P15114 (MT2_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metallothionein-2
Short name=MT-2

Alternative name(s):
Metallothionein-II
Short name=MT-II

Cleaved into the following chain:

1. Metallothionein-2'
   Short name=MT-2'
   Alternative name(s):
   Metallothionein-II'
   Short name=MT-II'

Gene names

Name:	MT-II
Ordered Locus Names:	CAGL0H04257g
AND
Name:	MT-IIB
Ordered Locus Names:	CAGL0H04279g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces › Candida glabrata

Protein attributes

Sequence length	52 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The metallothioneins are involved in the cellular sequestration of toxic metal ions.
Induction	Both MT-I and MT-II genes are regulated by copper ion in a concentration-dependent fashion, and both are inducible by silver but not by cadmium salts.
Miscellaneous	MT-II might bind nearly 10 mol eq of Cu+.
Sequence similarities	Belongs to the metallothionein superfamily. Type 10 family.

Ontologies

Keywords
Domain	Repeat
Ligand	Copper Metal-binding Metal-thiolate cluster
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 52	51	Metallothionein-2		PRO_0000045887
	Chain	8 – 52	45	Metallothionein-2'		PRO_0000045888
Regions
	Repeat	43 – 47	5
	Repeat	48 – 52	5

Sequences

	Sequence		Length	Mass (Da)
	P15114 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: ABD19E284CC34D22	FASTA	52	5,585
	10 20 30 40 50 MPEQVNCQYD CHCSNCACEN TCNCCAKPAC ACTNSASNEC SCQTCKCQTC KC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Candida glabrata metallothioneins. Cloning and sequence of the genes and characterization of proteins." Mehra R.K., Garey J.R., Butt T.R., Gray W.R., Winge D.R. J. Biol. Chem. 264:19747-19753(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20-39.
[2]	"Selective and tandem amplification of a member of the metallothionein gene family in Candida glabrata." Mehra R.K., Garey J.R., Winge D.R. J. Biol. Chem. 265:6369-6375(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Disruption analysis of metallothionein-encoding genes in Candida glabrata." Mehra R.K., Thorvaldsen J.L., Macreadie I.G., Winge D.R. Gene 114:75-80(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.
[5]	"Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata." Mehra R.K., Tarbet B.E., Gray W.R., Winge D.R. Proc. Natl. Acad. Sci. U.S.A. 85:8815-8819(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-20 AND 35-52.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J05134 Genomic DNA. Translation: AAA35273.1. J05398 Genomic DNA. Translation: AAA35274.1. M86727 Genomic DNA. Translation: AAA35275.1. CR380954 Genomic DNA. Translation: CAG59913.1. CR380954 Genomic DNA. Translation: CAG59914.1.
PIR	B31252. JC1197.
RefSeq	XP_002999586.1. XM_002999540.1. XP_446980.1. XM_446980.1. XP_446981.1. XM_446981.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2888780. 2888781. 9488054.
KEGG	cgr:CAGL0H04257g. cgr:CAGL0H04279g. cgr:CAGL0L01831g.
Phylogenomic databases
OMA	CAENISS.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

MT2_CANGA

Accession

Primary (citable) accession number: P15114

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program