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P15119 (MCPT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mast cell protease 2

Short name=mMCP-2
EC=3.4.21.-
Gene names
Name:Mcpt2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Mucosal mast cells.

Sequence similarities

Belongs to the peptidase S1 family. Granzyme subfamily.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Propeptide19 – 202Activation peptide
PRO_0000027451
Chain21 – 244224Mast cell protease 2
PRO_0000027452

Regions

Domain21 – 242222Peptidase S1

Sites

Active site651Charge relay system By similarity
Active site1091Charge relay system By similarity
Active site2021Charge relay system By similarity

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential
Disulfide bond50 ↔ 66 By similarity
Disulfide bond143 ↔ 208 By similarity
Disulfide bond174 ↔ 187 By similarity

Experimental info

Sequence conflict671N → R in AAA39972. Ref.1
Sequence conflict1081Y → N in AAA39972. Ref.1
Sequence conflict1781S → N in AAA39972. Ref.1
Sequence conflict1941S → L in AAA39972. Ref.1
Sequence conflict2101S → G in AAA39972. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P15119 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 132E248B6E2339CC

FASTA24426,732
        10         20         30         40         50         60 
MQALLFLMAL LLPSGAGAEE IIGGVEAKPH SRPYMAYLKF TTKNGSKERC GGFLIAPQFV 

        70         80         90        100        110        120 
MTAAHCNGSE ISVILGAHNI NKNEPTQQII KTEKTFVHPK FQYLSGFYDI MLLKLQKKAE 

       130        140        150        160        170        180 
LNSDVDVISL PSSSDFIKPG KMCWTAGWGK TGKNNPLSVT LREVELRIMD QEACKDHSDY 

       190        200        210        220        230        240 
DYQLQVCAGS PTTSKSIGQG DSGGPLVCDS VAHGIASSYE AKAPAVFTRI SYYLPWIYKV 


LKSK 

« Hide

References

[1]"Identification and molecular cloning of a novel mouse mucosal mast cell serine protease."
Serafin W.E., Reynolds D.S., Rogelj S., Lane W.S., Conder G.A., Johnson S.S., Austen K.F., Stevens R.L.
J. Biol. Chem. 265:423-429(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14."
Gurish M.F., Nadeau J.H., Johnson K.R., McNeil H.P., Grattan K.M., Austen K.F., Stevens R.L.
J. Biol. Chem. 268:11372-11379(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Hematopoietic.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05177 mRNA. Translation: AAA39972.1.
L08486 Genomic DNA. Translation: AAA74555.1.
CCDSCCDS27139.1.
PIRA34910.
A46721.
RefSeqNP_032597.1. NM_008571.1.
UniGeneMm.4409.

3D structure databases

ProteinModelPortalP15119.
SMRP15119. Positions 21-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000015576.

Protein family/group databases

MEROPSS01.003.

Proteomic databases

MaxQBP15119.
PRIDEP15119.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015576; ENSMUSP00000015576; ENSMUSG00000022226.
GeneID17225.
KEGGmmu:17225.
UCSCuc007ubk.1. mouse.

Organism-specific databases

CTD17225.
MGIMGI:96938. Mcpt2.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP15119.
KOK08662.
OMAKLPRANE.
OrthoDBEOG7RRF7Z.
PhylomeDBP15119.
TreeFamTF333630.

Gene expression databases

BgeeP15119.
CleanExMM_MCPT2.
GenevestigatorP15119.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291640.
PROP15119.
SOURCESearch...

Entry information

Entry nameMCPT2_MOUSE
AccessionPrimary (citable) accession number: P15119
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot