Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microtubule-associated protein 2

Gene

Map2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
Gene namesi
Name:Map2
Synonyms:Mtap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3044. Map2.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: BHF-UCL
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: GO_Central
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • protein complex Source: RGD
  • rough endoplasmic reticulum Source: RGD
  • smooth endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000727491 – 1861Microtubule-associated protein 2Add BLAST1861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineBy similarity1
Modified residuei37PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei285PhosphoserineBy similarity1
Modified residuei348PhosphoserineCombined sources1
Modified residuei478PhosphoserineBy similarity1
Modified residuei498PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei552PhosphoserineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei728PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei736PhosphothreonineBy similarity1
Modified residuei739PhosphoserineBy similarity1
Modified residuei741PhosphoserineCombined sources1
Modified residuei748PhosphotyrosineBy similarity1
Modified residuei825PhosphoserineBy similarity1
Modified residuei884PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1141PhosphoserineCombined sources1
Modified residuei1146PhosphoserineBy similarity1
Modified residuei1161PhosphothreonineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineBy similarity1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1359PhosphothreonineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1562PhosphoserineBy similarity1
Modified residuei1594PhosphoserineBy similarity1
Modified residuei1608PhosphothreonineBy similarity1
Modified residuei1611PhosphothreonineCombined sources1
Modified residuei1622PhosphothreonineCombined sources1
Modified residuei1625PhosphothreonineCombined sources1
Modified residuei1652PhosphothreonineCombined sources1
Modified residuei1656PhosphoserineCombined sources1
Modified residuei1682Phosphoserine; by MARK11 Publication1
Modified residuei1816PhosphoserineCombined sources1
Modified residuei1821PhosphoserineBy similarity1
Modified residuei1824PhosphoserineCombined sources1
Modified residuei1829PhosphoserineCombined sources1
Modified residuei1842PhosphoserineCombined sources1
Isoform 3 (identifier: P15146-3)
Modified residuei319Phosphoserine1 Publication1
Modified residuei350Phosphoserine1 Publication1
Modified residuei382Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 3/MAP2c is probably phosphorylated by PKA at Ser-319, Ser-350 and Ser-382 and by FYN at Tyr-67.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP15146.
PRIDEiP15146.

PTM databases

iPTMnetiP15146.
PhosphoSitePlusiP15146.

Expressioni

Developmental stagei

Isoform 3/MAP2c is expressed during embryonic brain development and until postanatal day 10. Isoform 2 is expressed throughout brain development.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247625. 4 interactors.
IntActiP15146. 4 interactors.
MINTiMINT-261227.
STRINGi10116.ENSRNOP00000050877.

Structurei

3D structure databases

DisProtiDP00122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1664 – 1694Tau/MAP 1Add BLAST31
Repeati1695 – 1725Tau/MAP 2Add BLAST31
Repeati1726 – 1756Tau/MAP 3Add BLAST31
Repeati1757 – 1788Tau/MAP 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1454 – 1474Calmodulin-bindingSequence analysisAdd BLAST21

Sequence similaritiesi

Contains 4 Tau/MAP repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2418. Eukaryota.
ENOG4111J07. LUCA.
HOGENOMiHOG000113477.
HOVERGENiHBG006322.
InParanoidiP15146.
PhylomeDBiP15146.

Family and domain databases

InterProiIPR030797. MAP2.
IPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 1 hit.
PTHR11501:SF15. PTHR11501:SF15. 1 hit.
PfamiPF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 4 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 3 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P15146-1) [UniParc]FASTAAdd to basket
Also known as: MAP2x

