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P15116

- CADH2_MOUSE

UniProt

P15116 - CADH2_MOUSE

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Protein
Cadherin-2
Gene
Cdh2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi262 – 2621Calcium 1
Metal bindingi262 – 2621Calcium 2
Metal bindingi293 – 2931Calcium 3

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: IntAct
  3. protein phosphatase binding Source: UniProtKB

GO - Biological processi

  1. blood vessel morphogenesis Source: MGI
  2. calcium-dependent cell-cell adhesion Source: MGI
  3. cell adhesion Source: MGI
  4. cell migration Source: MGI
  5. heterophilic cell-cell adhesion Source: MGI
  6. homophilic cell adhesion Source: MGI
  7. negative regulation of canonical Wnt signaling pathway Source: MGI
  8. positive regulation of MAPK cascade Source: MGI
  9. striated muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-2
Alternative name(s):
Neural cadherin
Short name:
N-cadherin
CD_antigen: CD325
Gene namesi
Name:Cdh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:88355. Cdh2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini160 – 724565Extracellular Reviewed prediction
Add
BLAST
Transmembranei725 – 74521Helical; Reviewed prediction
Add
BLAST
Topological domaini746 – 906161Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. adherens junction Source: MGI
  2. apical plasma membrane Source: MGI
  3. catenin complex Source: Ensembl
  4. cell-cell junction Source: MGI
  5. fascia adherens Source: MGI
  6. integral component of membrane Source: UniProtKB-KW
  7. intercalated disc Source: BHF-UCL
  8. lamellipodium Source: MGI
  9. membrane Source: MGI
  10. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi262 – 2621D → A: Abolishes dimerization. 1 Publication
Mutagenesisi293 – 2931D → A: Severely impaired the binding of calcium to all three sites. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 159134 Reviewed prediction
PRO_0000003733Add
BLAST
Chaini160 – 906747Cadherin-2
PRO_0000003734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi273 – 2731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi651 – 6511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi692 – 6921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP15116.
PaxDbiP15116.
PRIDEiP15116.

PTM databases

PhosphoSiteiP15116.

Expressioni

Developmental stagei

Expressed at all stages of testicular development with highest levels found in testes of 21-day-old mice.1 Publication

Gene expression databases

ArrayExpressiP15116.
BgeeiP15116.
CleanExiMM_CDH2.
GenevestigatoriP15116.

Interactioni

Subunit structurei

Interacts with CDCP1 By similarity. Interacts with PCDH8; this complex may also include TAOK2 By similarity. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN1P180313EBI-397974,EBI-968788From a different organism.

Protein-protein interaction databases

BioGridi198637. 20 interactions.
DIPiDIP-31564N.
IntActiP15116. 9 interactions.
MINTiMINT-4089694.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi40 – 434
Beta strandi55 – 573
Beta strandi69 – 724
Beta strandi76 – 827
Turni83 – 853
Beta strandi86 – 916
Beta strandi96 – 983
Beta strandi100 – 1089
Turni109 – 1124
Beta strandi113 – 1219
Beta strandi166 – 1716
Beta strandi176 – 1827
Helixi186 – 1905
Beta strandi194 – 1996
Turni200 – 2023
Beta strandi203 – 2064
Beta strandi209 – 2124
Turni214 – 2163
Beta strandi218 – 2214
Turni227 – 2293
Beta strandi232 – 2409
Turni242 – 2443
Beta strandi246 – 2483
Beta strandi251 – 2588
Beta strandi268 – 2769
Beta strandi285 – 2884
Turni300 – 3023
Beta strandi307 – 3104
Beta strandi321 – 3233
Turni325 – 3273
Beta strandi329 – 3324
Turni339 – 3413
Beta strandi343 – 3508
Turni353 – 3564
Turni358 – 3603
Beta strandi365 – 3728
Beta strandi381 – 39414
Beta strandi396 – 40611
Turni414 – 4163
Beta strandi421 – 4255
Beta strandi431 – 4355
Turni437 – 4393
Beta strandi441 – 4466
Turni452 – 4543
Beta strandi456 – 4638
Beta strandi466 – 4683
Helixi478 – 4803
Beta strandi481 – 4899
Beta strandi496 – 50813
Beta strandi515 – 5184
Beta strandi526 – 5283
Beta strandi532 – 5387
Beta strandi544 – 5463
Turni548 – 5503
Beta strandi552 – 5576
Beta strandi561 – 5633
Beta strandi568 – 57912
Beta strandi581 – 5833
Beta strandi586 – 59611
Beta strandi604 – 6063
Beta strandi621 – 6233
Beta strandi633 – 6364
Beta strandi638 – 6403
Beta strandi643 – 6453
Helixi646 – 6516
Beta strandi652 – 6565
Beta strandi658 – 6603
Beta strandi662 – 6665
Beta strandi674 – 68310
Beta strandi685 – 6884
Beta strandi691 – 70010

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NCGX-ray2.10A160-267[»]
1NCHX-ray2.10A/B160-267[»]
1NCIX-ray2.10A/B160-267[»]
1NCJX-ray3.40A160-374[»]
1OP4NMR-A24-159[»]
2QVIX-ray3.01A160-374[»]
3Q2WX-ray3.20A160-712[»]
ProteinModelPortaliP15116.
SMRiP15116. Positions 24-701, 818-904.

