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P15143 (PO2F1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 2, transcription factor 1
Alternative name(s):
NF-A1
Octamer-binding protein 1
Short name=Oct-1
Octamer-binding transcription factor 1
Short name=OTF-1
Gene names
Name:POU2F1
Synonyms:OCT1, OTF1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity.

Subunit structure

Interacts with NR3C1, AR and PGR By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739POU domain, class 2, transcription factor 1
PRO_0000100712

Regions

Domain274 – 34875POU-specific
DNA binding375 – 43460Homeobox

Sequences

Sequence LengthMass (Da)Tools
P15143 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 815A2AD8F55D6FE2

FASTA73975,982
        10         20         30         40         50         60 
MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGPIS TAQAQAFLGH LHQVQLAGTS 

        70         80         90        100        110        120 
LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ 

       130        140        150        160        170        180 
LLLQQAQAQL LAAAVQHSAS QQHSAAGATI SASAATPMTQ IPLSQPIQIA QHLQQLQQQN 

       190        200        210        220        230        240 
LNLQQFVLVH PTTNLQPAQF IISQTPQGQQ GLLQAQNLLT QLPQQSQANL LQSQPSITLA 

       250        260        270        280        290        300 
SQPATPTRTI AATPIQPLPQ SQSTPKRIDT PSLEEPSDLE ELEQFAKTFK QRRIKLGFTQ 

       310        320        330        340        350        360 
GDVGLAMGKL YGNDFSQTTI SRFEALNLSF KNMCKLKPLL EKWLNDAENL SSDSTLSSPS 

       370        380        390        400        410        420 
ALNSPGQGIE GVNRRRKKRT SIETNIRVAL EKSFLENQKP TSEEITMIAD QLNMEKEVIR 

       430        440        450        460        470        480 
VWFCNRRQKE KRINPPSSGG TSSSPIKAIF PSPTSLVATT PSLVTSSAAT TLTVNPVLPL 

       490        500        510        520        530        540 
TSPAVTSLSV TGTTETTSNN TATVISTAPP ASSAVTSPSL SPSPSASASI SEASSASETS 

       550        560        570        580        590        600 
TTQTTSTPLS SPLGTSQVMV TASGLQTAAA AALQGAAQLP ANASLAAMAA AAGLNPGLMA 

       610        620        630        640        650        660 
SSQFAAGGAL LSLNPGTLGG ALSPALMSNS TLATIQALAS SGSLPITSLD ASGNLVFANA 

       670        680        690        700        710        720 
GGTPNIVTAP LFLNPQNLSL LTSNPVSLVS AAAASAGASG PVASLHATST SAESIQNSLL 

       730 
TVASASGATS TTTTASKAQ 

« Hide

References

[1]"Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution."
Petryniak B., Staudt L.M., Postema C.E., McCormack W.T., Thompson C.B.
Proc. Natl. Acad. Sci. U.S.A. 87:1099-1103(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29972 mRNA. Translation: AAA48993.1.
PIRA34873.
RefSeqNP_990803.1. NM_205472.1.
UniGeneGga.836.

3D structure databases

ProteinModelPortalP15143.
SMRP15143. Positions 275-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000029768.

Proteomic databases

PaxDbP15143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396463.
KEGGgga:396463.

Organism-specific databases

CTD5451.

Phylogenomic databases

eggNOGNOG267922.
HOGENOMHOG000220842.
HOVERGENHBG057016.
KOK09364.
PhylomeDBP15143.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00029. OCTAMER.
PR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816502.
PROP15143.

Entry information

Entry namePO2F1_CHICK
AccessionPrimary (citable) accession number: P15143
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families