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADERKDEGK APHWTSASLT EAAAHPHSPE MKDQGGSGEG LSRSANGFPY
60 70 80 90 100
REEEEGAFGE HGSQGTYSDT KENGINGELT SADRETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQP AALPLAAEET VNLPPSPPPS PASEQTAALE
160 170 180 190 200
EDLLTASKME FPEQQKLPSS FAEPLDKEET EFKMQSKPGE DFEHAALVPQ
210 220 230 240 250
PDTSKTPQDK KDPQDMEGEK SPASPFAQTF GTNLEDIKQI TEPSITVPSI
260 270 280 290 300
GLSAEPLAPK DQKDWFIEMP VESKKDEWGL AAPISPGPLT PMREKDVLED
310 320 330 340 350
IPRWEGKQFD SPMPSPFHGG SFTLPLDTVK DERVTEGSQP FAPVFFQSDD
360 370 380 390 400
KMSLQDTSGS ATSKESSKDE EPQKDKADKV ADVPVSEATT VLGDVHSPAV
410 420 430 440 450
EGFVGENISG EEKGTTDQEK KETSTPSVQE PTLTETEPQT KLEETSKVSI
460 470 480 490 500
EETVAKEEES LKLKDDKAGV IQTSTEQSFS KEDQKGQEQT IEALKQDSFP
510 520 530 540 550
ISLEQAVTDA AMATKTLEKV TSEPEAVSEK REIQGLFEED IADKSKLEGA
560 570 580 590 600
GSATVAEVEM PFYEDKSGMS KYFETSALKE DVTRSTGLGS DYYELSDSRG
610 620 630 640 650
NAQESLDTVS PKNQQDEKEL LAKASQPSPP AHEAGYSTLA QSYTSDHPSE
660 670 680 690 700
LPEEPSSPQE RMFTIDPKVY GEKRDLHSKN KDDLTLSRSL GLGGRSAIEQ
710 720 730 740 750
RSMSINLPMS CLDSIALGFN FGRGHDLSPL ASDILTNTSG SMDEGDDYLP
760 770 780 790 800
PTTPAVEKIP CFPIESKEEE DKTEQAKVTG GQTTQVETSS ESPFPAKEYY
810 820 830 840 850
KNGTVMAPDL PEMLDLAGTR SRLASVSADA EVARRKSVPS EAVVAESSTG
860 870 880 890 900
LPPVADDSQP VKPDSQLEDM GYCVFNKYTV PLPSPVQDSE NLSGESGSFY
910 920 930 940 950
EGTDDKVRRD LATDLSLIEV KLAAAGRVKD EFTAEKEASP PSSADKSGLS
960 970 980 990 1000
REFDQDRKAN DKLDTVLEKS EEHVDSKEHA KESEEVGDKV ELFGLGVTYE
1010 1020 1030 1040 1050
QTSAKELITT KETAPERAEK GLSSVPEVAE VETTTKADQG LDVAAKKDDQ
1060 1070 1080 1090 1100
SPLDIKVSDF GQMASGMSVD AGKTIELKFE VDQQLTLSSE APQETDSFMG
1110 1120 1130 1140 1150
IESSHVKDGA KVSETEVKEK VAKPDLVHQE AVDKEESYES SGEHESLTME
1160 1170 1180 1190 1200
SLKPDEGKKE TSPETSLIQD EVALKLSVEI PCPPPVSEAD SSIDEKAEVQ
1210 1220 1230 1240 1250
MEFIQLPKEE STETPDIPAI PSDVTQPQPE AVVSEPAEVR GEEEEIEAEG
1260 1270 1280 1290 1300
EYDKLLFRSD TLQITDLLVP GSREEFVETC PGEHKGVVES VVTIEDDFIT
1310 1320 1330 1340 1350
VVQTTTDEGE LGSHSVRFAA PVQPEEERRP YPHDEELEVL MAAEAQAEPK
1360 1370 1380 1390 1400
DGSPDAPATP EKEEVPFSEY KTETYDDYKD ETTIDDSIMD ADSLWVDTQD
1410 1420 1430 1440 1450
DDRSILTEQL ETIPKEERAE KEARRPSLEK HRKEKPFKTG RGRISTPERR
1460 1470 1480 1490 1500
EVAKKEPSTV SRDEVRRKKA VYKKAELAKE SEVQAHSPSR KLILKPAIKY
1510 1520 1530 1540 1550
TRPTHLSCVK RKTTATSGES AQAPSAFKQA KDKVTDGITK SPEKRSSLPR
1560 1570 1580 1590 1600
PSSILPPRRG VSGDREENSF SLNSSISSAR RTTRSEPIRR AGKSGTSTPT
1610 1620 1630 1640 1650
TPGSTAITPG TPPSYSSRTP GTPGTPSYPR TPGTPKSGIL VPSEKKVAII
1660 1670 1680 1690 1700
RTPPKSPATP KQLRLINQPL PDLKNVKSKI GSTDNIKYQP KGGQVRILNK
1710 1720 1730 1740 1750
KMDFSKVQSR CGSKDNIKHS AGGGNVQIVT KKIDLSHVTS KCGSLKNIRH
1760 1770 1780 1790 1800
RPGGGRVKIE SVKLDFKEKA QAKVGSLDNA HHVPGGGNVK IDSQKLNFRE
1810 1820 1830 1840 1850
HAKARVDHGA EIITQSPSRS SVASPRRLSN VSSSGSINLL ESPQLATLAE
1860
DVTAALAKQG L
Length:1,861
Mass (Da):202,411
Last modified:June 1, 1994 - v3
Checksum:i42DCF116D21EF54E
GO
Isoform 2 (identifier: P15146-2) [UniParc]FASTAAdd to basket
Also known as: MAP2b

