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Protein

Cytochrome P450 2C16

Gene

CYP2C16

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi432 – 4321Iron (heme axial ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C16 (EC:1.14.14.1)
Alternative name(s):
CYPIIC16
Gene namesi
Name:CYP2C16
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Cytochrome P450 2C16PRO_0000051706Add
BLAST

Expressioni

Tissue specificityi

Expressed constitutively in liver, lung, testes, and kidney.

Inductioni

By phenobarbital in each tissue with the exception of the kidney.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017976.

Structurei

3D structure databases

ProteinModelPortaliP15123.
SMRiP15123. Positions 27-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP15123.
KOiK07413.
OrthoDBiEOG7RBZ85.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVVVLVLG LCCLLLLSHW KQNSGRGKLP PGPTPFPIIG NILQIDAKDI
60 70 80 90 100
SKSLTKFSER YGPVFTVYLG MKPAVVLHGY QAVKEALVDL GEEFAGRGSF
110 120 130 140 150
PMLDKVSKGL GIVFTNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN ASPCDPTFIL GCAPCNVICS IIFHNRFDYK DEEFLKLLEK
210 220 230 240 250
FNENVRILSS PWLQVCNNFP ALIDYLPGSH KTLLKNSDYV KNFIMEKVKE
260 270 280 290 300
HQKFLDVNNP RDFIDCFLIK MEQENHLEFT LESLVTTVFD LFGAGTETTS
310 320 330 340 350
TTLRYSLLLL LKHPEVADKV QEEIERVIGR HRSPCMQDRS RMPYTDAVIH
360 370 380 390 400
EIQRFIDLVP NNLPHTVTRD IKFRNYFIPK GTDIMTSLTS VLHDEKAFPN
410 420 430 440 450
PKVFDPGHFL DESGNFKKSD YFMPFSAGKR ICVGEALARM ELFLFLTSIL
460 470 480
QNFKLQSLVE PKDLDITAVL NGFVSVPPSF QLCFIPV
Length:487
Mass (Da):55,542
Last modified:April 1, 1990 - v1
Checksum:iF282245DA3CB90A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29661 mRNA. Translation: AAA31227.1.
M29968 mRNA. Translation: AAA31226.1.
M18376 mRNA. Translation: AAA31215.1.
PIRiS12765. O4RBC6.
RefSeqiNP_001164593.1. NM_001171122.1.
UniGeneiOcu.1855.

Genome annotation databases

EnsembliENSOCUT00000030867; ENSOCUP00000020435; ENSOCUG00000027103.
GeneIDi100328938.
KEGGiocu:100328938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29661 mRNA. Translation: AAA31227.1.
M29968 mRNA. Translation: AAA31226.1.
M18376 mRNA. Translation: AAA31215.1.
PIRiS12765. O4RBC6.
RefSeqiNP_001164593.1. NM_001171122.1.
UniGeneiOcu.1855.

3D structure databases

ProteinModelPortaliP15123.
SMRiP15123. Positions 27-487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000017976.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000030867; ENSOCUP00000020435; ENSOCUG00000027103.
GeneIDi100328938.
KEGGiocu:100328938.

Organism-specific databases

CTDi100328938.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP15123.
KOiK07413.
OrthoDBiEOG7RBZ85.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence and gene expression of rabbit cytochrome P450 IIC16: comparison to highly related family members."
    Hassett C., Omiecinski C.J.
    Nucleic Acids Res. 18:1429-1434(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Use of a conserved consensus oligomer in the identification of cytochrome P-450 mRNAs."
    Hassett C., Omiecinski C.J.
    Biochem. Biophys. Res. Commun. 149:326-333(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 414-487.

Entry informationi

Entry nameiCP2CG_RABIT
AccessioniPrimary (citable) accession number: P15123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 29, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.