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P15129 (CP4B1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4B1

EC=1.14.14.1
Alternative name(s):
CYPIVB1
Cytochrome P450 L-2
Cytochrome P450 isozyme 5
Gene names
Name:Cyp4b1
Synonyms:Cyp4b-1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 511510Cytochrome P450 4B1
PRO_0000051822

Sites

Metal binding4531Iron (heme axial ligand) By similarity
Binding site3151Heme (covalent; via 1 link) By similarity

Sequences

Sequence LengthMass (Da)Tools
P15129 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: CEAAFB5BE2ED9944

FASTA51158,936
        10         20         30         40         50         60 
MVLNFLSPSL SRLGLWASVV ILMVIVLKLF SLLLRRQKLA RAMDSFPGPP THWLFGHALE 

        70         80         90        100        110        120 
IQKLGSLDKV VSWAQQFPHA HPLWFGQFVG FLNIYEPDYA KAVYSRGDPK AADVYDFFLQ 

       130        140        150        160        170        180 
WIGKGLLVLD GPKWFQHRKL LTPGFHYDVL KPYVAIFAES TRMMLDKWEK KASENKSFDI 

       190        200        210        220        230        240 
FCDVGHMALD TLMKCTFGKG DSGLGHRDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT 

       250        260        270        280        290        300 
PHGRRFLRAC KIAHDHTDEV IRQRKAALQD EKERKKIQQR RHLDFLDILL GVRDESGIKL 

       310        320        330        340        350        360 
SDAELRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQQL CREEVRGILG DQDSFQWDDL 

       370        380        390        400        410        420 
AKMTYLTMCM KECFRLYPPV PQVYRQLNKP VTFVDGRSLP AGSLISLHIY ALHRNSTVWP 

       430        440        450        460        470        480 
DPEVFDPLRF SPENAAGRHP FAFMPFSAGP RNCIGQQFAM NEMKVVTALC LLRFEFSLDP 

       490        500        510 
SKMPIKVPQL ILRSKNGIHL YLKPLASRSG K 

« Hide

References

« Hide 'large scale' references
[1]"Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB."
Gasser R., Philpot R.M.
Mol. Pharmacol. 35:617-625(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[3]"Purification and characterization of rat pulmonary cytochrome P-450."
Imaoka S., Funae Y.
J. Biochem. 108:33-36(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-11.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29853 mRNA. Translation: AAA41778.1.
BC074012 mRNA. Translation: AAH74012.1.
PIRB40164.
RefSeqNP_058695.2. NM_016999.2.
UniGeneRn.86651.

3D structure databases

ProteinModelPortalP15129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000013321.

PTM databases

PhosphoSiteP15129.

Proteomic databases

PRIDEP15129.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013321; ENSRNOP00000013321; ENSRNOG00000009741.
GeneID24307.
KEGGrno:24307.
UCSCRGD:2480. rat.

Organism-specific databases

CTD1580.
RGD2480. Cyp4b1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00740000115505.
HOGENOMHOG000233833.
HOVERGENHBG000182.
InParanoidP15129.
KOK07426.
OMADSTHAML.
PhylomeDBP15129.

Gene expression databases

GenevestigatorP15129.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio602935.
PROP15129.

Entry information

Entry nameCP4B1_RAT
AccessionPrimary (citable) accession number: P15129
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families