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P15110

- PCXB_BURCE

UniProt

P15110 - PCXB_BURCE

Protein

Protocatechuate 3,4-dioxygenase beta chain

Gene

pcaH

Organism
Burkholderia cepacia (Pseudomonas cepacia)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.

    Catalytic activityi

    3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate.

    Cofactori

    Binds Fe3+ ion per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi107 – 1071Iron; catalyticBy similarity
    Metal bindingi146 – 1461Iron; catalyticBy similarity
    Metal bindingi159 – 1591Iron; catalyticBy similarity
    Metal bindingi161 – 1611Iron; catalyticBy similarity

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. protocatechuate 3,4-dioxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-ketoadipate pathway Source: UniProtKB-UniPathway
    2. protocatechuate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00157; UER00264.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocatechuate 3,4-dioxygenase beta chain (EC:1.13.11.3)
    Alternative name(s):
    3,4-PCD
    Gene namesi
    Name:pcaH
    OrganismiBurkholderia cepacia (Pseudomonas cepacia)
    Taxonomic identifieri292 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Protocatechuate 3,4-dioxygenase beta chainPRO_0000085099Add
    BLAST

    Interactioni

    Subunit structurei

    The enzyme is an oligomer of 12 copies of the alpha and beta chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP15110.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.130.10. 1 hit.
    InterProiIPR000627. Intradiol_dOase_C.
    IPR015889. Intradiol_dOase_core.
    IPR024756. PCDO_beta_N.
    IPR012785. Protocat_dOase_b.
    [Graphical view]
    PfamiPF00775. Dioxygenase_C. 1 hit.
    PF12391. PCDO_beta_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49482. SSF49482. 1 hit.
    TIGRFAMsiTIGR02422. protocat_beta. 1 hit.
    PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15110-1 [UniParc]FASTAAdd to Basket

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    MDSPTILTPR DWPSHPAYVH PDYRSSVKRG PTRPMIPLKE RLRDQYAPVY    50
    GAEDLGPLDH DLTKNAVKNG EPLGERIVVT GRVLDEGGKP VRNTLVEVWQ 100
    ANAAGRYVHK VDQHDAPLDP NFLGAGRCMT DAEGRYRFLT IKPGAYPWGN 150
    HPNAWRPNHI HFSLFGDYFG SRLVTQMYFP GDPLLAYDPI FQGTPEAARD 200
    RLISRFSLDT TEEGHALGYE FDIVLRGRDA TPMER 235
    Length:235
    Mass (Da):26,550
    Last modified:April 1, 1990 - v1
    Checksum:iE8D00C95C8854324
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30791 Genomic DNA. Translation: AAA25924.1.
    PIRiB33487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30791 Genomic DNA. Translation: AAA25924.1 .
    PIRi B33487.

    3D structure databases

    ProteinModelPortali P15110.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00157 ; UER00264 .

    Family and domain databases

    Gene3Di 2.60.130.10. 1 hit.
    InterProi IPR000627. Intradiol_dOase_C.
    IPR015889. Intradiol_dOase_core.
    IPR024756. PCDO_beta_N.
    IPR012785. Protocat_dOase_b.
    [Graphical view ]
    Pfami PF00775. Dioxygenase_C. 1 hit.
    PF12391. PCDO_beta_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49482. SSF49482. 1 hit.
    TIGRFAMsi TIGR02422. protocat_beta. 1 hit.
    PROSITEi PS00083. INTRADIOL_DIOXYGENAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic organization and sequence of the Pseudomonas cepacia genes for the alpha and beta subunits of protocatechuate 3,4-dioxygenase."
      Zylstra G.J., Olsen R.H., Ballou D.P.
      J. Bacteriol. 171:5915-5921(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPCXB_BURCE
    AccessioniPrimary (citable) accession number: P15110
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3