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P15123

- CP2CG_RABIT

UniProt

P15123 - CP2CG_RABIT

Protein

Cytochrome P450 2C16

Gene

CYP2C16

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi432 – 4321Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C16 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC16
    Gene namesi
    Name:CYP2C16
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Cytochrome P450 2C16PRO_0000051706Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed constitutively in liver, lung, testes, and kidney.

    Inductioni

    By phenobarbital in each tissue with the exception of the kidney.

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000017976.

    Structurei

    3D structure databases

    ProteinModelPortaliP15123.
    SMRiP15123. Positions 27-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    OrthoDBiEOG7RBZ85.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15123-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVVVLVLG LCCLLLLSHW KQNSGRGKLP PGPTPFPIIG NILQIDAKDI    50
    SKSLTKFSER YGPVFTVYLG MKPAVVLHGY QAVKEALVDL GEEFAGRGSF 100
    PMLDKVSKGL GIVFTNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 150
    CLVEELRKTN ASPCDPTFIL GCAPCNVICS IIFHNRFDYK DEEFLKLLEK 200
    FNENVRILSS PWLQVCNNFP ALIDYLPGSH KTLLKNSDYV KNFIMEKVKE 250
    HQKFLDVNNP RDFIDCFLIK MEQENHLEFT LESLVTTVFD LFGAGTETTS 300
    TTLRYSLLLL LKHPEVADKV QEEIERVIGR HRSPCMQDRS RMPYTDAVIH 350
    EIQRFIDLVP NNLPHTVTRD IKFRNYFIPK GTDIMTSLTS VLHDEKAFPN 400
    PKVFDPGHFL DESGNFKKSD YFMPFSAGKR ICVGEALARM ELFLFLTSIL 450
    QNFKLQSLVE PKDLDITAVL NGFVSVPPSF QLCFIPV 487
    Length:487
    Mass (Da):55,542
    Last modified:April 1, 1990 - v1
    Checksum:iF282245DA3CB90A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29661 mRNA. Translation: AAA31227.1.
    M29968 mRNA. Translation: AAA31226.1.
    M18376 mRNA. Translation: AAA31215.1.
    PIRiS12765. O4RBC6.
    RefSeqiNP_001164593.1. NM_001171122.1.
    UniGeneiOcu.1855.

    Genome annotation databases

    EnsembliENSOCUT00000030867; ENSOCUP00000020435; ENSOCUG00000027103.
    GeneIDi100328938.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29661 mRNA. Translation: AAA31227.1 .
    M29968 mRNA. Translation: AAA31226.1 .
    M18376 mRNA. Translation: AAA31215.1 .
    PIRi S12765. O4RBC6.
    RefSeqi NP_001164593.1. NM_001171122.1.
    UniGenei Ocu.1855.

    3D structure databases

    ProteinModelPortali P15123.
    SMRi P15123. Positions 27-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000017976.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSOCUT00000030867 ; ENSOCUP00000020435 ; ENSOCUG00000027103 .
    GeneIDi 100328938.

    Organism-specific databases

    CTDi 100328938.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    OrthoDBi EOG7RBZ85.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and gene expression of rabbit cytochrome P450 IIC16: comparison to highly related family members."
      Hassett C., Omiecinski C.J.
      Nucleic Acids Res. 18:1429-1434(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Use of a conserved consensus oligomer in the identification of cytochrome P-450 mRNAs."
      Hassett C., Omiecinski C.J.
      Biochem. Biophys. Res. Commun. 149:326-333(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 414-487.

    Entry informationi

    Entry nameiCP2CG_RABIT
    AccessioniPrimary (citable) accession number: P15123
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3