAGV IQTSTEQSFS KEDQKGQEQT IEALKQDSFP 500
ISLEQAVTDA AMATKTLEKV TSEPEAVSEK REIQGLFEED IADKSKLEGA 550
GSATVAEVEM PFYEDKSGMS KYFETSALKE DVTRSTGLGS DYYELSDSRG 600
NAQESLDTVS PKNQQDEKEL LAKASQPSPP AHEAGYSTLA QSYTSDHPSE 650
LPEEPSSPQE RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ 700
RSMSINLPMS CLDSIALGFN FGRGHDLSPL ASDILTNTSG SMDEGDDYLP 750
PTTPAVEKIP CFPIESKEEE DKTEQAKVTG GQTTQVETSS ESPFPAKEYY 800
KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS EAVVAESSTG 850
LPPVADDSQP VKPDSQLEDM GYCVFNKYTV PLPSPVQDSE NLSGESGSFY 900
EGTDDKVRRD LATDLSLIEV KLAAAGRVKD EFTAEKEASP PSSADKSGLS 950
REFDQDRKAN DKLDTVLEKS EEHVDSKEHA KESEEVGDKV ELFGLGVTYE 1000
QTSAKELITT KETAPERAEK GLSSVPEVAE VETTTKADQG LDVAAKKDDQ 1050
SPLDIKVSDF GQMASGMSVD AGKTIELKFE VDQQLTLSSE APQETDSFMG 1100
IESSHVKDGA KVSETEVKEK VAKPDLVHQE AVDKEESYES SGEHESLTME 1150
SLKPDEGKKE TSPETSLIQD EVALKLSVEI PCPPPVSEAD SSIDEKAEVQ 1200
MEFIQLPKEE STETPDIPAI PSDVTQPQPE AVVSEPAEVR GEEEEIEAEG 1250
EYDKLLFRSD TLQITDLLVP GSREEFVETC PGEHKGVVES VVTIEDDFIT 1300
VVQTTTDEGE LGSHSVRFAA PVQPEEERRP YPHDEELEVL MAAEAQAEPK 1350
DGSPDAPATP EKEEVPFSEY KTETYDDYKD ETTIDDSIMD ADSLWVDTQD 1400
DDRSILTEQL ETIPKEERAE KEARRPSLEK HRKEKPFKTG RGRISTPERR 1450
EVAKKEPSTV SRDEVRRKKA VYKKAELAKE SEVQAHSPSR KLILKPAIKY 1500
TRPTHLSCVK RKTTATSGES AQAPSAFKQA KDKVTDGITK SPEKRSSLPR 1550
PSSILPPRRG VSGDREENSF SLNSSISSAR RTTRSEPIRR AGKSGTSTPT 1600
TPGSTAITPG TPPSYSSRTP GTPGTPSYPR TPGTPKSGIL VPSEKKVAII 1650
RTPPKSPATP KQLRLINQPL PDLKNVKSKI GSTDNIKYQP KGGQVRILNK 1700
KMDFSKVQSR CGSKDNIKHS AGGGNVQIVT KKIDLSHVTS KCGSLKNIRH 1750
RPGGGRVKIE SVKLDFKEKA QAKVGSLDNA HHVPGGGNVK IDSQKLNFRE 1800
HAKARVDHGA EIITQSPSRS SVASPRRLSN VSSSGSINLL ESPQLATLAE 1850
DVTAALAKQG L 1861
Length:1,861
Mass (Da):202,411
Last modified:June 1, 1994 - v3
Checksum:i42DCF116D21EF54E
GO
Isoform 2 (identifier: P15146-2) [UniParc]FASTAAdd to Basket

Also known as: MAP2b

The sequence of this isoform differs from the canonical sequence as follows:
     1695-1725: Missing.

Show »
Length:1,830
Mass (Da):199,053
Checksum:i2A52B720268B0551
GO
Isoform 3 (identifier: P15146-3) [UniParc]FASTAAdd to Basket

Also known as: MAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.
     1695-1725: Missing.

