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P15111

- DHE4_SALTY

UniProt

P15111 - DHE4_SALTY

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Protein

NADP-specific glutamate dehydrogenase

Gene
gdhA, STM1299
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia By similarity.

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei116 – 1161Substrate By similarity
Active sitei128 – 1281Proton donor By similarity
Binding sitei167 – 1671Substrate; via carbonyl oxygen By similarity
Sitei168 – 1681Important for catalysis By similarity
Binding sitei211 – 2111NADP By similarity
Binding sitei242 – 2421NADP By similarity
Binding sitei380 – 3801Substrate By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1310-MONOMER.
SABIO-RKP15111.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:STM1299
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447NADP-specific glutamate dehydrogenasePRO_0000182776Add
BLAST

Proteomic databases

PaxDbiP15111.
PRIDEiP15111.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

STRINGi99287.STM1299.

Structurei

3D structure databases

ProteinModelPortaliP15111.
SMRiP15111. Positions 6-447.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243799.
KOiK00262.
OMAiIMLDIHA.
OrthoDBiEOG65XN4D.
PhylomeDBiP15111.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15111-1 [UniParc]FASTAAdd to Basket

« Hide

MDQTCSLESF LNHVQKRDPH QTEFAQAVRE VMTTLWPFLE QNPRYRHMSL    50
LERLVEPERV IQFRVVWLDD KNQVQVNRAW RVQFNSAIGP YKGGMRFHPS 100
VNLSILKFLG FEQTFKNALT TLPMGGGKGG SDFDPKGKSE GEVMRFCQAL 150
MTELYRHLGP DTDVPAGDIG VGGREVGFMA GMMRKLSNNS SCVFTGKGLS 200
FGGSLIRPEA TGYGLVYFTE AMLKRHGLGF EGMRVAVSGS GNVAQYAIEK 250
AMAFGARVVT ASDSSGTVVD ESGFTPEKLA RLCEIKASRD GRVADYAREF 300
GLTYLEGQQP WSVPVDIALP CATQNELDVD AARVLIANGV KAVAEGANMP 350
TTIEATDLFL EAGVLFAPGK AANAGGVATS GLEMAQNAAR LSWKAEKVDA 400
RLHHIMLDIH HACVEYGGDN KHTNYVQGAN IAGFVKVADA MLAQGVI 447
Length:447
Mass (Da):48,574
Last modified:January 23, 2002 - v2
Checksum:iCB94B38B5042E0A2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991E → D in AAA27131. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24021 Genomic DNA. Translation: AAA27131.1.
AE006468 Genomic DNA. Translation: AAL20224.1.
PIRiA33504.
RefSeqiNP_460265.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20224; AAL20224; STM1299.
GeneIDi1252817.
KEGGistm:STM1299.
PATRICi32381075. VBISalEnt20916_1380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24021 Genomic DNA. Translation: AAA27131.1 .
AE006468 Genomic DNA. Translation: AAL20224.1 .
PIRi A33504.
RefSeqi NP_460265.1. NC_003197.1.

3D structure databases

ProteinModelPortali P15111.
SMRi P15111. Positions 6-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1299.

Proteomic databases

PaxDbi P15111.
PRIDEi P15111.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20224 ; AAL20224 ; STM1299 .
GeneIDi 1252817.
KEGGi stm:STM1299.
PATRICi 32381075. VBISalEnt20916_1380.

Phylogenomic databases

eggNOGi COG0334.
HOGENOMi HOG000243799.
KOi K00262.
OMAi IMLDIHA.
OrthoDBi EOG65XN4D.
PhylomeDBi P15111.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1310-MONOMER.
SABIO-RK P15111.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Affinity labeling of a glutamyl peptide in the coenzyme binding site of NADP+-specific glutamate dehydrogenase of Salmonella typhimurium by 2-[(4-bromo-2,3-dioxobutyl)thio]-1,N6-ethenoadenosine 2',5'-bisphosphate."
    Bansal A., Dayton M.A., Zalkin H., Colman R.F.
    J. Biol. Chem. 264:9827-9835(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiDHE4_SALTY
AccessioniPrimary (citable) accession number: P15111
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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