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P15114

- MT2_CANGA

UniProt

P15114 - MT2_CANGA

Protein

Metallothionein-2

Gene

MT-II

more
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    The metallothioneins are involved in the cellular sequestration of toxic metal ions.

    GO - Molecular functioni

    1. copper ion binding Source: CGD

    GO - Biological processi

    1. cellular response to copper ion Source: CGD
    2. cellular response to silver ion Source: CGD

    Keywords - Ligandi

    Copper, Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-2
    Short name:
    MT-2
    Alternative name(s):
    Metallothionein-II
    Short name:
    MT-II
    Cleaved into the following chain:
    Metallothionein-2'
    Short name:
    MT-2'
    Alternative name(s):
    Metallothionein-II'
    Short name:
    MT-II'
    Gene namesi
    Name:MT-II
    Ordered Locus Names:CAGL0H04257g
    AND
    Name:MT-IIB
    Ordered Locus Names:CAGL0H04279g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome H

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 5251Metallothionein-2PRO_0000045887Add
    BLAST
    Chaini8 – 5245Metallothionein-2'PRO_0000045888Add
    BLAST

    Expressioni

    Inductioni

    Both MT-I and MT-II genes are regulated by copper ion in a concentration-dependent fashion, and both are inducible by silver but not by cadmium salts.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 475
    Repeati48 – 525

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    OMAiNCACENT.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15114-1 [UniParc]FASTAAdd to Basket

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    MPEQVNCQYD CHCSNCACEN TCNCCAKPAC ACTNSASNEC SCQTCKCQTC   50
    KC 52
    Length:52
    Mass (Da):5,585
    Last modified:January 23, 2007 - v2
    Checksum:iABD19E284CC34D22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05134 Genomic DNA. Translation: AAA35273.1.
    J05398 Genomic DNA. Translation: AAA35274.1.
    M86727 Genomic DNA. Translation: AAA35275.1.
    CR380954 Genomic DNA. Translation: CAG59913.1.
    CR380954 Genomic DNA. Translation: CAG59914.1.
    PIRiB31252.
    JC1197.
    RefSeqiXP_002999586.1. XM_002999540.1.
    XP_446980.1. XM_446980.1.
    XP_446981.1. XM_446981.1.

    Genome annotation databases

    GeneIDi2888780.
    2888781.
    9488054.
    KEGGicgr:CAGL0H04257g.
    cgr:CAGL0H04279g.
    cgr:CAGL0L01831g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05134 Genomic DNA. Translation: AAA35273.1 .
    J05398 Genomic DNA. Translation: AAA35274.1 .
    M86727 Genomic DNA. Translation: AAA35275.1 .
    CR380954 Genomic DNA. Translation: CAG59913.1 .
    CR380954 Genomic DNA. Translation: CAG59914.1 .
    PIRi B31252.
    JC1197.
    RefSeqi XP_002999586.1. XM_002999540.1.
    XP_446980.1. XM_446980.1.
    XP_446981.1. XM_446981.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2888780.
    2888781.
    9488054.
    KEGGi cgr:CAGL0H04257g.
    cgr:CAGL0H04279g.
    cgr:CAGL0L01831g.

    Phylogenomic databases

    OMAi NCACENT.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Candida glabrata metallothioneins. Cloning and sequence of the genes and characterization of proteins."
      Mehra R.K., Garey J.R., Butt T.R., Gray W.R., Winge D.R.
      J. Biol. Chem. 264:19747-19753(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20-39.
    2. "Selective and tandem amplification of a member of the metallothionein gene family in Candida glabrata."
      Mehra R.K., Garey J.R., Winge D.R.
      J. Biol. Chem. 265:6369-6375(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Disruption analysis of metallothionein-encoding genes in Candida glabrata."
      Mehra R.K., Thorvaldsen J.L., Macreadie I.G., Winge D.R.
      Gene 114:75-80(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.
    5. "Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata."
      Mehra R.K., Tarbet B.E., Gray W.R., Winge D.R.
      Proc. Natl. Acad. Sci. U.S.A. 85:8815-8819(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-20 AND 35-52.

    Entry informationi

    Entry nameiMT2_CANGA
    AccessioniPrimary (citable) accession number: P15114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    MT-II might bind nearly 10 mol eq of Cu+.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3