SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P15124

- GLNA_METCA

UniProt

P15124 - GLNA_METCA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutamine synthetase
Gene
glnA, MCA1677
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:MCA1677
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Glutamine synthetase
PRO_0000153243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei398 – 3981O-AMP-tyrosine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.

Protein-protein interaction databases

STRINGi243233.MCA1677.

Structurei

3D structure databases

ProteinModelPortaliP15124.
SMRiP15124. Positions 2-469.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiDMLLMPI.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15124-1 [UniParc]FASTAAdd to Basket

« Hide

MTPKDVLQII KEKEVRYVDL RFADTRGKEQ HVTVPASTID EAAFEEGKMF    50
DGSSIAGWKG INESDMILMP DASTAVMDPF FDDPTLILRC DIVEPATMQG 100
YERDPRSIAK RAEAYMKSTG IADTALFGPE NEFFIFDDVR WGANMSGSFY 150
KVDSEEAGWN SEKVYEDGNI GHRPGVKGGY FPVPPVDSFQ DLRSAMCNTL 200
EDMGMVVEVH HHEVATAGQC EIGVRCNTLV KKADEVLLLK YAVQNVAHAY 250
GKTATFMPKP LVGDNGNGMH VHQSLAKDGK NLFSGDLYGG LSETALHYIG 300
GIIKHAKALN AFCNASTNSY KRLVPGFEAP VMLAYSARNR SASIRIPYVM 350
NPKARRIEVR FPDSTANPYL AFAAMLMAGL DGIQNKIHPG DAMDKDLYDL 400
PPEEEKAIPQ VCYSFDQALE ALDKDREFLT RGGVFTDDMI DAYLDLKGQE 450
VTRLRMSTHP VEFDMYYSL 469
Length:469
Mass (Da):52,089
Last modified:December 7, 2004 - v2
Checksum:i652DFDF8405AFFFB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti264 – 2641D → A in AAA25312. 1 Publication
Sequence conflicti275 – 2751L → V in AAA25312. 1 Publication
Sequence conflicti302 – 3065IIKHA → YISMP in AAA25312. 1 Publication
Sequence conflicti345 – 3451R → G in AAA25312. 1 Publication
Sequence conflicti453 – 4608RLRMSTHP → ACDEHSS in AAA25312. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28472 Genomic DNA. Translation: AAA25312.1.
AE017282 Genomic DNA. Translation: AAU92104.1.
PIRiA37176.
RefSeqiWP_010960935.1. NC_002977.6.
YP_114120.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU92104; AAU92104; MCA1677.
GeneIDi3103018.
KEGGimca:MCA1677.
PATRICi22607194. VBIMetCap22254_1706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28472 Genomic DNA. Translation: AAA25312.1 .
AE017282 Genomic DNA. Translation: AAU92104.1 .
PIRi A37176.
RefSeqi WP_010960935.1. NC_002977.6.
YP_114120.1. NC_002977.6.

3D structure databases

ProteinModelPortali P15124.
SMRi P15124. Positions 2-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243233.MCA1677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU92104 ; AAU92104 ; MCA1677 .
GeneIDi 3103018.
KEGGi mca:MCA1677.
PATRICi 22607194. VBIMetCap22254_1706.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000005157.
KOi K01915.
OMAi DMLLMPI.
OrthoDBi EOG6B360N.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and expression of the glutamine synthetase structural gene (glnA) from the obligate methanotroph Methylococcus capsulatus (Bath)."
    Cardy D.L.N., Murrell J.C.
    J. Gen. Microbiol. 136:343-352(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiGLNA_METCA
AccessioniPrimary (citable) accession number: P15124
Secondary accession number(s): Q607S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi