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Protein

Interferon-activable protein 204

Gene

Ifi204

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.7 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to interferon-alpha Source: UniProtKB
  • cellular response to interferon-beta Source: MGI
  • inner ear development Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • positive regulation of macrophage activation Source: CACAO
  • positive regulation of osteoblast differentiation Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-activable protein 204
Short name:
Ifi-204
Alternative name(s):
Interferon-inducible protein p204
Gene namesi
Name:Ifi204
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96429. Ifi204.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • membrane Source: MGI
  • nuclear inclusion body Source: UniProtKB
  • nuclear speck Source: MGI
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Interferon-activable protein 204PRO_0000153721Add
BLAST

Proteomic databases

MaxQBiP15092.
PaxDbiP15092.
PeptideAtlasiP15092.
PRIDEiP15092.

PTM databases

iPTMnetiP15092.
PhosphoSiteiP15092.

Expressioni

Tissue specificityi

Present in osteoblasts (at protein level).1 Publication

Inductioni

By beta interferon. By macrophage differentiation factors. During myocyte differentiation.1 Publication

Gene expression databases

CleanExiMM_IFI204.

Interactioni

Subunit structurei

Interacts with UBTF. Interacts with RUNX2. Interacts with ID1, ID2 and ID3.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200523. 2 interactions.
IntActiP15092. 1 interaction.
STRINGi10090.ENSMUSP00000106845.

Structurei

3D structure databases

ProteinModelPortaliP15092.
SMRiP15092. Positions 8-88, 244-435, 454-636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8888PyrinPROSITE-ProRule annotationAdd
BLAST
Repeati129 – 13571
Repeati136 – 14272
Repeati143 – 14973
Repeati150 – 15674
Repeati157 – 16375
Repeati164 – 17076
Repeati171 – 17777
Domaini234 – 434201HIN-200 1PROSITE-ProRule annotationAdd
BLAST
Domaini438 – 636199HIN-200 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 177497 X 7 AA tandem repeats of T-S-T-A-Q-A-[GR]Add
BLAST
Regioni571 – 63565Interaction with ID2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 3512Nuclear export signalAdd
BLAST
Motifi171 – 1788Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 2227Poly-Ser

Domaini

The 2 HIN-200 domains are able to interact with RUNX2.

Sequence similaritiesi

Belongs to the HIN-200 family.Curated
Contains 2 HIN-200 domains.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J5NP. Eukaryota.
ENOG410Y78B. LUCA.
HOGENOMiHOG000033871.
HOVERGENiHBG006122.
InParanoidiP15092.
PhylomeDBiP15092.

Family and domain databases

Gene3Di2.40.50.140. 4 hits.
InterProiIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF02760. HIN. 2 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
PROSITEiPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15092-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNEYKRIVL LRGLECINKH YFSLFKSLLA RDLNLERDNQ EQYTTIQIAN
60 70 80 90 100
MMEEKFPADS GLGKLIEFCE EVPALRKRAE ILKKERSEVT GETSLEKNGQ
110 120 130 140 150
EAGPATPTST TSHMLASERG ETSATQEETS TAQAGTSTAQ ARTSTAQART
160 170 180 190 200
STAQARTSTA QARTSTAQEG TSTAQKRKSM REEETGVKKS KAAKEPDQPP
210 220 230 240 250
CCEEPTAMCQ SPILHSSSSA SSNIPSAKNQ KSQPQNQNIP RGAVLHSEPL
260 270 280 290 300
TVMVLTATDP FEYESPEHEV KNMLHATVAT VSQYFHVKVF NINLKEKFTK
310 320 330 340 350
KNFIIISNYF ESKGILEINE TSSVLEAAPD QMIEVPNSII RNANASPKIC
360 370 380 390 400
DIQKGTSGAV FYGVFTLHKK TVNRKNTIYE IKDGSGSIEV VGSGKWHNIN
410 420 430 440 450
CKEGDKLHLF CFHLKTIDRQ PKLVCGEHSF IKISKRGNVP KEPAKEEDHH
460 470 480 490 500
HGPKQVMVLK VTEPFTYDLK EDKRMFHATV ATETEFFRVK VFDTALKSKF
510 520 530 540 550
IPRNIIAISD YFGCNGFLEI YRASCVSDVN VNPTMVISNT LRQRANATPK
560 570 580 590 600
ISYLFSQARG TFVSGEYLVN KKTERNKFIY YGIGDDTGKM EVVVYGRLTN
610 620 630 640
VRCEPGSKLR LVCFELTSTE DGWQLRSVRH SYMQVINARK
Length:640
Mass (Da):71,650
Last modified:May 20, 2008 - v2
Checksum:iCAA31FF316ECE857
GO
Isoform 2 (identifier: P15092-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-149: Missing.

Show »
Length:626
Mass (Da):70,219
Checksum:i8CB78CB11BDE09FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1691E → A in AAA39313 (PubMed:2477366).Curated
Sequence conflicti534 – 5341T → R in AAA39313 (PubMed:2477366).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 14914Missing in isoform 2. 2 PublicationsVSP_033655Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31419 mRNA. Translation: AAA39313.1.
CT010351 mRNA. Translation: CAJ18559.1.
BC010546 mRNA. Translation: AAH10546.1.
PIRiB34457.
RefSeqiNP_032355.2. NM_008329.2.
UniGeneiMm.261270.

Genome annotation databases

GeneIDi15951.
KEGGimmu:15951.
UCSCiuc029qut.1. mouse. [P15092-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31419 mRNA. Translation: AAA39313.1.
CT010351 mRNA. Translation: CAJ18559.1.
BC010546 mRNA. Translation: AAH10546.1.
PIRiB34457.
RefSeqiNP_032355.2. NM_008329.2.
UniGeneiMm.261270.

3D structure databases

ProteinModelPortaliP15092.
SMRiP15092. Positions 8-88, 244-435, 454-636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200523. 2 interactions.
IntActiP15092. 1 interaction.
STRINGi10090.ENSMUSP00000106845.

PTM databases

iPTMnetiP15092.
PhosphoSiteiP15092.

Proteomic databases

MaxQBiP15092.
PaxDbiP15092.
PeptideAtlasiP15092.
PRIDEiP15092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15951.
KEGGimmu:15951.
UCSCiuc029qut.1. mouse. [P15092-1]

Organism-specific databases

CTDi15951.
MGIiMGI:96429. Ifi204.

Phylogenomic databases

eggNOGiENOG410J5NP. Eukaryota.
ENOG410Y78B. LUCA.
HOGENOMiHOG000033871.
HOVERGENiHBG006122.
InParanoidiP15092.
PhylomeDBiP15092.

Miscellaneous databases

ChiTaRSiIfi204. mouse.
PROiP15092.
SOURCEiSearch...

Gene expression databases

CleanExiMM_IFI204.

Family and domain databases

Gene3Di2.40.50.140. 4 hits.
InterProiIPR004020. DAPIN.
IPR004021. HIN200/IF120x.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF02760. HIN. 2 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
PROSITEiPS50824. DAPIN. 1 hit.
PS50834. HIN_200. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFI4_MOUSE
AccessioniPrimary (citable) accession number: P15092
Secondary accession number(s): Q921V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.