SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P15103

- GLNA_BOVIN

UniProt

P15103 - GLNA_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glutamine synthetase
Gene
GLUL
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential for proliferation of fetal skin fibroblasts. This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner By similarity.

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.
L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Biotin By similarity.
Magnesium or manganese By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate decarboxylase activity Source: UniProtKB-EC
  3. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell proliferation Source: Ensembl
  2. glutamine biosynthetic process Source: InterPro
  3. response to glucose Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Lyase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_217400. Amino acid synthesis and interconversion (transamination).
REACT_219505. Astrocytic Glutamate-Glutamine Uptake And Metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate decarboxylase (EC:4.1.1.15)
Glutamate--ammonia ligase
Gene namesi
Name:GLUL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 16

Subcellular locationi

Cytoplasm By similarity. Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 373372Glutamine synthetase
PRO_0000153136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei104 – 1041Phosphotyrosine By similarity

Post-translational modificationi

Ubiquitinated by ZNRF1 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiP15103.

Interactioni

Subunit structurei

Homooctamer and homotetramer. Interacts with PALMD By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041778.

Structurei

3D structure databases

ProteinModelPortaliP15103.
SMRiP15103. Positions 3-372.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0174.
GeneTreeiENSGT00390000010047.
HOGENOMiHOG000061500.
HOVERGENiHBG005847.
InParanoidiP15103.
KOiK01915.
OMAiRIPRNVG.
OrthoDBiEOG7CZK5G.
TreeFamiTF300491.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15103-1 [UniParc]FASTAAdd to Basket

« Hide

MATSASSHLN KGIKQVYMAL PQGDKVQAMY IWIDGTGEGL RCKTRTLDSE    50
PKCIEELPEW NFDGSSTFQS EGSNSDMYLV PAAMFRDPFR KDPNKLVFCE 100
VFKYNRKPAE TNLRHTCKRI MDMVSNQRPW FGMEQEYTLM GTDGHPFGWP 150
SNGFPGPQGP YYCGVGADKA YGRDIVEAHY RACLYAGIKI GGTNAEVMPA 200
QWEFQIGPCE GIDMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA 250
GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL 300
TGFHETSNIN DFSAGVANRG ASIRIPRTVG QEKKGYFEDR RPSANCDPFA 350
VTEALIRTCL LNETGDEPFQ YKN 373
Length:373
Mass (Da):42,031
Last modified:January 23, 2007 - v4
Checksum:iBBCC6A953FD7DAD5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103099 mRNA. Translation: AAI03100.1.
Y10347 Genomic DNA. Translation: CAA71373.1. Sequence problems.
AY186585 mRNA. Translation: AAO27470.1.
J03604 mRNA. Translation: AAA87357.1.
PIRiA34006.
RefSeqiNP_001035564.1. NM_001040474.2.
XP_005217320.1. XM_005217263.1.
XP_005217321.1. XM_005217264.1.
UniGeneiBt.106825.

Genome annotation databases

EnsembliENSBTAT00000038488; ENSBTAP00000038301; ENSBTAG00000013631.
GeneIDi281199.
KEGGibta:281199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC103099 mRNA. Translation: AAI03100.1 .
Y10347 Genomic DNA. Translation: CAA71373.1 . Sequence problems.
AY186585 mRNA. Translation: AAO27470.1 .
J03604 mRNA. Translation: AAA87357.1 .
PIRi A34006.
RefSeqi NP_001035564.1. NM_001040474.2.
XP_005217320.1. XM_005217263.1.
XP_005217321.1. XM_005217264.1.
UniGenei Bt.106825.

3D structure databases

ProteinModelPortali P15103.
SMRi P15103. Positions 3-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000041778.

Proteomic databases

PRIDEi P15103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000038488 ; ENSBTAP00000038301 ; ENSBTAG00000013631 .
GeneIDi 281199.
KEGGi bta:281199.

Organism-specific databases

CTDi 2752.

Phylogenomic databases

eggNOGi COG0174.
GeneTreei ENSGT00390000010047.
HOGENOMi HOG000061500.
HOVERGENi HBG005847.
InParanoidi P15103.
KOi K01915.
OMAi RIPRNVG.
OrthoDBi EOG7CZK5G.
TreeFami TF300491.

Enzyme and pathway databases

Reactomei REACT_217400. Amino acid synthesis and interconversion (transamination).
REACT_219505. Astrocytic Glutamate-Glutamine Uptake And Metabolism.

Miscellaneous databases

NextBioi 20805255.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.
  2. "The bovine glutamine synthase gene (GLUL) maps to 10q33 and a pseudogene (GLULP) to 16q21."
    Masabanda J., Wigger G., Eggen A., Stranzinger G., Fries R.
    Mamm. Genome 8:794-795(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-267.
  3. "The pattern of EAAC1 and GLT-1 glutamate transporter expression by skeletal and adipose tissues of fattening cattle differs from that of glutamine synthetase."
    Matthews J.C., Etienne N.M.P.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 258-352.
    Tissue: Kidney.
  4. "Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver."
    Smith D.D. Jr., Campbell J.W.
    Proc. Natl. Acad. Sci. U.S.A. 85:160-164(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 267-373.
    Tissue: Liver.

Entry informationi

Entry nameiGLNA_BOVIN
AccessioniPrimary (citable) accession number: P15103
Secondary accession number(s): O02850, Q3ZBU6, Q866Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi