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P15123 (CP2CG_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C16

EC=1.14.14.1
Alternative name(s):
CYPIIC16
Gene names
Name:CYP2C16
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Expressed constitutively in liver, lung, testes, and kidney.

Induction

By phenobarbital in each tissue with the exception of the kidney.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Cytochrome P450 2C16
PRO_0000051706

Sites

Metal binding4321Iron (heme axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P15123 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: F282245DA3CB90A2

FASTA48755,542
        10         20         30         40         50         60 
MDPVVVLVLG LCCLLLLSHW KQNSGRGKLP PGPTPFPIIG NILQIDAKDI SKSLTKFSER 

        70         80         90        100        110        120 
YGPVFTVYLG MKPAVVLHGY QAVKEALVDL GEEFAGRGSF PMLDKVSKGL GIVFTNGKRW 

       130        140        150        160        170        180 
KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN ASPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFHNRFDYK DEEFLKLLEK FNENVRILSS PWLQVCNNFP ALIDYLPGSH KTLLKNSDYV 

       250        260        270        280        290        300 
KNFIMEKVKE HQKFLDVNNP RDFIDCFLIK MEQENHLEFT LESLVTTVFD LFGAGTETTS 

       310        320        330        340        350        360 
TTLRYSLLLL LKHPEVADKV QEEIERVIGR HRSPCMQDRS RMPYTDAVIH EIQRFIDLVP 

       370        380        390        400        410        420 
NNLPHTVTRD IKFRNYFIPK GTDIMTSLTS VLHDEKAFPN PKVFDPGHFL DESGNFKKSD 

       430        440        450        460        470        480 
YFMPFSAGKR ICVGEALARM ELFLFLTSIL QNFKLQSLVE PKDLDITAVL NGFVSVPPSF 


QLCFIPV 

« Hide

References

[1]"Sequence and gene expression of rabbit cytochrome P450 IIC16: comparison to highly related family members."
Hassett C., Omiecinski C.J.
Nucleic Acids Res. 18:1429-1434(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Use of a conserved consensus oligomer in the identification of cytochrome P-450 mRNAs."
Hassett C., Omiecinski C.J.
Biochem. Biophys. Res. Commun. 149:326-333(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 414-487.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M29661 mRNA. Translation: AAA31227.1.
M29968 mRNA. Translation: AAA31226.1.
M18376 mRNA. Translation: AAA31215.1.
PIRO4RBC6. S12765.
RefSeqNP_001164593.1. NM_001171122.1.
UniGeneOcu.1855.

3D structure databases

ProteinModelPortalP15123.
SMRP15123. Positions 27-487.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000017976.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSOCUT00000030867; ENSOCUP00000020435; ENSOCUG00000027103.
GeneID100328938.

Organism-specific databases

CTD100328938.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
OrthoDBEOG7RBZ85.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CG_RABIT
AccessionPrimary (citable) accession number: P15123
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: March 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families