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P15106 (GLNA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:SCO2198
ORF Names:SC3H12.06
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulation

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

Subunit structure

Oligomer of 12 subunits arranged in the form of two hexagons.

Subcellular location

Cytoplasm.

Induction

Regulated in response to the available nitrogen source.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from mutant phenotype PubMed 10517584. Source: CACAO

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Glutamine synthetase
PRO_0000153266

Amino acid modifications

Modified residue3971O-AMP-tyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P15106 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 7C141D49C70FC437

FASTA46952,568
        10         20         30         40         50         60 
MFQNADDVKK FIADEDVKFV DVRFCDLPGV MQHFTLPATA FDPDAEQAFD GSSIRGFQAI 

        70         80         90        100        110        120 
HESDMSLRPD LSTARVDPFR RDKTLNINFF IHDPITGEQY SRDPRNVAKK AEAYLASTGI 

       130        140        150        160        170        180 
ADTAFFGPEA EFYVFDSVRF ATRENESFYH IDSEAGAWNT GALEDNRGYK VRYKGGYFPV 

       190        200        210        220        230        240 
PPVDHFADLR AEISLELERS GLQVERQHHE VGTAGQAEIN YKFNTLLAAA DDLQLFKYIV 

       250        260        270        280        290        300 
KNVAWKNGKT ATFMPKPIFG DNGSGMHVHQ SLWSGGEPLF YDEQGYAGLS DTARYYIGGI 

       310        320        330        340        350        360 
LKHAPSLLAF TNPTVNSYHR LVPGFEAPVN LVYSQRNRSA AMRIPITGSN PKAKRVEFRA 

       370        380        390        400        410        420 
PDASGNPYLA FSALLLAGLD GIKNKIEPAE PIDKDLYELA PEEHANVAQV PTSLGAVLDR 

       430        440        450        460 
LEADHEFLLQ GDVFTPDLIE TWIDFKRANE IAPLQLRPHP HEFEMYFDV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M23172 Genomic DNA. Translation: AAA72717.1.
AL939111 Genomic DNA. Translation: CAB90845.1.
PIRAJSMQC. JT0389.
RefSeqNP_626450.1. NC_003888.3.

3D structure databases

ProteinModelPortalP15106.
SMRP15106. Positions 3-469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO2198.

PTM databases

PhosSiteP12011306.

Proteomic databases

PRIDEP15106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB90845; CAB90845; CAB90845.
GeneID1097631.
KEGGsco:SCO2198.
PATRIC23734052. VBIStrCoe124346_2235.

Phylogenomic databases

eggNOGCOG0174.
HOGENOMHOG000005157.
KOK01915.
OMADMLLMPI.
OrthoDBEOG6B360N.
PhylomeDBP15106.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_STRCO
AccessionPrimary (citable) accession number: P15106
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 14, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families