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P15120

- UROK_CHICK

UniProt

P15120 - UROK_CHICK

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Protein

Urokinase-type plasminogen activator

Gene
PLAU
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Catalytic activityi

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171Charge relay system By similarity
Active sitei272 – 2721Charge relay system By similarity
Active sitei373 – 3731Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Plasminogen activation

Protein family/group databases

MEROPSiS01.231.

Names & Taxonomyi

Protein namesi
Recommended name:
Urokinase-type plasminogen activator (EC:3.4.21.73)
Short name:
U-plasminogen activator
Short name:
uPA
Cleaved into the following 2 chains:
Gene namesi
Name:PLAU
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 434414Urokinase-type plasminogen activatorPRO_0000028337Add
BLAST
Chaini21 – 171151Urokinase-type plasminogen activator chain A By similarityPRO_0000028338Add
BLAST
Chaini173 – 434262Urokinase-type plasminogen activator chain B By similarityPRO_0000028339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 48 By similarity
Disulfide bondi42 ↔ 60 By similarity
Disulfide bondi62 ↔ 71 By similarity
Disulfide bondi79 ↔ 158 By similarity
Disulfide bondi96 ↔ 139 By similarity
Disulfide bondi128 ↔ 152 By similarity
Disulfide bondi162 ↔ 296Interchain (between A and B chains) By similarity
Disulfide bondi202 ↔ 218 By similarity
Disulfide bondi210 ↔ 285 By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi310 ↔ 379 By similarity
Disulfide bondi342 ↔ 358 By similarity
Disulfide bondi369 ↔ 397 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008143.

Structurei

3D structure databases

ProteinModelPortaliP15120.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 7237EGF-likeAdd
BLAST
Domaini79 – 15880KringleAdd
BLAST
Domaini173 – 421249Peptidase S1Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 17214Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.
Contains 1 EGF-like domain.
Contains 1 kringle domain.

Keywords - Domaini

EGF-like domain, Kringle, Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000237314.
HOVERGENiHBG008633.
InParanoidiP15120.
KOiK01348.
PhylomeDBiP15120.

Family and domain databases

Gene3Di2.40.20.10. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00181. EGF. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15120-1 [UniParc]FASTAAdd to Basket

« Hide

MKLIIFLTVT LCTLVTGLDS VYIRQYYKLS HKHRPQHREC QCLNGGTCIT    50
YRFFSQIKRC LCPEGYGGLH CEIDTNSICY SGNGEDYRGM AEDPGCLYWD 100
HPSVIRWGDY HADLKNALQL GLGKHNYCRN PNGRSRPWCY TKRRYSIQET 150
PCSTIEKCER TCGQRSFSKY FKIVGGSQAE VETQPWIAGI FQNIMGTDQF 200
LCGGSLIDPC WVLTAAHCFY NPTKKQPNKS VYKVFLGKSI LNTNDEHEQV 250
FMVDEIISHP DFTDHTGGND NDIALIRIRT ASGQCAVESN YVRTVCLPEK 300
NLNLYDNTWC EIAGYGKQNS YDIYYAQRLM SATVNLISQD DCKNKYYDST 350
RVTDNMVCAG DPLWETDACK GDSGGPMVCE HNGRMTLYGI VSWGDGCAKK 400
NKPGVYTRVT RYLNWIDSNM NAVFTKSRSF REPK 434
Length:434
Mass (Da):49,400
Last modified:April 1, 1990 - v1
Checksum:iBD881048DD666A55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05187 mRNA. Translation: AAA49131.1.
J05188 Genomic DNA. Translation: AAA49130.1.
PIRiA35005.
RefSeqiNP_990774.2. NM_205443.2.
UniGeneiGga.817.

Genome annotation databases

GeneIDi396424.
KEGGigga:396424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05187 mRNA. Translation: AAA49131.1 .
J05188 Genomic DNA. Translation: AAA49130.1 .
PIRi A35005.
RefSeqi NP_990774.2. NM_205443.2.
UniGenei Gga.817.

3D structure databases

ProteinModelPortali P15120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000008143.

Protein family/group databases

MEROPSi S01.231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396424.
KEGGi gga:396424.

Organism-specific databases

CTDi 5328.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000237314.
HOVERGENi HBG008633.
InParanoidi P15120.
KOi K01348.
PhylomeDBi P15120.

Miscellaneous databases

NextBioi 20816465.
PROi P15120.

Family and domain databases

Gene3Di 2.40.20.10. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00181. EGF. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The chicken urokinase-type plasminogen activator gene."
    Leslie N.D., Kessler C.A., Bell S.M., Degen J.L.
    J. Biol. Chem. 265:1339-1344(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiUROK_CHICK
AccessioniPrimary (citable) accession number: P15120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 14, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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