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P15143

- PO2F1_CHICK

UniProt

P15143 - PO2F1_CHICK

Protein

POU domain, class 2, transcription factor 1

Gene

POU2F1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi375 – 43460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 1
    Alternative name(s):
    NF-A1
    Octamer-binding protein 1
    Short name:
    Oct-1
    Octamer-binding transcription factor 1
    Short name:
    OTF-1
    Gene namesi
    Name:POU2F1
    Synonyms:OCT1, OTF1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739POU domain, class 2, transcription factor 1PRO_0000100712Add
    BLAST

    Proteomic databases

    PaxDbiP15143.

    Interactioni

    Subunit structurei

    Interacts with NR3C1, AR and PGR.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000029768.

    Structurei

    3D structure databases

    ProteinModelPortaliP15143.
    SMRiP15143. Positions 275-435.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini274 – 34875POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOGENOMiHOG000220842.
    HOVERGENiHBG057016.
    KOiK09364.
    PhylomeDBiP15143.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15143-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGPIS TAQAQAFLGH    50
    LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT 100
    QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQL LAAAVQHSAS QQHSAAGATI 150
    SASAATPMTQ IPLSQPIQIA QHLQQLQQQN LNLQQFVLVH PTTNLQPAQF 200
    IISQTPQGQQ GLLQAQNLLT QLPQQSQANL LQSQPSITLA SQPATPTRTI 250
    AATPIQPLPQ SQSTPKRIDT PSLEEPSDLE ELEQFAKTFK QRRIKLGFTQ 300
    GDVGLAMGKL YGNDFSQTTI SRFEALNLSF KNMCKLKPLL EKWLNDAENL 350
    SSDSTLSSPS ALNSPGQGIE GVNRRRKKRT SIETNIRVAL EKSFLENQKP 400
    TSEEITMIAD QLNMEKEVIR VWFCNRRQKE KRINPPSSGG TSSSPIKAIF 450
    PSPTSLVATT PSLVTSSAAT TLTVNPVLPL TSPAVTSLSV TGTTETTSNN 500
    TATVISTAPP ASSAVTSPSL SPSPSASASI SEASSASETS TTQTTSTPLS 550
    SPLGTSQVMV TASGLQTAAA AALQGAAQLP ANASLAAMAA AAGLNPGLMA 600
    SSQFAAGGAL LSLNPGTLGG ALSPALMSNS TLATIQALAS SGSLPITSLD 650
    ASGNLVFANA GGTPNIVTAP LFLNPQNLSL LTSNPVSLVS AAAASAGASG 700
    PVASLHATST SAESIQNSLL TVASASGATS TTTTASKAQ 739
    Length:739
    Mass (Da):75,982
    Last modified:April 1, 1990 - v1
    Checksum:i815A2AD8F55D6FE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29972 mRNA. Translation: AAA48993.1.
    PIRiA34873.
    RefSeqiNP_990803.1. NM_205472.1.
    UniGeneiGga.836.

    Genome annotation databases

    GeneIDi396463.
    KEGGigga:396463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29972 mRNA. Translation: AAA48993.1 .
    PIRi A34873.
    RefSeqi NP_990803.1. NM_205472.1.
    UniGenei Gga.836.

    3D structure databases

    ProteinModelPortali P15143.
    SMRi P15143. Positions 275-435.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000029768.

    Proteomic databases

    PaxDbi P15143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396463.
    KEGGi gga:396463.

    Organism-specific databases

    CTDi 5451.

    Phylogenomic databases

    eggNOGi NOG267922.
    HOGENOMi HOG000220842.
    HOVERGENi HBG057016.
    KOi K09364.
    PhylomeDBi P15143.

    Miscellaneous databases

    NextBioi 20816502.
    PROi P15143.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution."
      Petryniak B., Staudt L.M., Postema C.E., McCormack W.T., Thompson C.B.
      Proc. Natl. Acad. Sci. U.S.A. 87:1099-1103(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPO2F1_CHICK
    AccessioniPrimary (citable) accession number: P15143
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3