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P15120

- UROK_CHICK

UniProt

P15120 - UROK_CHICK

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Protein

Urokinase-type plasminogen activator

Gene

PLAU

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Catalytic activityi

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171Charge relay systemBy similarity
Active sitei272 – 2721Charge relay systemBy similarity
Active sitei373 – 3731Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Plasminogen activation

Protein family/group databases

MEROPSiS01.231.

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase-type plasminogen activator (EC:3.4.21.73)
Short name:
U-plasminogen activator
Short name:
uPA
Cleaved into the following 2 chains:
Gene namesi
Name:PLAU
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 434414Urokinase-type plasminogen activatorPRO_0000028337Add
BLAST
Chaini21 – 171151Urokinase-type plasminogen activator chain ABy similarityPRO_0000028338Add
BLAST
Chaini173 – 434262Urokinase-type plasminogen activator chain BBy similarityPRO_0000028339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 48By similarity
Disulfide bondi42 ↔ 60By similarity
Disulfide bondi62 ↔ 71By similarity
Disulfide bondi79 ↔ 158By similarity
Disulfide bondi96 ↔ 139By similarity
Disulfide bondi128 ↔ 152By similarity
Disulfide bondi162 ↔ 296Interchain (between A and B chains)PROSITE-ProRule annotation
Disulfide bondi202 ↔ 218By similarity
Disulfide bondi210 ↔ 285By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi310 ↔ 379By similarity
Disulfide bondi342 ↔ 358By similarity
Disulfide bondi369 ↔ 397By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008143.

Structurei

3D structure databases

ProteinModelPortaliP15120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 7237EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini79 – 15880KringlePROSITE-ProRule annotationAdd
BLAST
Domaini173 – 421249Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 17214Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 kringle domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Kringle, Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000237314.
HOVERGENiHBG008633.
InParanoidiP15120.
KOiK01348.
PhylomeDBiP15120.

Family and domain databases

Gene3Di2.40.20.10. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00181. EGF. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15120-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLIIFLTVT LCTLVTGLDS VYIRQYYKLS HKHRPQHREC QCLNGGTCIT
60 70 80 90 100
YRFFSQIKRC LCPEGYGGLH CEIDTNSICY SGNGEDYRGM AEDPGCLYWD
110 120 130 140 150
HPSVIRWGDY HADLKNALQL GLGKHNYCRN PNGRSRPWCY TKRRYSIQET
160 170 180 190 200
PCSTIEKCER TCGQRSFSKY FKIVGGSQAE VETQPWIAGI FQNIMGTDQF
210 220 230 240 250
LCGGSLIDPC WVLTAAHCFY NPTKKQPNKS VYKVFLGKSI LNTNDEHEQV
260 270 280 290 300
FMVDEIISHP DFTDHTGGND NDIALIRIRT ASGQCAVESN YVRTVCLPEK
310 320 330 340 350
NLNLYDNTWC EIAGYGKQNS YDIYYAQRLM SATVNLISQD DCKNKYYDST
360 370 380 390 400
RVTDNMVCAG DPLWETDACK GDSGGPMVCE HNGRMTLYGI VSWGDGCAKK
410 420 430
NKPGVYTRVT RYLNWIDSNM NAVFTKSRSF REPK
Length:434
Mass (Da):49,400
Last modified:April 1, 1990 - v1
Checksum:iBD881048DD666A55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05187 mRNA. Translation: AAA49131.1.
J05188 Genomic DNA. Translation: AAA49130.1.
PIRiA35005.
RefSeqiNP_990774.2. NM_205443.2.
UniGeneiGga.817.

Genome annotation databases

GeneIDi396424.
KEGGigga:396424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05187 mRNA. Translation: AAA49131.1 .
J05188 Genomic DNA. Translation: AAA49130.1 .
PIRi A35005.
RefSeqi NP_990774.2. NM_205443.2.
UniGenei Gga.817.

3D structure databases

ProteinModelPortali P15120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000008143.

Protein family/group databases

MEROPSi S01.231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396424.
KEGGi gga:396424.

Organism-specific databases

CTDi 5328.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000237314.
HOVERGENi HBG008633.
InParanoidi P15120.
KOi K01348.
PhylomeDBi P15120.

Miscellaneous databases

NextBioi 20816465.
PROi P15120.

Family and domain databases

Gene3Di 2.40.20.10. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00181. EGF. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The chicken urokinase-type plasminogen activator gene."
    Leslie N.D., Kessler C.A., Bell S.M., Degen J.L.
    J. Biol. Chem. 265:1339-1344(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiUROK_CHICK
AccessioniPrimary (citable) accession number: P15120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3