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P15103 (GLNA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

Short name=GS
EC=6.3.1.2
Alternative name(s):
Glutamate decarboxylase
EC=4.1.1.15
Glutamate--ammonia ligase
Gene names
Name:GLUL
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for proliferation of fetal skin fibroblasts. This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner By similarity.

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

L-glutamate = 4-aminobutanoate + CO2.

Cofactor

Biotin By similarity.

Magnesium or manganese By similarity.

Subunit structure

Homooctamer and homotetramer. Interacts with PALMD By similarity.

Subcellular location

Cytoplasm By similarity. Mitochondrion By similarity.

Post-translational modification

Ubiquitinated by ZNRF1 By similarity.

Sequence similarities

Belongs to the glutamine synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 373372Glutamine synthetase
PRO_0000153136

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1041Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P15103 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: BBCC6A953FD7DAD5

FASTA37342,031
        10         20         30         40         50         60 
MATSASSHLN KGIKQVYMAL PQGDKVQAMY IWIDGTGEGL RCKTRTLDSE PKCIEELPEW 

        70         80         90        100        110        120 
NFDGSSTFQS EGSNSDMYLV PAAMFRDPFR KDPNKLVFCE VFKYNRKPAE TNLRHTCKRI 

       130        140        150        160        170        180 
MDMVSNQRPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADKA YGRDIVEAHY 

       190        200        210        220        230        240 
RACLYAGIKI GGTNAEVMPA QWEFQIGPCE GIDMGDHLWV ARFILHRVCE DFGVIATFDP 

       250        260        270        280        290        300 
KPIPGNWNGA GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL 

       310        320        330        340        350        360 
TGFHETSNIN DFSAGVANRG ASIRIPRTVG QEKKGYFEDR RPSANCDPFA VTEALIRTCL 

       370 
LNETGDEPFQ YKN 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.
[2]"The bovine glutamine synthase gene (GLUL) maps to 10q33 and a pseudogene (GLULP) to 16q21."
Masabanda J., Wigger G., Eggen A., Stranzinger G., Fries R.
Mamm. Genome 8:794-795(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-267.
[3]"The pattern of EAAC1 and GLT-1 glutamate transporter expression by skeletal and adipose tissues of fattening cattle differs from that of glutamine synthetase."
Matthews J.C., Etienne N.M.P.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 258-352.
Tissue: Kidney.
[4]"Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver."
Smith D.D. Jr., Campbell J.W.
Proc. Natl. Acad. Sci. U.S.A. 85:160-164(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 267-373.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC103099 mRNA. Translation: AAI03100.1.
Y10347 Genomic DNA. Translation: CAA71373.1. Sequence problems.
AY186585 mRNA. Translation: AAO27470.1.
J03604 mRNA. Translation: AAA87357.1.
PIRA34006.
RefSeqNP_001035564.1. NM_001040474.2.
XP_005217320.1. XM_005217263.1.
XP_005217321.1. XM_005217264.1.
UniGeneBt.106825.

3D structure databases

ProteinModelPortalP15103.
SMRP15103. Positions 3-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000041778.

Proteomic databases

PRIDEP15103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000038488; ENSBTAP00000038301; ENSBTAG00000013631.
GeneID281199.
KEGGbta:281199.

Organism-specific databases

CTD2752.

Phylogenomic databases

eggNOGCOG0174.
GeneTreeENSGT00390000010047.
HOGENOMHOG000061500.
HOVERGENHBG005847.
InParanoidP15103.
KOK01915.
OMARIPRNVG.
OrthoDBEOG7CZK5G.
TreeFamTF300491.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805255.

Entry information

Entry nameGLNA_BOVIN
AccessionPrimary (citable) accession number: P15103
Secondary accession number(s): O02850, Q3ZBU6, Q866Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families