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P15120

- UROK_CHICK

UniProt

P15120 - UROK_CHICK

Protein

Urokinase-type plasminogen activator

Gene

PLAU

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

    Catalytic activityi

    Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei217 – 2171Charge relay systemBy similarity
    Active sitei272 – 2721Charge relay systemBy similarity
    Active sitei373 – 3731Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Plasminogen activation

    Protein family/group databases

    MEROPSiS01.231.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urokinase-type plasminogen activator (EC:3.4.21.73)
    Short name:
    U-plasminogen activator
    Short name:
    uPA
    Cleaved into the following 2 chains:
    Gene namesi
    Name:PLAU
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 434414Urokinase-type plasminogen activatorPRO_0000028337Add
    BLAST
    Chaini21 – 171151Urokinase-type plasminogen activator chain ABy similarityPRO_0000028338Add
    BLAST
    Chaini173 – 434262Urokinase-type plasminogen activator chain BBy similarityPRO_0000028339Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 48By similarity
    Disulfide bondi42 ↔ 60By similarity
    Disulfide bondi62 ↔ 71By similarity
    Disulfide bondi79 ↔ 158By similarity
    Disulfide bondi96 ↔ 139By similarity
    Disulfide bondi128 ↔ 152By similarity
    Disulfide bondi162 ↔ 296Interchain (between A and B chains)PROSITE-ProRule annotation
    Disulfide bondi202 ↔ 218By similarity
    Disulfide bondi210 ↔ 285By similarity
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi310 ↔ 379By similarity
    Disulfide bondi342 ↔ 358By similarity
    Disulfide bondi369 ↔ 397By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000008143.

    Structurei

    3D structure databases

    ProteinModelPortaliP15120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 7237EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini79 – 15880KringlePROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 421249Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni159 – 17214Connecting peptideAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 kringle domain.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Kringle, Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000237314.
    HOVERGENiHBG008633.
    InParanoidiP15120.
    KOiK01348.
    PhylomeDBiP15120.

    Family and domain databases

    Gene3Di2.40.20.10. 1 hit.
    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00051. Kringle. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00181. EGF. 1 hit.
    SM00130. KR. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15120-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLIIFLTVT LCTLVTGLDS VYIRQYYKLS HKHRPQHREC QCLNGGTCIT    50
    YRFFSQIKRC LCPEGYGGLH CEIDTNSICY SGNGEDYRGM AEDPGCLYWD 100
    HPSVIRWGDY HADLKNALQL GLGKHNYCRN PNGRSRPWCY TKRRYSIQET 150
    PCSTIEKCER TCGQRSFSKY FKIVGGSQAE VETQPWIAGI FQNIMGTDQF 200
    LCGGSLIDPC WVLTAAHCFY NPTKKQPNKS VYKVFLGKSI LNTNDEHEQV 250
    FMVDEIISHP DFTDHTGGND NDIALIRIRT ASGQCAVESN YVRTVCLPEK 300
    NLNLYDNTWC EIAGYGKQNS YDIYYAQRLM SATVNLISQD DCKNKYYDST 350
    RVTDNMVCAG DPLWETDACK GDSGGPMVCE HNGRMTLYGI VSWGDGCAKK 400
    NKPGVYTRVT RYLNWIDSNM NAVFTKSRSF REPK 434
    Length:434
    Mass (Da):49,400
    Last modified:April 1, 1990 - v1
    Checksum:iBD881048DD666A55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05187 mRNA. Translation: AAA49131.1.
    J05188 Genomic DNA. Translation: AAA49130.1.
    PIRiA35005.
    RefSeqiNP_990774.2. NM_205443.2.
    UniGeneiGga.817.

    Genome annotation databases

    GeneIDi396424.
    KEGGigga:396424.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05187 mRNA. Translation: AAA49131.1 .
    J05188 Genomic DNA. Translation: AAA49130.1 .
    PIRi A35005.
    RefSeqi NP_990774.2. NM_205443.2.
    UniGenei Gga.817.

    3D structure databases

    ProteinModelPortali P15120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000008143.

    Protein family/group databases

    MEROPSi S01.231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396424.
    KEGGi gga:396424.

    Organism-specific databases

    CTDi 5328.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000237314.
    HOVERGENi HBG008633.
    InParanoidi P15120.
    KOi K01348.
    PhylomeDBi P15120.

    Miscellaneous databases

    NextBioi 20816465.
    PROi P15120.

    Family and domain databases

    Gene3Di 2.40.20.10. 1 hit.
    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00051. Kringle. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00181. EGF. 1 hit.
    SM00130. KR. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The chicken urokinase-type plasminogen activator gene."
      Leslie N.D., Kessler C.A., Bell S.M., Degen J.L.
      J. Biol. Chem. 265:1339-1344(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiUROK_CHICK
    AccessioniPrimary (citable) accession number: P15120
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3