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P15129

- CP4B1_RAT

UniProt

P15129 - CP4B1_RAT

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Protein
Cytochrome P450 4B1
Gene
Cyp4b1, Cyp4b-1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei315 – 3151Heme (covalent; via 1 link) By similarity
Metal bindingi453 – 4531Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. drug binding Source: RGD
  3. fluorene oxygenase activity Source: RGD
  4. heme binding Source: InterPro
  5. iron ion binding Source: InterPro
  6. monooxygenase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. biphenyl metabolic process Source: RGD
  2. cellular aromatic compound metabolic process Source: RGD
  3. exogenous drug catabolic process Source: RGD
  4. fluorene metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4B1 (EC:1.14.14.1)
Alternative name(s):
CYPIVB1
Cytochrome P450 L-2
Cytochrome P450 isozyme 5
Gene namesi
Name:Cyp4b1
Synonyms:Cyp4b-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi2480. Cyp4b1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 511510Cytochrome P450 4B1
PRO_0000051822Add
BLAST

Proteomic databases

PRIDEiP15129.

PTM databases

PhosphoSiteiP15129.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP15129.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013321.

Structurei

3D structure databases

ProteinModelPortaliP15129.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00740000115505.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP15129.
KOiK07426.
OMAiDSTHAML.
PhylomeDBiP15129.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15129-1 [UniParc]FASTAAdd to Basket

« Hide

MVLNFLSPSL SRLGLWASVV ILMVIVLKLF SLLLRRQKLA RAMDSFPGPP    50
THWLFGHALE IQKLGSLDKV VSWAQQFPHA HPLWFGQFVG FLNIYEPDYA 100
KAVYSRGDPK AADVYDFFLQ WIGKGLLVLD GPKWFQHRKL LTPGFHYDVL 150
KPYVAIFAES TRMMLDKWEK KASENKSFDI FCDVGHMALD TLMKCTFGKG 200
DSGLGHRDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT PHGRRFLRAC 250
KIAHDHTDEV IRQRKAALQD EKERKKIQQR RHLDFLDILL GVRDESGIKL 300
SDAELRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQQL CREEVRGILG 350
DQDSFQWDDL AKMTYLTMCM KECFRLYPPV PQVYRQLNKP VTFVDGRSLP 400
AGSLISLHIY ALHRNSTVWP DPEVFDPLRF SPENAAGRHP FAFMPFSAGP 450
RNCIGQQFAM NEMKVVTALC LLRFEFSLDP SKMPIKVPQL ILRSKNGIHL 500
YLKPLASRSG K 511
Length:511
Mass (Da):58,936
Last modified:January 23, 2007 - v3
Checksum:iCEAAFB5BE2ED9944
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29853 mRNA. Translation: AAA41778.1.
BC074012 mRNA. Translation: AAH74012.1.
PIRiB40164.
RefSeqiNP_058695.2. NM_016999.2.
UniGeneiRn.86651.

Genome annotation databases

EnsembliENSRNOT00000013321; ENSRNOP00000013321; ENSRNOG00000009741.
GeneIDi24307.
KEGGirno:24307.
UCSCiRGD:2480. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29853 mRNA. Translation: AAA41778.1 .
BC074012 mRNA. Translation: AAH74012.1 .
PIRi B40164.
RefSeqi NP_058695.2. NM_016999.2.
UniGenei Rn.86651.

3D structure databases

ProteinModelPortali P15129.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013321.

PTM databases

PhosphoSitei P15129.

Proteomic databases

PRIDEi P15129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013321 ; ENSRNOP00000013321 ; ENSRNOG00000009741 .
GeneIDi 24307.
KEGGi rno:24307.
UCSCi RGD:2480. rat.

Organism-specific databases

CTDi 1580.
RGDi 2480. Cyp4b1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00740000115505.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi P15129.
KOi K07426.
OMAi DSTHAML.
PhylomeDBi P15129.

Miscellaneous databases

NextBioi 602935.
PROi P15129.

Gene expression databases

Genevestigatori P15129.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB."
    Gasser R., Philpot R.M.
    Mol. Pharmacol. 35:617-625(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. "Purification and characterization of rat pulmonary cytochrome P-450."
    Imaoka S., Funae Y.
    J. Biochem. 108:33-36(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11.
    Tissue: Lung.

Entry informationi

Entry nameiCP4B1_RAT
AccessioniPrimary (citable) accession number: P15129
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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