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Protein

Movement and silencing protein TGBp1

Gene

ORF2

Organism
Narcissus mosaic virus (NMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).By similarity

Miscellaneous

TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-cell propagation. TGBp1 is the main movement protein that physically cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would facilitate TGBp1 function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement and silencing protein TGBp1
Alternative name(s):
25 kDa protein
Silencing suppressor P25
Triple gene block 1 protein
Short name:
TGBp1
Gene namesi
ORF Names:ORF2
OrganismiNarcissus mosaic virus (NMV)
Taxonomic identifieri12180 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaePotexvirus
Virus hostiNarcissus pseudonarcissus (Daffodil) [TaxID: 39639]
Proteomesi
  • UP000008865 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002225671 – 233Movement and silencing protein TGBp1Add BLAST233

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with capsid protein. Interacts with host AGO1; this interaction targets the host protein for degradation, thereby suppressing the antiviral RNA silencing (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 134(+)RNA virus helicase ATP-bindingAdd BLAST134
Domaini135 – 233(+)RNA virus helicase C-terminalAdd BLAST99

Sequence similaritiesi

Belongs to the Tymovirales TGBp1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000NV.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01443. Viral_helicase1. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51657. PSRV_HELICASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P15096-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCKYLLELL DSYSFIRSSR SFSSPIIIHG VAGCGKSTII QKIALAFPEL
60 70 80 90 100
LIGSFTPALL DSNSGRKQLA VTSDPLDILD EYLGGPNPVV RLAKFCDPLQ
110 120 130 140 150
YSCEQPEVPH FTSLLTWRFC VRTTALLNGI FGCQIKSRRE DLCHLTHENP
160 170 180 190 200
YTTDPKGVVV AHEQEVINLL LQHGCPVTPT QHLWGLTIPV VSVYITSIAS
210 220 230
LSTVDRANLF LSLTRDSKAL HIFEFDAWSH ATC
Length:233
Mass (Da):25,846
Last modified:April 1, 1990 - v1
Checksum:iE38ECBED863EFA7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13747 Genomic RNA. Translation: BAA02892.1.
PIRiJT0471. WMWGN1.
RefSeqiNP_040779.1. NC_001441.1.

Genome annotation databases

GeneIDi1494020.
KEGGivg:1494020.

Similar proteinsi

Entry informationi

Entry nameiTGB1_NMV
AccessioniPrimary (citable) accession number: P15096
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 12, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families