Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P15109

- PCXA_BURCE

UniProt

P15109 - PCXA_BURCE

Protein

Protocatechuate 3,4-dioxygenase alpha chain

Gene

pcaG

Organism
Burkholderia cepacia (Pseudomonas cepacia)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an essential role in the utilization of numerous aromatic and hydroaromatic compounds via the beta-ketoadipate pathway.

    Catalytic activityi

    3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate.

    Cofactori

    Binds Fe3+ ion per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301ProtocatechuateSequence Analysis

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. protocatechuate 3,4-dioxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-ketoadipate pathway Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    UniPathwayiUPA00157; UER00264.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocatechuate 3,4-dioxygenase alpha chain (EC:1.13.11.3)
    Alternative name(s):
    3,4-PCD
    Gene namesi
    Name:pcaG
    OrganismiBurkholderia cepacia (Pseudomonas cepacia)
    Taxonomic identifieri292 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197Protocatechuate 3,4-dioxygenase alpha chainPRO_0000085096Add
    BLAST

    Interactioni

    Subunit structurei

    The enzyme is an oligomer of 12 copies of the alpha and beta chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP15109.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.60.130.10. 1 hit.
    InterProiIPR000627. Intradiol_dOase_C.
    IPR015889. Intradiol_dOase_core.
    IPR012786. Protocat_dOase_a.
    [Graphical view]
    PfamiPF00775. Dioxygenase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF49482. SSF49482. 1 hit.
    TIGRFAMsiTIGR02423. protocat_alph. 1 hit.
    PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15109-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTLKQTPSQ TVGPYFAYGL CPQQYGYDLK SLFTPTIAAP HADGEHVLLV    50
    GQVFDGDGNV VSDAMLEFTQ VDGAGRFPAS RDDVAKSGFT GFARVGTGTD 100
    AQHRFVVETV KPGRIAADEA PHINVTVMMR GILTHAFTRV YFDDEAAANA 150
    ADPVLNLVPA ERRATLVAKR DAQPGRPVVY RFDVRMQGPD ETVFFDV 197
    Length:197
    Mass (Da):21,394
    Last modified:April 1, 1990 - v1
    Checksum:iA00C1BCD420ECFC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30791 Genomic DNA. Translation: AAA25925.1.
    PIRiA33487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30791 Genomic DNA. Translation: AAA25925.1 .
    PIRi A33487.

    3D structure databases

    ProteinModelPortali P15109.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00157 ; UER00264 .

    Family and domain databases

    Gene3Di 2.60.130.10. 1 hit.
    InterProi IPR000627. Intradiol_dOase_C.
    IPR015889. Intradiol_dOase_core.
    IPR012786. Protocat_dOase_a.
    [Graphical view ]
    Pfami PF00775. Dioxygenase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49482. SSF49482. 1 hit.
    TIGRFAMsi TIGR02423. protocat_alph. 1 hit.
    PROSITEi PS00083. INTRADIOL_DIOXYGENAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic organization and sequence of the Pseudomonas cepacia genes for the alpha and beta subunits of protocatechuate 3,4-dioxygenase."
      Zylstra G.J., Olsen R.H., Ballou D.P.
      J. Bacteriol. 171:5915-5921(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPCXA_BURCE
    AccessioniPrimary (citable) accession number: P15109
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3