Miscellaneous databases

EvolutionaryTraceiP15116.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 267108Cadherin 1
Add
BLAST
Domaini268 – 382115Cadherin 2
Add
BLAST
Domaini383 – 497115Cadherin 3
Add
BLAST
Domaini498 – 603106Cadherin 4
Add
BLAST
Domaini604 – 717114Cadherin 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi863 – 87816Ser-rich
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251747.
GeneTreeiENSGT00740000115112.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiQ6GU11.
KOiK06736.
OMAiHSGHLQR.
OrthoDBiEOG7RJPQM.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15116-1 [UniParc]FASTAAdd to Basket

« Hide

MCRIAGAPRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLPKDVH    50
EGQPLLNVKF SNCNRKRKVQ YESSEPADFK VDEDGTVYAV RSFPLTAEQA 100
KFLIYAQDKE TQEKWQVAVN LSREPTLTEE PMKEPHEIEE IVFPRQLAKH 150
SGALQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP 200
GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV DINGNQVENP 250
IDIVINVIDM NDNRPEFLHQ VWNGSVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ 350
ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV 400
ANLTVTDKDQ PHTPAWNAAY RISGGDPTGR FAILTDPNSN DGLVTVVKPI 450
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN 500
PKIIRQEEGL HAGTMLTTLT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN 550
GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPEPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR 650
NWTINRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV 700
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD 750
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA 800
IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP 850
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG DQDYDYLNDW GPRFKKLADM 900
YGGGDD 906
Length:906
Mass (Da):99,796
Last modified:July 27, 2011 - v2
Checksum:iBDAB8063A23E1F13
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 93APR → GRG in AAA37353. 1 Publication
Sequence conflicti565 – 5673NVK → YVQ in AAA37353. 1 Publication
Sequence conflicti624 – 6241T → A in AAA37353. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31131 mRNA. Translation: AAA37353.1.
AB008811 mRNA. Translation: BAA23549.1.
S45011 Genomic DNA. Translation: AAB23356.1.
CH466557 Genomic DNA. Translation: EDK96930.1.
BC022107 mRNA. Translation: AAH22107.1.
CCDSiCCDS29076.1.
PIRiA32759. IJMSCN.
RefSeqiNP_031690.3. NM_007664.4.
UniGeneiMm.257437.

Genome annotation databases

EnsembliENSMUST00000025166; ENSMUSP00000025166; ENSMUSG00000024304.
GeneIDi12558.
KEGGimmu:12558.
UCSCiuc008edx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31131 mRNA. Translation: AAA37353.1 .
AB008811 mRNA. Translation: BAA23549.1 .
S45011 Genomic DNA. Translation: AAB23356.1 .
CH466557 Genomic DNA. Translation: EDK96930.1 .
BC022107 mRNA. Translation: AAH22107.1 .
CCDSi CCDS29076.1.
PIRi A32759. IJMSCN.
RefSeqi NP_031690.3. NM_007664.4.
UniGenei Mm.257437.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NCG X-ray 2.10 A 160-267 [» ]
1NCH X-ray 2.10 A/B 160-267 [» ]
1NCI X-ray 2.10 A/B 160-267 [» ]
1NCJ X-ray 3.40 A 160-374 [» ]
1OP4 NMR - A 24-159 [» ]
2QVI X-ray 3.01 A 160-374 [» ]
3Q2W X-ray 3.20 A 160-712 [» ]
ProteinModelPortali P15116.
SMRi P15116. Positions 24-701, 818-904.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198637. 20 interactions.
DIPi DIP-31564N.
IntActi P15116. 9 interactions.
MINTi MINT-4089694.

PTM databases

PhosphoSitei P15116.

Proteomic databases

MaxQBi P15116.
PaxDbi P15116.
PRIDEi P15116.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025166 ; ENSMUSP00000025166 ; ENSMUSG00000024304 .
GeneIDi 12558.
KEGGi mmu:12558.
UCSCi uc008edx.2. mouse.

Organism-specific databases

CTDi 1000.
MGIi MGI:88355. Cdh2.

Phylogenomic databases

eggNOGi NOG251747.
GeneTreei ENSGT00740000115112.
HOGENOMi HOG000231254.
HOVERGENi HBG106438.
InParanoidi Q6GU11.
KOi K06736.
OMAi HSGHLQR.
OrthoDBi EOG7RJPQM.
TreeFami TF316817.

Miscellaneous databases

EvolutionaryTracei P15116.
NextBioi 281622.
PROi P15116.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15116.
Bgeei P15116.
CleanExi MM_CDH2.
Genevestigatori P15116.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTi SM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Tamura K.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Genomic structure and chromosomal mapping of the mouse N-cadherin gene."
    Miyatani S., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeichi M.
    Proc. Natl. Acad. Sci. U.S.A. 89:8443-8447(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  6. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
    Munro S.B., Blaschuk O.W.
    Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Testis.
  7. "N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling."
    Cavallaro U., Niedermeyer J., Fuxa M., Christofori G.
    Nat. Cell Biol. 3:650-657(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH FGFR4; PLCG1; FRS2; SRC; GAP43 AND CTTN.
  8. "Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases."
    Yasuda S., Tanaka H., Sugiura H., Okamura K., Sakaguchi T., Tran U., Takemiya T., Mizoguchi A., Yagita Y., Sakurai T., De Robertis E.M., Yamagata K.
    Neuron 56:456-471(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PCDH8-MEDIATED ENDOCYTOSIS.
  9. "Sequential binding of calcium leads to dimerization in neural cadherin."
    Vunnam N., Pedigo S.
    Biochemistry 50:2973-2982(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: CALCIUM-BINDING SITES, MUTAGENESIS OF ASP-262 AND ASP-293.
  10. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 160-267.
  11. "Structure-function analysis of cell adhesion by neural (N-) cadherin."
    Tamura K., Shan W.S., Hendrickson W.A., Colman D.R., Shapiro L.
    Neuron 20:1153-1163(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 160-374.

Entry informationi

Entry nameiCADH2_MOUSE
AccessioniPrimary (citable) accession number: P15116
Secondary accession number(s): Q64260, Q6GU11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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