Note: Contains a phosphoserine at position 319. Contains a phosphoserine at position 350. Contains a phosphoserine at position 382.

Show »
Length:467
Mass (Da):49,300
Checksum:i35ACB5CA6E542606
GO
Isoform 4 (identifier: P15146-4) [UniParc]FASTAAdd to Basket

Also known as: MAP2d

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.

Show »
Length:498
Mass (Da):52,658
Checksum:iD0CE2BD6CE0ABA3E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei152 – 15141363Missing in isoform 3 and isoform 4.
VSP_003198Add
BLAST
Alternative sequencei1695 – 172531Missing in isoform 2 and isoform 3.
VSP_003199Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51842 mRNA. Translation: CAA36135.1.
X17682 mRNA. Translation: CAA35667.1.
X71487 mRNA. Translation: CAA50588.1.
PIRiA37981.
I55502. S33176.
RefSeqiXP_006245164.1. XM_006245102.1. [P15146-3]
UniGeneiRn.10484.
Rn.136301.
Rn.230443.

Genome annotation databases

GeneIDi25595.
KEGGirno:25595.
UCSCiRGD:3044. rat. [P15146-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51842 mRNA. Translation: CAA36135.1 .
X17682 mRNA. Translation: CAA35667.1 .
X71487 mRNA. Translation: CAA50588.1 .
PIRi A37981.
I55502. S33176.
RefSeqi XP_006245164.1. XM_006245102.1. [P15146-3 ]
UniGenei Rn.10484.
Rn.136301.
Rn.230443.

3D structure databases

DisProti DP00122.
ModBasei Search...

Protein-protein interaction databases

IntActi P15146. 4 interactions.
MINTi MINT-261227.

PTM databases

PhosphoSitei P15146.

Proteomic databases

PaxDbi P15146.
PRIDEi P15146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25595.
KEGGi rno:25595.
UCSCi RGD:3044. rat. [P15146-1 ]

Organism-specific databases

CTDi 4133.
RGDi 3044. Map2.

Phylogenomic databases

eggNOGi NOG148882.
HOGENOMi HOG000113477.
HOVERGENi HBG006322.
InParanoidi P15146.
KOi K10430.
PhylomeDBi P15146.

Gene expression databases

Genevestigatori P15146.

Family and domain databases

InterProi IPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view ]
PANTHERi PTHR11501. PTHR11501. 1 hit.
Pfami PF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 4 hits.
[Graphical view ]
PROSITEi PS00229. TAU_MAP_1. 3 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete cDNA sequence encoding rat high and low molecular weight MAP2."
    Kindler S., Schwanke B., Schulz B., Garner C.C.
    Nucleic Acids Res. 18:2822-2822(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: Wistar.
    Tissue: Brain.
  2. "Molecular structure of microtubule-associated protein 2b and 2c from rat brain."
    Kindler S., Schulz B., Goedert M., Garner C.C.
    J. Biol. Chem. 265:19679-19684(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: Wistar.
    Tissue: Brain.
  3. "Nucleotide and amino acid sequences of embryonic rat MAP2c."
    Doll T., Papandrikopoulou A., Matus A.
    Nucleic Acids Res. 18:361-361(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2."
    Papandrikopoulou A., Doll T., Tucker R.P., Garner C.C., Matus A.
    Nature 340:650-652(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  5. "An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin-binding motif."
    Doll T., Meichsner M., Riederer B.M., Honegger P., Matus A.
    J. Cell Sci. 106:633-640(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1695-1725 (ISOFORM 1).
  6. "MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption."
    Drewes G., Ebneth A., Preuss U., Mandelkow E.-M., Mandelkow E.
    Cell 89:297-308(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-1682.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  7. "Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton."
    Ozer R.S., Halpain S.
    Mol. Biol. Cell 11:3573-3587(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-319; SER-350 AND SER-382 (ISOFORM 3).

Entry informationi

Entry nameiMTAP2_RAT
AccessioniPrimary (citable) accession number: P15146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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