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Protein

Metallothionein-2

Gene

MT-II

more
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions.

GO - Molecular functioni

  • copper ion binding Source: CGD

GO - Biological processi

  • cellular response to copper ion Source: CGD
  • cellular response to silver ion Source: CGD
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
Metallothionein-II
Short name:
MT-II
Cleaved into the following chain:
Metallothionein-2'
Short name:
MT-2'
Alternative name(s):
Metallothionein-II'
Short name:
MT-II'
Gene namesi
Name:MT-II
Ordered Locus Names:CAGL0H04257g
AND
Name:MT-IIB
Ordered Locus Names:CAGL0H04279g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428 Componenti: Chromosome H

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 5251Metallothionein-2PRO_0000045887Add
BLAST
Chaini8 – 5245Metallothionein-2'PRO_0000045888Add
BLAST

Expressioni

Inductioni

Both MT-I and MT-II genes are regulated by copper ion in a concentration-dependent fashion, and both are inducible by silver but not by cadmium salts.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 475
Repeati48 – 525

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiCAENISS.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQVNCQYD CHCSNCACEN TCNCCAKPAC ACTNSASNEC SCQTCKCQTC

KC
Length:52
Mass (Da):5,585
Last modified:January 23, 2007 - v2
Checksum:iABD19E284CC34D22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05134 Genomic DNA. Translation: AAA35273.1.
J05398 Genomic DNA. Translation: AAA35274.1.
M86727 Genomic DNA. Translation: AAA35275.1.
CR380954 Genomic DNA. Translation: CAG59913.1.
CR380954 Genomic DNA. Translation: CAG59914.1.
PIRiB31252.
JC1197.
RefSeqiXP_002999586.1. XM_002999540.1.
XP_446980.1. XM_446980.1.
XP_446981.1. XM_446981.1.

Genome annotation databases

GeneIDi2888780.
2888781.
9488054.
KEGGicgr:CAGL0H04257g.
cgr:CAGL0H04279g.
cgr:CAGL0L01831g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05134 Genomic DNA. Translation: AAA35273.1.
J05398 Genomic DNA. Translation: AAA35274.1.
M86727 Genomic DNA. Translation: AAA35275.1.
CR380954 Genomic DNA. Translation: CAG59913.1.
CR380954 Genomic DNA. Translation: CAG59914.1.
PIRiB31252.
JC1197.
RefSeqiXP_002999586.1. XM_002999540.1.
XP_446980.1. XM_446980.1.
XP_446981.1. XM_446981.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2888780.
2888781.
9488054.
KEGGicgr:CAGL0H04257g.
cgr:CAGL0H04279g.
cgr:CAGL0L01831g.

Phylogenomic databases

OMAiCAENISS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Candida glabrata metallothioneins. Cloning and sequence of the genes and characterization of proteins."
    Mehra R.K., Garey J.R., Butt T.R., Gray W.R., Winge D.R.
    J. Biol. Chem. 264:19747-19753(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 20-39.
  2. "Selective and tandem amplification of a member of the metallothionein gene family in Candida glabrata."
    Mehra R.K., Garey J.R., Winge D.R.
    J. Biol. Chem. 265:6369-6375(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Disruption analysis of metallothionein-encoding genes in Candida glabrata."
    Mehra R.K., Thorvaldsen J.L., Macreadie I.G., Winge D.R.
    Gene 114:75-80(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.
  5. "Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata."
    Mehra R.K., Tarbet B.E., Gray W.R., Winge D.R.
    Proc. Natl. Acad. Sci. U.S.A. 85:8815-8819(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-20 AND 35-52.

Entry informationi

Entry nameiMT2_CANGA
AccessioniPrimary (citable) accession number: P15114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

MT-II might bind nearly 10 mol eq of Cu+.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.