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P15119

- MCPT2_MOUSE

UniProt

P15119 - MCPT2_MOUSE

Protein

Mast cell protease 2

Gene

Mcpt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei109 – 1091Charge relay systemBy similarity
    Active sitei202 – 2021Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mast cell protease 2 (EC:3.4.21.-)
    Short name:
    mMCP-2
    Gene namesi
    Name:Mcpt2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:96938. Mcpt2.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: MGI
    2. secretory granule Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Propeptidei19 – 202Activation peptidePRO_0000027451
    Chaini21 – 244224Mast cell protease 2PRO_0000027452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
    Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP15119.
    PRIDEiP15119.

    Expressioni

    Tissue specificityi

    Mucosal mast cells.

    Gene expression databases

    BgeeiP15119.
    CleanExiMM_MCPT2.
    GenevestigatoriP15119.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000015576.

    Structurei

    3D structure databases

    ProteinModelPortaliP15119.
    SMRiP15119. Positions 21-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 242222Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP15119.
    KOiK08662.
    OMAiKLPRANE.
    OrthoDBiEOG7RRF7Z.
    PhylomeDBiP15119.
    TreeFamiTF333630.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15119-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQALLFLMAL LLPSGAGAEE IIGGVEAKPH SRPYMAYLKF TTKNGSKERC    50
    GGFLIAPQFV MTAAHCNGSE ISVILGAHNI NKNEPTQQII KTEKTFVHPK 100
    FQYLSGFYDI MLLKLQKKAE LNSDVDVISL PSSSDFIKPG KMCWTAGWGK 150
    TGKNNPLSVT LREVELRIMD QEACKDHSDY DYQLQVCAGS PTTSKSIGQG 200
    DSGGPLVCDS VAHGIASSYE AKAPAVFTRI SYYLPWIYKV LKSK 244
    Length:244
    Mass (Da):26,732
    Last modified:October 1, 1996 - v2
    Checksum:i132E248B6E2339CC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671N → R in AAA39972. (PubMed:1688433)Curated
    Sequence conflicti108 – 1081Y → N in AAA39972. (PubMed:1688433)Curated
    Sequence conflicti178 – 1781S → N in AAA39972. (PubMed:1688433)Curated
    Sequence conflicti194 – 1941S → L in AAA39972. (PubMed:1688433)Curated
    Sequence conflicti210 – 2101S → G in AAA39972. (PubMed:1688433)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05177 mRNA. Translation: AAA39972.1.
    L08486 Genomic DNA. Translation: AAA74555.1.
    CCDSiCCDS27139.1.
    PIRiA34910.
    A46721.
    RefSeqiNP_032597.1. NM_008571.1.
    UniGeneiMm.4409.

    Genome annotation databases

    EnsembliENSMUST00000015576; ENSMUSP00000015576; ENSMUSG00000022226.
    GeneIDi17225.
    KEGGimmu:17225.
    UCSCiuc007ubk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05177 mRNA. Translation: AAA39972.1 .
    L08486 Genomic DNA. Translation: AAA74555.1 .
    CCDSi CCDS27139.1.
    PIRi A34910.
    A46721.
    RefSeqi NP_032597.1. NM_008571.1.
    UniGenei Mm.4409.

    3D structure databases

    ProteinModelPortali P15119.
    SMRi P15119. Positions 21-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000015576.

    Protein family/group databases

    MEROPSi S01.003.

    Proteomic databases

    MaxQBi P15119.
    PRIDEi P15119.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015576 ; ENSMUSP00000015576 ; ENSMUSG00000022226 .
    GeneIDi 17225.
    KEGGi mmu:17225.
    UCSCi uc007ubk.1. mouse.

    Organism-specific databases

    CTDi 17225.
    MGIi MGI:96938. Mcpt2.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P15119.
    KOi K08662.
    OMAi KLPRANE.
    OrthoDBi EOG7RRF7Z.
    PhylomeDBi P15119.
    TreeFami TF333630.

    Miscellaneous databases

    NextBioi 291640.
    PROi P15119.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15119.
    CleanExi MM_MCPT2.
    Genevestigatori P15119.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular cloning of a novel mouse mucosal mast cell serine protease."
      Serafin W.E., Reynolds D.S., Rogelj S., Lane W.S., Conder G.A., Johnson S.S., Austen K.F., Stevens R.L.
      J. Biol. Chem. 265:423-429(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14."
      Gurish M.F., Nadeau J.H., Johnson K.R., McNeil H.P., Grattan K.M., Austen K.F., Stevens R.L.
      J. Biol. Chem. 268:11372-11379(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Hematopoietic.

    Entry informationi

    Entry nameiMCPT2_MOUSE
    AccessioniPrimary (citable) accession number: P15119
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3