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P15129

- CP4B1_RAT

UniProt

P15129 - CP4B1_RAT

Protein

Cytochrome P450 4B1

Gene

Cyp4b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei315 – 3151Heme (covalent; via 1 link)By similarity
    Metal bindingi453 – 4531Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. drug binding Source: RGD
    3. fluorene oxygenase activity Source: RGD
    4. heme binding Source: InterPro
    5. iron ion binding Source: InterPro
    6. monooxygenase activity Source: RGD

    GO - Biological processi

    1. biphenyl metabolic process Source: RGD
    2. cellular aromatic compound metabolic process Source: RGD
    3. exogenous drug catabolic process Source: RGD
    4. fluorene metabolic process Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4B1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVB1
    Cytochrome P450 L-2
    Cytochrome P450 isozyme 5
    Gene namesi
    Name:Cyp4b1
    Synonyms:Cyp4b-1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi2480. Cyp4b1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 511510Cytochrome P450 4B1PRO_0000051822Add
    BLAST

    Proteomic databases

    PRIDEiP15129.

    PTM databases

    PhosphoSiteiP15129.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    GenevestigatoriP15129.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013321.

    Structurei

    3D structure databases

    ProteinModelPortaliP15129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00740000115505.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiP15129.
    KOiK07426.
    OMAiDSTHAML.
    PhylomeDBiP15129.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15129-1 [UniParc]FASTAAdd to Basket

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    MVLNFLSPSL SRLGLWASVV ILMVIVLKLF SLLLRRQKLA RAMDSFPGPP    50
    THWLFGHALE IQKLGSLDKV VSWAQQFPHA HPLWFGQFVG FLNIYEPDYA 100
    KAVYSRGDPK AADVYDFFLQ WIGKGLLVLD GPKWFQHRKL LTPGFHYDVL 150
    KPYVAIFAES TRMMLDKWEK KASENKSFDI FCDVGHMALD TLMKCTFGKG 200
    DSGLGHRDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT PHGRRFLRAC 250
    KIAHDHTDEV IRQRKAALQD EKERKKIQQR RHLDFLDILL GVRDESGIKL 300
    SDAELRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQQL CREEVRGILG 350
    DQDSFQWDDL AKMTYLTMCM KECFRLYPPV PQVYRQLNKP VTFVDGRSLP 400
    AGSLISLHIY ALHRNSTVWP DPEVFDPLRF SPENAAGRHP FAFMPFSAGP 450
    RNCIGQQFAM NEMKVVTALC LLRFEFSLDP SKMPIKVPQL ILRSKNGIHL 500
    YLKPLASRSG K 511
    Length:511
    Mass (Da):58,936
    Last modified:January 23, 2007 - v3
    Checksum:iCEAAFB5BE2ED9944
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29853 mRNA. Translation: AAA41778.1.
    BC074012 mRNA. Translation: AAH74012.1.
    PIRiB40164.
    RefSeqiNP_058695.2. NM_016999.2.
    UniGeneiRn.86651.

    Genome annotation databases

    EnsembliENSRNOT00000013321; ENSRNOP00000013321; ENSRNOG00000009741.
    GeneIDi24307.
    KEGGirno:24307.
    UCSCiRGD:2480. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29853 mRNA. Translation: AAA41778.1 .
    BC074012 mRNA. Translation: AAH74012.1 .
    PIRi B40164.
    RefSeqi NP_058695.2. NM_016999.2.
    UniGenei Rn.86651.

    3D structure databases

    ProteinModelPortali P15129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013321.

    PTM databases

    PhosphoSitei P15129.

    Proteomic databases

    PRIDEi P15129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013321 ; ENSRNOP00000013321 ; ENSRNOG00000009741 .
    GeneIDi 24307.
    KEGGi rno:24307.
    UCSCi RGD:2480. rat.

    Organism-specific databases

    CTDi 1580.
    RGDi 2480. Cyp4b1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00740000115505.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi P15129.
    KOi K07426.
    OMAi DSTHAML.
    PhylomeDBi P15129.

    Miscellaneous databases

    NextBioi 602935.
    PROi P15129.

    Gene expression databases

    Genevestigatori P15129.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB."
      Gasser R., Philpot R.M.
      Mol. Pharmacol. 35:617-625(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    3. "Purification and characterization of rat pulmonary cytochrome P-450."
      Imaoka S., Funae Y.
      J. Biochem. 108:33-36(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-11.
      Tissue: Lung.

    Entry informationi

    Entry nameiCP4B1_RAT
    AccessioniPrimary (citable) accession number: P15129
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3