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Protein

Metallothionein-2

Gene

MT-II

more
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions.

Miscellaneous

MT-II might bind nearly 10 mol eq of Cu+.

GO - Molecular functioni

  • copper ion binding Source: CGD

GO - Biological processi

  • cellular response to copper ion Source: CGD
  • cellular response to silver ion Source: CGD

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
Metallothionein-II
Short name:
MT-II
Cleaved into the following chain:
Metallothionein-2'
Short name:
MT-2'
Alternative name(s):
Metallothionein-II'
Short name:
MT-II'
Gene namesi
Name:MT-II
Ordered Locus Names:CAGL0H04257g
AND
Name:MT-IIB
Ordered Locus Names:CAGL0H04279g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome H

Organism-specific databases

CGDiCAL0135114. CAGL0L01831g.
CAL0131544. MT-II.
CAL0129811. MT-IIB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000458872 – 52Metallothionein-2Add BLAST51
ChainiPRO_00000458888 – 52Metallothionein-2'Add BLAST45

Expressioni

Inductioni

Both MT-I and MT-II genes are regulated by copper ion in a concentration-dependent fashion, and both are inducible by silver but not by cadmium salts.

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_002999586.1.

Structurei

3D structure databases

SMRiP15114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 475
Repeati48 – 525

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiCACENTC.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQVNCQYD CHCSNCACEN TCNCCAKPAC ACTNSASNEC SCQTCKCQTC

KC
Length:52
Mass (Da):5,585
Last modified:January 23, 2007 - v2
Checksum:iABD19E284CC34D22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05134 Genomic DNA. Translation: AAA35273.1.
J05398 Genomic DNA. Translation: AAA35274.1.
M86727 Genomic DNA. Translation: AAA35275.1.
CR380954 Genomic DNA. Translation: CAG59913.1.
CR380954 Genomic DNA. Translation: CAG59914.1.
PIRiB31252.
JC1197.
RefSeqiXP_002999586.1. XM_002999540.1.
XP_446980.1. XM_446980.1.
XP_446981.1. XM_446981.1.

Genome annotation databases

EnsemblFungiiCAG59913; CAG59913; CAGL0H04257g.
CAG59914; CAG59914; CAGL0H04279g.
GeneIDi2888780.
2888781.
9488054.
KEGGicgr:CAGL0H04257g.
cgr:CAGL0H04279g.
cgr:CAGL0L01831g.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT2_CANGA
AccessioniPrimary (citable) accession number: P15114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families