Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P15128 (CP4B1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4B1

EC=1.14.14.1
Alternative name(s):
CYPIVB1
Cytochrome P450 isozyme 5
Gene names
Name:CYP4B1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Cytochrome P450 4B1
PRO_0000051821

Sites

Metal binding4481Iron (heme axial ligand)
Binding site3101Heme (covalent; via 1 link) By similarity

Sequences

Sequence LengthMass (Da)Tools
P15128 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: EB406EB7453A53CB

FASTA50658,604
        10         20         30         40         50         60 
MLGFLSRLGL WASGLILILG FLKLLRLLLR RQRLARAMDS FPGPPTHWLF GHALEIQKTG 

        70         80         90        100        110        120 
SLDKVVTWTQ QFPYAHPLWV GQFIGFLNIY EPDYAKAVYS RGDPKAPDVY DFFLQWIGKG 

       130        140        150        160        170        180 
LLVLDGPKWF QHRKLLTPGF HYDVLKPYVA IFADSTRIML EKWEKKACEG KSFDIFSDVG 

       190        200        210        220        230        240 
HMALDTLMKC TFGKGDSGLN HRDSSYYVAV SELTLLMQQR IDSFQYHNDF IYWLTPHGRR 

       250        260        270        280        290        300 
FLRACRAAHD HTDRVIRQRK AALQDEKERE KIQNRRHLDF LDILLDVRGE SGVQLSDTDL 

       310        320        330        340        350        360 
RAEVDTFMFE GHDTTTSGIS WFLYCMALYP EHQQRCREEV REILGDQDSF QWEDLAKMTY 

       370        380        390        400        410        420 
LTMCMKECFR LYPPVPQVYR QLSKPVSFVD GRSLPAGSLI SLHIYALHRN SDVWPDPEVF 

       430        440        450        460        470        480 
DPLRFSPENS SGRHPYAFIP FSAGPRNCIG QQFAMNEMKV VTALCLLRFE FSVDPLRLPI 

       490        500 
KLPQLVLRSK NGIHLYLKPL GPKAEK 

« Hide

References

[1]"Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB."
Gasser R., Philpot R.M.
Mol. Pharmacol. 35:617-625(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Rabbit corneal hypoxia-inducible CYP4B1-like isoform, 3'-coding and noncoding regions."
Mastyugin V., Schwartzman M.L.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Corneal epithelium.
[3]"Cytochrome P-450 isozymes 2 and 5 in rabbit lung and liver. Comparisons of structure and inducibility."
Parandoosh Z., Fujita V.S., Coon M.J., Philpot R.M.
Drug Metab. Dispos. 15:59-67(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-21.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29852 mRNA. Translation: AAA31214.1.
AF176914 mRNA. Translation: AAD52658.4.
AF332576 mRNA. Translation: AAG52885.1.
PIRA40164.
RefSeqNP_001075572.1. NM_001082103.1.
UniGeneOcu.1854.

3D structure databases

ProteinModelPortalP15128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000009637.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100008805.

Organism-specific databases

CTD1580.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000233833.
HOVERGENHBG000182.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP4B1_RABIT
AccessionPrimary (citable) accession number: P15128
Secondary accession number(s): Q9TU22
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: December 11, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families