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Protein

Metallothionein-1

Gene

MT-I

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The metallothioneins are involved in the cellular sequestration of toxic metal ions.

Miscellaneous

MT-I might bind approximately 11-12 mol eq of Cu+.

GO - Molecular functioni

  • copper ion binding Source: CGD

GO - Biological processi

  • cellular response to copper ion Source: CGD
  • cellular response to silver ion Source: CGD

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:MT-I
Ordered Locus Names:CAGL0D01265g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome D

Organism-specific databases

CGDiCAL0128003. MT-I.
EuPathDBiFungiDB:CAGL0D01265g.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001973652 – 63Metallothionein-1Add BLAST62

Expressioni

Inductioni

Both MT-I and MT-II genes are regulated by copper ion in a concentration-dependent fashion, and both are inducible by silver but not by cadmium salts.

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_002999527.1.

Structurei

3D structure databases

ProteinModelPortaliP15113.
SMRiP15113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 308
Repeati56 – 638

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

OrthoDBiEOG092C5SLR.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDCKCPNG CSCPNCANGG CQCGDKCECK KQSCHGCGEQ CKCGSHGSSC
60
HGSCGCGDKC ECK
Length:63
Mass (Da):6,374
Last modified:January 23, 2007 - v2
Checksum:i80B1FE306C44BAEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05133 Genomic DNA. Translation: AAA35272.1.
CR380950 Genomic DNA. Translation: CAR58010.1.
PIRiA31252.
A34484.
RefSeqiXP_002999527.1. XM_002999481.1.

Genome annotation databases

EnsemblFungiiCAR58010; CAR58010; CAGL0D01265g.
GeneIDi9487975.
KEGGicgr:CAGL0D01265g.

Similar proteinsi

Entry informationi

Entry nameiMT1_CANGA
AccessioniPrimary (citable) accession number: P15113
Secondary accession number(s): B4UMY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families