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Protein

RNA replication protein

Gene
N/A
Organism
Narcissus mosaic virus (NMV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation
ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi868 – 875ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA replication protein
Alternative name(s):
186 kDa protein
ORF1 protein
Including the following 2 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
Helicase (EC:3.6.4.13)
OrganismiNarcissus mosaic virus (NMV)
Taxonomic identifieri12180 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaePotexvirus
Virus hostiNarcissus pseudonarcissus (Daffodil) [TaxID: 39639]
Proteomesi
  • UP000008865 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002225491 – 1643RNA replication proteinAdd BLAST1643

Proteomic databases

PRIDEiP15095.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 224Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST166
Domaini828 – 996(+)RNA virus helicase ATP-bindingAdd BLAST169
Domaini997 – 1132(+)RNA virus helicase C-terminalAdd BLAST136
Domaini1372 – 1479RdRp catalyticPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG0900004V.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
IPR002588. Alphavirus-like_MT_dom.
IPR027417. P-loop_NTPase.
IPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
PfamiView protein in Pfam
PF00978. RdRP_2. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF01660. Vmethyltransf. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51743. ALPHAVIRUS_MT. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.

Sequencei

Sequence statusi: Complete.

P15095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVRAALER IRDPSVQTAL SEAAYTHVRP VLKESLVNCP YALSNDEADC
60 70 80 90 100
LESFGITVNP YANQTHTHAA CKVIENRMLE IVGMHLPKHS CTMLFLKRSK
110 120 130 140 150
LRYMRRAAIL KDVFLNKDVE PKDLFRYDRD TIRSRLQDID TKIAYMSDTL
160 170 180 190 200
HFMSRREIVQ LFEDSPKLET LLATVVLPVE ALHKRTSLYP SLYSINYSAK
210 220 230 240 250
GFEYIPGNHG GGSYFHPYTT LEWLKVRMIN AEDFHKLSTG FILTFQLVES
260 270 280 290 300
LGANHLFIVQ KAKLLTPQMR TFCRDSLVTL PQVFCPAAMN ANRPLSKTKA
310 320 330 340 350
MQMLLYCKSV KQVTERDIYA KIRQIIPTSE LELYDPDEIV HLANYFFFVS
360 370 380 390 400
SLDSITCYED LLSSDIWMRL TRPLRTAVRK FVELFKGKQD FDKLLIALKW
410 420 430 440 450
QPFSYSLEPV DFTAYFVSRR VRTLAKMEDI SWHQAAELAR RLESEPDLLS
460 470 480 490 500
WEDLCSKPIA DPLASVSTPP LATLTSPAIS ESRVTDTSSP KLTNISVESI
510 520 530 540 550
LHPTSSNHAT IAESLNPKFC GWTRGDFHHM IVNQPSDRLK GCRSWSYTTS
560 570 580 590 600
PDVDLMLENL LLTPIPWESR LSDILLTLNT PANACCIQIL DCSAASAWVD
610 620 630 640 650
WSVQPIKTFP VAFVGMGETT LTFEDDSTLP LKEGEFVFFP PEWLARHKYQ
660 670 680 690 700
IKTASNLHLC ATFLVLDTTL LGETLANNCI EPEPLRPTAS RKSCQPTPSV
710 720 730 740 750
DKSGADSPPE KQIVTPIVDA AVLSCRPKLQ DVTKPTKVLM AAETSDSVAD
760 770 780 790 800
SLPWASWVNL LQKHGFKGNQ QQIAQDGQLI IPISDIRKLP HIPFPEEVPE
810 820 830 840 850
TLRETLKNIK RFPVEITMQH KRAGSYDSDI KNNRTGKLLS QMDNKWKAAF
860 870 880 890 900
AYKLQQEDRK VCGTIIHGCG GSGKSFAIQE WMRSLKEDQS VVTVVTPTVL
910 920 930 940 950
LRNDWQTKLP ILPADVFKTF EKSVIQPCNP ILVFDDYTKL PPGLIESVVM
960 970 980 990 1000
HHQNVVFIIL TGDNRQSVYH ETNPEAYIAA LPEAVEIFSP YCEFYLNATH
1010 1020 1030 1040 1050
RNVKDLANKL GVYSEREGKL KVNFASHHLK ASRIPMLVPS TMKRNAMFDM
1060 1070 1080 1090 1100
GHHSMTYAGC QGLTAPKIQI LLDNHTQFCS ERVLYTCLSR AVDRIHFINT
1110 1120 1130 1140 1150
GPTTGDYWAK LESTPYLKAF IDTYRDEKTE VYNSQPASAE PTEPEAPATH
1160 1170 1180 1190 1200
FPTAPKPLLE PLVEKLTDKE AREIFSPAFG HSNAIQTEDS VVQLFQHQQA
1210 1220 1230 1240 1250
KDETLYWATI DTRLAISTPE ANLREFNMKR DIGDILFMNY AKLMCLPPEP
1260 1270 1280 1290 1300
VPFEERLWKI SADEVRNTYI SKPIGNLVNA ASRQSPDFPK NKIALFLKSQ
1310 1320 1330 1340 1350
WVKKTEKLGT LKVKPGQTIA SFMQETVMLY GTMARYLRKM RRRFQPDNIF
1360 1370 1380 1390 1400
INCETTPEDL DKFIKSQWDF SRPAHTNDFT AFDQSQDGAM LQFEVIKAKF
1410 1420 1430 1440 1450
FNIPAEIIEG YIYIKLNAAI FLGTLGIMRL SGEGPTFDAN TECSIAYNAT
1460 1470 1480 1490 1500
RFHITDDTAQ VYAGDDMALD RVSIEKDSFN RLEKQLKLTS KPMFPKQVKG
1510 1520 1530 1540 1550
DYAEFCGWVM TPAGIIKHSL KMHASIQLQK KINNIKESAR SYALDLRYAY
1560 1570 1580 1590 1600
KLGDELQEHL NEVEADYHQQ SVRDMHLLHQ QDVLNKGSAS PPHVFEKTAD
1610 1620 1630 1640
ANTAGSSKTH KRNALKKKKQ TRIAEILPSP DATGLSSLPF RFF
Length:1,643
Mass (Da):186,305
Last modified:April 1, 1990 - v1
Checksum:iADAE6FCF0FF2EC43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13747 Genomic RNA. Translation: BAA02891.1.
PIRiJT0470. RRWGNV.
RefSeqiNP_040778.1. NC_001441.1.

Genome annotation databases

GeneIDi1494016.
KEGGivg:1494016.

Similar proteinsi

Entry informationi

Entry nameiRDRP_NMV
AccessioniPrimary (citable) accession number: P15095
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 12, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families