Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P15128

- CP4B1_RABIT

UniProt

P15128 - CP4B1_RABIT

Protein

Cytochrome P450 4B1

Gene

CYP4B1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei310 – 3101Heme (covalent; via 1 link)By similarity
    Metal bindingi448 – 4481Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4B1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVB1
    Cytochrome P450 isozyme 5
    Gene namesi
    Name:CYP4B1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Cytochrome P450 4B1PRO_0000051821Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000009637.

    Structurei

    3D structure databases

    ProteinModelPortaliP15128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15128-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGFLSRLGL WASGLILILG FLKLLRLLLR RQRLARAMDS FPGPPTHWLF    50
    GHALEIQKTG SLDKVVTWTQ QFPYAHPLWV GQFIGFLNIY EPDYAKAVYS 100
    RGDPKAPDVY DFFLQWIGKG LLVLDGPKWF QHRKLLTPGF HYDVLKPYVA 150
    IFADSTRIML EKWEKKACEG KSFDIFSDVG HMALDTLMKC TFGKGDSGLN 200
    HRDSSYYVAV SELTLLMQQR IDSFQYHNDF IYWLTPHGRR FLRACRAAHD 250
    HTDRVIRQRK AALQDEKERE KIQNRRHLDF LDILLDVRGE SGVQLSDTDL 300
    RAEVDTFMFE GHDTTTSGIS WFLYCMALYP EHQQRCREEV REILGDQDSF 350
    QWEDLAKMTY LTMCMKECFR LYPPVPQVYR QLSKPVSFVD GRSLPAGSLI 400
    SLHIYALHRN SDVWPDPEVF DPLRFSPENS SGRHPYAFIP FSAGPRNCIG 450
    QQFAMNEMKV VTALCLLRFE FSVDPLRLPI KLPQLVLRSK NGIHLYLKPL 500
    GPKAEK 506
    Length:506
    Mass (Da):58,604
    Last modified:April 1, 1990 - v1
    Checksum:iEB406EB7453A53CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29852 mRNA. Translation: AAA31214.1.
    AF176914 mRNA. Translation: AAD52658.4.
    AF332576 mRNA. Translation: AAG52885.1.
    PIRiA40164.
    RefSeqiNP_001075572.1. NM_001082103.1.
    UniGeneiOcu.1854.

    Genome annotation databases

    GeneIDi100008805.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29852 mRNA. Translation: AAA31214.1 .
    AF176914 mRNA. Translation: AAD52658.4 .
    AF332576 mRNA. Translation: AAG52885.1 .
    PIRi A40164.
    RefSeqi NP_001075572.1. NM_001082103.1.
    UniGenei Ocu.1854.

    3D structure databases

    ProteinModelPortali P15128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000009637.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100008805.

    Organism-specific databases

    CTDi 1580.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB."
      Gasser R., Philpot R.M.
      Mol. Pharmacol. 35:617-625(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Rabbit corneal hypoxia-inducible CYP4B1-like isoform, 3'-coding and noncoding regions."
      Mastyugin V., Schwartzman M.L.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Corneal epithelium.
    3. "Cytochrome P-450 isozymes 2 and 5 in rabbit lung and liver. Comparisons of structure and inducibility."
      Parandoosh Z., Fujita V.S., Coon M.J., Philpot R.M.
      Drug Metab. Dispos. 15:59-67(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-21.

    Entry informationi

    Entry nameiCP4B1_RABIT
    AccessioniPrimary (citable) accession number: P15128
    Secondary accession number(s): Q9TU22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3