The sequence of this isoform differs from the canonical sequence as follows:
     1695-1725: Missing.

Show »
Length:1,830
Mass (Da):199,053
Checksum:i2A52B720268B0551
GO
Isoform 3 (identifier: P15146-3) [UniParc]FASTAAdd to basket
Also known as: MAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.
     1695-1725: Missing.

Show »
Length:467
Mass (Da):49,300
Checksum:i35ACB5CA6E542606
GO
Isoform 4 (identifier: P15146-4) [UniParc]FASTAAdd to basket
Also known as: MAP2d

The sequence of this isoform differs from the canonical sequence as follows:
     152-1514: Missing.

Show »
Length:498
Mass (Da):52,658
Checksum:iD0CE2BD6CE0ABA3E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003198152 – 1514Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST1363
Alternative sequenceiVSP_0031991695 – 1725Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51842 mRNA. Translation: CAA36135.1.
X17682 mRNA. Translation: CAA35667.1.
X71487 mRNA. Translation: CAA50588.1.
PIRiA37981.
I55502. S33176.
RefSeqiXP_008765430.1. XM_008767208.2. [P15146-3]
UniGeneiRn.10484.
Rn.136301.
Rn.230443.

Genome annotation databases

GeneIDi25595.
UCSCiRGD:3044. rat. [P15146-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51842 mRNA. Translation: CAA36135.1.
X17682 mRNA. Translation: CAA35667.1.
X71487 mRNA. Translation: CAA50588.1.
PIRiA37981.
I55502. S33176.
RefSeqiXP_008765430.1. XM_008767208.2. [P15146-3]
UniGeneiRn.10484.
Rn.136301.
Rn.230443.

3D structure databases

DisProtiDP00122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247625. 4 interactors.
IntActiP15146. 4 interactors.
MINTiMINT-261227.
STRINGi10116.ENSRNOP00000050877.

PTM databases

iPTMnetiP15146.
PhosphoSitePlusiP15146.

Proteomic databases

PaxDbiP15146.
PRIDEiP15146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25595.
UCSCiRGD:3044. rat. [P15146-1]

Organism-specific databases

CTDi4133.
RGDi3044. Map2.

Phylogenomic databases

eggNOGiKOG2418. Eukaryota.
ENOG4111J07. LUCA.
HOGENOMiHOG000113477.
HOVERGENiHBG006322.
InParanoidiP15146.
PhylomeDBiP15146.

Miscellaneous databases

PROiP15146.

Family and domain databases

InterProiIPR030797. MAP2.
IPR027324. MAP2/MAP4/Tau.
IPR013588. MAP2_projctn.
IPR001084. MAP_tubulin-bd_rpt.
[Graphical view]
PANTHERiPTHR11501. PTHR11501. 1 hit.
PTHR11501:SF15. PTHR11501:SF15. 1 hit.
PfamiPF08377. MAP2_projctn. 1 hit.
PF00418. Tubulin-binding. 4 hits.
[Graphical view]
PROSITEiPS00229. TAU_MAP_1. 3 hits.
PS51491. TAU_MAP_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTAP2_RAT
AccessioniPrimary (citable) accession number: P15146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.