Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mast cell carboxypeptidase A

Gene

CPA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi176Zinc; catalyticBy similarity1
Metal bindingi179Zinc; catalyticBy similarity1
Metal bindingi304Zinc; catalyticBy similarity1
Active sitei378Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • angiotensin maturation Source: Reactome
  • proteolysis Source: UniProtKB

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.17.1 2681
ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins

Protein family/group databases

MEROPSiM14.010

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell carboxypeptidase A (EC:3.4.17.1)
Short name:
MC-CPA
Alternative name(s):
Carboxypeptidase A3
Gene namesi
Name:CPA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163751.3
HGNCiHGNC:2298 CPA3
MIMi114851 gene
neXtProtiNX_P15088

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi1359
OpenTargetsiENSG00000163751
PharmGKBiPA26818

Chemistry databases

ChEMBLiCHEMBL2645

Polymorphism and mutation databases

BioMutaiCPA3
DMDMi317373331

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Add BLAST15
PropeptideiPRO_000000439516 – 109Activation peptide1 PublicationAdd BLAST94
ChainiPRO_0000004396110 – 417Mast cell carboxypeptidase AAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi173 ↔ 186By similarity
Disulfide bondi245 ↔ 268By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP15088
PeptideAtlasiP15088
PRIDEiP15088
ProteomicsDBi53105

2D gel databases

OGPiP15088

PTM databases

iPTMnetiP15088
PhosphoSitePlusiP15088

Expressioni

Gene expression databases

BgeeiENSG00000163751
CleanExiHS_CPA3
GenevisibleiP15088 HS

Organism-specific databases

HPAiCAB020712
HPA006479
HPA008689

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296046

Chemistry databases

BindingDBiP15088

Structurei

3D structure databases

ProteinModelPortaliP15088
SMRiP15088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650 Eukaryota
COG2866 LUCA
GeneTreeiENSGT00760000119103
HOGENOMiHOG000252968
HOVERGENiHBG050815
InParanoidiP15088
KOiK08780
OMAiQWFVYQA
OrthoDBiEOG091G0HUI
PhylomeDBiP15088
TreeFamiTF317197

Family and domain databases

CDDicd03871 M14_CPB, 1 hit
Gene3Di3.30.70.340, 1 hit
InterProiView protein in InterPro
IPR034253 CPB_M14_CPD
IPR036990 M14A-like_propep
IPR003146 M14A_act_pep
IPR000834 Peptidase_M14
PfamiView protein in Pfam
PF00246 Peptidase_M14, 1 hit
PF02244 Propep_M14, 1 hit
PRINTSiPR00765 CRBOXYPTASEA
SMARTiView protein in SMART
SM00631 Zn_pept, 1 hit
PROSITEiView protein in PROSITE
PS00133 CARBOXYPEPT_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLILPVGLI ATTLAIAPVR FDREKVFRVK PQDEKQADII KDLAKTNELD
60 70 80 90 100
FWYPGATHHV AANMMVDFRV SEKESQAIQS ALDQNKMHYE ILIHDLQEEI
110 120 130 140 150
EKQFDVKEDI PGRHSYAKYN NWEKIVAWTE KMMDKYPEMV SRIKIGSTVE
160 170 180 190 200
DNPLYVLKIG EKNERRKAIF TDCGIHAREW VSPAFCQWFV YQATKTYGRN
210 220 230 240 250
KIMTKLLDRM NFYILPVFNV DGYIWSWTKN RMWRKNRSKN QNSKCIGTDL
260 270 280 290 300
NRNFNASWNS IPNTNDPCAD NYRGSAPESE KETKAVTNFI RSHLNEIKVY
310 320 330 340 350
ITFHSYSQML LFPYGYTSKL PPNHEDLAKV AKIGTDVLST RYETRYIYGP
360 370 380 390 400
IESTIYPISG SSLDWAYDLG IKHTFAFELR DKGKFGFLLP ESRIKPTCRE
410
TMLAVKFIAK YILKHTS
Length:417
Mass (Da):48,670
Last modified:January 11, 2011 - v2
Checksum:iACB9038758117F9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63N → K in AAH12613 (PubMed:15489334).Curated1
Sequence conflicti146G → R in AAB22578 (PubMed:1629626).Curated1
Sequence conflicti301I → T in AAB22578 (PubMed:1629626).Curated1
Sequence conflicti355I → N in AAB22578 (PubMed:1629626).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04860281A → S. Corresponds to variant dbSNP:rs2270523Ensembl.1
Natural variantiVAR_033725171T → M4 PublicationsCorresponds to variant dbSNP:rs12489516Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27717 mRNA Translation: AAA35652.1
M73720
, M73716, M73717, M73718, M73719 Genomic DNA Translation: AAA59568.1
AC092979 Genomic DNA No translation available.
BC012613 mRNA Translation: AAH12613.1
S40234 mRNA Translation: AAB22578.2
CCDSiCCDS3138.1
PIRiA43929
RefSeqiNP_001861.2, NM_001870.3
UniGeneiHs.646

Genome annotation databases

EnsembliENST00000296046; ENSP00000296046; ENSG00000163751
GeneIDi1359
KEGGihsa:1359
UCSCiuc003ewm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCBPA3_HUMAN
AccessioniPrimary (citable) accession number: P15088
Secondary accession number(s): Q96E94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health