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P15143

- PO2F1_CHICK

UniProt

P15143 - PO2F1_CHICK

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Protein

POU domain, class 2, transcription factor 1

Gene

POU2F1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi375 – 43460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name:
Oct-1
Octamer-binding transcription factor 1
Short name:
OTF-1
Gene namesi
Name:POU2F1
Synonyms:OCT1, OTF1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739POU domain, class 2, transcription factor 1PRO_0000100712Add
BLAST

Proteomic databases

PaxDbiP15143.

Interactioni

Subunit structurei

Interacts with NR3C1, AR and PGR.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029768.

Structurei

3D structure databases

ProteinModelPortaliP15143.
SMRiP15143. Positions 275-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 34875POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
HOGENOMiHOG000220842.
HOVERGENiHBG057016.
InParanoidiP15143.
KOiK09364.
PhylomeDBiP15143.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15143-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGPIS TAQAQAFLGH
60 70 80 90 100
LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT
110 120 130 140 150
QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQL LAAAVQHSAS QQHSAAGATI
160 170 180 190 200
SASAATPMTQ IPLSQPIQIA QHLQQLQQQN LNLQQFVLVH PTTNLQPAQF
210 220 230 240 250
IISQTPQGQQ GLLQAQNLLT QLPQQSQANL LQSQPSITLA SQPATPTRTI
260 270 280 290 300
AATPIQPLPQ SQSTPKRIDT PSLEEPSDLE ELEQFAKTFK QRRIKLGFTQ
310 320 330 340 350
GDVGLAMGKL YGNDFSQTTI SRFEALNLSF KNMCKLKPLL EKWLNDAENL
360 370 380 390 400
SSDSTLSSPS ALNSPGQGIE GVNRRRKKRT SIETNIRVAL EKSFLENQKP
410 420 430 440 450
TSEEITMIAD QLNMEKEVIR VWFCNRRQKE KRINPPSSGG TSSSPIKAIF
460 470 480 490 500
PSPTSLVATT PSLVTSSAAT TLTVNPVLPL TSPAVTSLSV TGTTETTSNN
510 520 530 540 550
TATVISTAPP ASSAVTSPSL SPSPSASASI SEASSASETS TTQTTSTPLS
560 570 580 590 600
SPLGTSQVMV TASGLQTAAA AALQGAAQLP ANASLAAMAA AAGLNPGLMA
610 620 630 640 650
SSQFAAGGAL LSLNPGTLGG ALSPALMSNS TLATIQALAS SGSLPITSLD
660 670 680 690 700
ASGNLVFANA GGTPNIVTAP LFLNPQNLSL LTSNPVSLVS AAAASAGASG
710 720 730
PVASLHATST SAESIQNSLL TVASASGATS TTTTASKAQ
Length:739
Mass (Da):75,982
Last modified:April 1, 1990 - v1
Checksum:i815A2AD8F55D6FE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29972 mRNA. Translation: AAA48993.1.
PIRiA34873.
RefSeqiNP_990803.1. NM_205472.1.
UniGeneiGga.836.

Genome annotation databases

GeneIDi396463.
KEGGigga:396463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29972 mRNA. Translation: AAA48993.1 .
PIRi A34873.
RefSeqi NP_990803.1. NM_205472.1.
UniGenei Gga.836.

3D structure databases

ProteinModelPortali P15143.
SMRi P15143. Positions 275-435.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000029768.

Proteomic databases

PaxDbi P15143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396463.
KEGGi gga:396463.

Organism-specific databases

CTDi 5451.

Phylogenomic databases

eggNOGi NOG267922.
HOGENOMi HOG000220842.
HOVERGENi HBG057016.
InParanoidi P15143.
KOi K09364.
PhylomeDBi P15143.

Miscellaneous databases

NextBioi 20816502.
PROi P15143.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution."
    Petryniak B., Staudt L.M., Postema C.E., McCormack W.T., Thompson C.B.
    Proc. Natl. Acad. Sci. U.S.A. 87:1099-1103(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPO2F1_CHICK
AccessioniPrimary (citable) accession number: P15143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3