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Protein

Cytochrome P450 4B1

Gene

CYP4B1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei310Heme (covalent; via 1 link)By similarity1
Metal bindingi448Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4B1 (EC:1.14.14.1)
Alternative name(s):
CYPIVB1
Cytochrome P450 isozyme 5
Gene namesi
Name:CYP4B1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518211 – 506Cytochrome P450 4B1Add BLAST506

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000009637.

Structurei

Secondary structure

1506
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 38Combined sources18
Turni48 – 50Combined sources3
Helixi53 – 56Combined sources4
Helixi61 – 71Combined sources11
Beta strandi72 – 83Combined sources12
Beta strandi85 – 89Combined sources5
Helixi92 – 99Combined sources8
Helixi107 – 110Combined sources4
Helixi111 – 113Combined sources3
Turni114 – 116Combined sources3
Turni121 – 123Combined sources3
Helixi127 – 136Combined sources10
Helixi142 – 145Combined sources4
Helixi148 – 167Combined sources20
Turni168 – 170Combined sources3
Helixi176 – 191Combined sources16
Helixi202 – 222Combined sources21
Helixi224 – 226Combined sources3
Helixi229 – 232Combined sources4
Helixi236 – 262Combined sources27
Turni263 – 265Combined sources3
Helixi267 – 270Combined sources4
Helixi280 – 285Combined sources6
Helixi287 – 289Combined sources3
Helixi297 – 328Combined sources32
Helixi330 – 344Combined sources15
Helixi352 – 355Combined sources4
Helixi359 – 371Combined sources13
Beta strandi377 – 381Combined sources5
Beta strandi399 – 403Combined sources5
Helixi404 – 407Combined sources4
Turni411 – 413Combined sources3
Beta strandi414 – 416Combined sources3
Helixi422 – 425Combined sources4
Turni427 – 432Combined sources6
Helixi444 – 446Combined sources3
Helixi451 – 468Combined sources18
Beta strandi469 – 472Combined sources4
Beta strandi481 – 489Combined sources9
Beta strandi494 – 499Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T6QX-ray2.70A20-506[»]
ProteinModelPortaliP15128.
SMRiP15128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP15128.
KOiK07426.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P15128-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGFLSRLGL WASGLILILG FLKLLRLLLR RQRLARAMDS FPGPPTHWLF
60 70 80 90 100
GHALEIQKTG SLDKVVTWTQ QFPYAHPLWV GQFIGFLNIY EPDYAKAVYS
110 120 130 140 150
RGDPKAPDVY DFFLQWIGKG LLVLDGPKWF QHRKLLTPGF HYDVLKPYVA
160 170 180 190 200
IFADSTRIML EKWEKKACEG KSFDIFSDVG HMALDTLMKC TFGKGDSGLN
210 220 230 240 250
HRDSSYYVAV SELTLLMQQR IDSFQYHNDF IYWLTPHGRR FLRACRAAHD
260 270 280 290 300
HTDRVIRQRK AALQDEKERE KIQNRRHLDF LDILLDVRGE SGVQLSDTDL
310 320 330 340 350
RAEVDTFMFE GHDTTTSGIS WFLYCMALYP EHQQRCREEV REILGDQDSF
360 370 380 390 400
QWEDLAKMTY LTMCMKECFR LYPPVPQVYR QLSKPVSFVD GRSLPAGSLI
410 420 430 440 450
SLHIYALHRN SDVWPDPEVF DPLRFSPENS SGRHPYAFIP FSAGPRNCIG
460 470 480 490 500
QQFAMNEMKV VTALCLLRFE FSVDPLRLPI KLPQLVLRSK NGIHLYLKPL

GPKAEK
Length:506
Mass (Da):58,604
Last modified:April 1, 1990 - v1
Checksum:iEB406EB7453A53CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29852 mRNA. Translation: AAA31214.1.
AF176914 mRNA. Translation: AAD52658.4.
AF332576 mRNA. Translation: AAG52885.1.
PIRiA40164.
RefSeqiNP_001075572.1. NM_001082103.1.
UniGeneiOcu.1854.

Genome annotation databases

GeneIDi100008805.
KEGGiocu:100008805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29852 mRNA. Translation: AAA31214.1.
AF176914 mRNA. Translation: AAD52658.4.
AF332576 mRNA. Translation: AAG52885.1.
PIRiA40164.
RefSeqiNP_001075572.1. NM_001082103.1.
UniGeneiOcu.1854.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T6QX-ray2.70A20-506[»]
ProteinModelPortaliP15128.
SMRiP15128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000009637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008805.
KEGGiocu:100008805.

Organism-specific databases

CTDi1580.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP15128.
KOiK07426.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCP4B1_RABIT
AccessioniPrimary (citable) accession number: P15128
Secondary accession number(s): Q9TU22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 10, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.