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Reviewed, UniProtKB/Swiss-Prot P15116 (CADH2_MOUSE)

Last modified January 19, 2010. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cadherin-2
Alternative name(s):
    Neural cadherin
      Short name=N-cadherin
    CD_antigen=CD325
Gene names
Name: Cdh2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length906 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.

Subunit structure

Interacts with CDCP1 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Developmental stage

Expressed at all stages of testicular development with highest levels found in testes of 21-day-old mice. Ref.4

Sequence similarities

Contains 5 cadherin domains.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

PTPN1P180313EBI-397974,EBI-968788From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 159134 Potential
PRO_0000003733
Chain160 – 906747Cadherin-2
PRO_0000003734

Regions

Topological domain160 – 724565Extracellular Potential
Transmembrane725 – 74521 Potential
Topological domain746 – 906161Cytoplasmic Potential
Domain160 – 267108Cadherin 1
Domain268 – 382115Cadherin 2
Domain383 – 497115Cadherin 3
Domain498 – 603106Cadherin 4
Domain604 – 717114Cadherin 5
Compositional bias863 – 87816Ser-rich

Amino acid modifications

Modified residue7851Phosphotyrosine By similarity
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation5721N-linked (GlcNAc...) Potential
Glycosylation6511N-linked (GlcNAc...) Potential
Glycosylation6921N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict7 – 93GRG → APR in BAA23549. Ref.2
Sequence conflict565 – 5673YVQ → NVK in BAA23549. Ref.2
Sequence conflict6241A → T in BAA23549. Ref.2

Secondary structure

1 .......................................................... 906
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P15116-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 0206741B771707B7

FASTA90699,761
        10         20         30         40         50         60 
MCRIAGGRGT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLPKDVH EGQPLLNVKF 

        70         80         90        100        110        120 
SNCNRKRKVQ YESSEPADFK VDEDGTVYAV RSFPLTAEQA KFLIYAQDKE TQEKWQVAVN 

       130        140        150        160        170        180 
LSREPTLTEE PMKEPHEIEE IVFPRQLAKH SGALQRQKRD WVIPPINLPE NSRGPFPQEL 

       190        200        210        220        230        240 
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 

       250        260        270        280        290        300 
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGSVPEGS KPGTYVMTVT AIDADDPNAL 

       310        320        330        340        350        360 
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 

       370        380        390        400        410        420 
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAAY 

       430        440        450        460        470        480 
RISGGDPTGR FAILTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 

       490        500        510        520        530        540 
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTLT AQDPDRYMQQ NIRYTKLSDP 

       550        560        570        580        590        600 
ANWLKIDPVN GQITTIAVLD RESPYVQNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 

       610        620        630        640        650        660 
NAPQVLPQEA ETCETPEPNS INIAALDYDI DPNAGPFAFD LPLSPVTIKR NWTINRLNGD 

       670        680        690        700        710        720 
FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 

       730        740        750        760        770        780 
GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 

       790        800        810        820        830        840 
EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 

       850        860        870        880        890        900 
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG DQDYDYLNDW GPRFKKLADM 


YGGGDD

« Hide

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References

[1]"Neural cadherin: role in selective cell-cell adhesion."
Miyatani S., Shimamura K., Hatta M., Nagafuchi A., Nose A., Matsunaga M., Hatta K., Takeichi M.
Science 245:631-635(1989) [PubMed: 2762814] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Tamura K.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Genomic structure and chromosomal mapping of the mouse N-cadherin gene."
Miyatani S., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeichi M.
Proc. Natl. Acad. Sci. U.S.A. 89:8443-8447(1992) [PubMed: 1528849] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
[4]"A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
Munro S.B., Blaschuk O.W.
Biol. Reprod. 55:822-827(1996) [PubMed: 8879495] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
Strain: C57BL/6.
Tissue: Testis.
[5]"Structural basis of cell-cell adhesion by cadherins."
Shapiro L., Fannon A.M., Kwong P.D., Thompson A., Lehmann M.S., Gruebel G., Legrand J.-F., Als-Nielsen J., Colman D.R., Hendrickson W.A.
Nature 374:327-337(1995) [PubMed: 7885471] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 160-267.
[6]"Structure-function analysis of cell adhesion by neural (N-) cadherin."
Tamura K., Shan W.S., Hendrickson W.A., Colman D.R., Shapiro L.
Neuron 20:1153-1163(1998) [PubMed: 9655503] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 160-374.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M31131 mRNA. Translation: AAA37353.1.
AB008811 mRNA. Translation: BAA23549.1.
S45011 Genomic DNA. Translation: AAB23356.1.
IPIIPI00323134.
PIRIJMSCN. A32759.
RefSeqNP_031690.3.
XP_001472044.1.
UniGeneMm.257437

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NCGX-ray2.10A160-267[»]
1NCHX-ray2.10A/B160-267[»]
1NCIX-ray2.10A/B160-267[»]
1NCJX-ray3.40A160-374[»]
1OP4NMR-A24-159[»]
2QVIX-ray3.01A160-374[»]
SMRP15116. Positions 507-608, 836-901.
ModBaseSearch...

Protein-protein interaction databases

IntActP15116. 4 interactions.
STRINGP15116.

PTM databases

PhosphoSiteP15116.

Proteomic databases

PRIDEP15116.

Genome annotation databases

EnsemblENSMUST00000025166; ENSMUSP00000025166; ENSMUSG00000024304; Mus musculus. [Genome view]
ENSMUST00000115852; ENSMUSP00000111518; ENSMUSG00000024304; Mus musculus. [Genome view]
GeneID100044363.
12558.
KEGGmmu:100044363.
mmu:12558.

Organism-specific databases

CTD12558.
MGIMGI:88355. Cdh2.

Phylogenomic databases

eggNOGroNOG15574.
HOGENOMHBG505775.
HOVERGENP15116.
InParanoidP15116.

Gene expression databases

ArrayExpressP15116.
BgeeP15116.
CleanExMM_CDH2.
GenevestigatorP15116.
GermOnlineENSMUSG00000024304. Mus musculus.

Family and domain databases

InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro.
IPR009124. Desmocollin.
[Graphical view]
Gene3DG3DSA:2.60.40.60. Cadherin. 4 hits.
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameCADH2_MOUSE
AccessionPrimary (citable) accession number: P15116
Secondary accession number(s): Q64260
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: January 19, 2010
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents