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Protein

Polymeric immunoglobulin receptor

Gene

Pigr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Cleaved into the following chain:
Gene namesi
Name:Pigr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3328 Pigr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 643ExtracellularSequence analysisAdd BLAST625
Transmembranei644 – 666HelicalSequence analysisAdd BLAST23
Topological domaini667 – 769CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000001490619 – 769Polymeric immunoglobulin receptorAdd BLAST751
ChainiPRO_000001490719 – 611Secretory componentAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 324PROSITE-ProRule annotation
Disulfide bondi370 ↔ 440PROSITE-ProRule annotation
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi484 ↔ 546PROSITE-ProRule annotation
Modified residuei678PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei740PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP15083
PRIDEiP15083

PTM databases

iPTMnetiP15083
PhosphoSitePlusiP15083

Interactioni

Protein-protein interaction databases

CORUMiP15083
STRINGi10116.ENSRNOP00000005853

Structurei

3D structure databases

ProteinModelPortaliP15083
SMRiP15083
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 126Ig-like V-type 1Add BLAST106
Domaini135 – 237Ig-like V-type 2Add BLAST103
Domaini240 – 341Ig-like V-type 3Add BLAST102
Domaini353 – 457Ig-like V-type 4Add BLAST105
Domaini463 – 563Ig-like V-type 5Add BLAST101

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHXB Eukaryota
ENOG41128ZA LUCA
HOGENOMiHOG000115545
HOVERGENiHBG008199
InParanoidiP15083
KOiK13073
PhylomeDBiP15083

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 4 hits
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00406 IGv, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSLFALLV TVFSGVSTQS PIFGPQDVSS IEGNSVSITC YYPDTSVNRH
60 70 80 90 100
TRKYWCRQGA NGYCATLISS NGYLSKEYSG RASLINFPEN STFVINIAHL
110 120 130 140 150
TQEDTGSYKC GLGTTNRGLF FDVSLEVSQV PEFPNDTHVY TKDIGRTVTI
160 170 180 190 200
ECRFKEGNAH SKKSLCKKRG EACEVVIDST EYVDPSYKDR AILFMKGTSR
210 220 230 240 250
DIFYVNISHL IPSDAGLYVC QAGEGPSADK NNADLQVLEP EPELLYKDLR
260 270 280 290 300
SSVTFECDLG REVANDAKYL CRKNKETCDV IINTLGKRDP AFEGRILLTP
310 320 330 340 350
RDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPVQA WQLFVNEEST
360 370 380 390 400
IPNSRSVVKG VTGGSVAIVC PYNPKESSSL KYWCHWEADE NGRCPVLVGT
410 420 430 440 450
QALVQEGYEG RLALFDQPGS GAYTVILNQL TTQDSGFYWC LTDGDSRWRT
460 470 480 490 500
TIELQVAEAT KKPDLEVTPQ NATAVIGETF TISCHYPCKF YSQEKYWCKW
510 520 530 540 550
SNDGCHILPS HDEGARQSSV SCDQSSQIVS MTLNPVKKED EGWYWCGVKE
560 570 580 590 600
GQVYGETTAI YVAVEERTRG SPHINPTDAN ARAKDAPEEE AMESSVREDE
610 620 630 640 650
NKANLDPRLF ADEREIQNAG DQAQENRASG NAGSAGGQSG SSKVLFSTLV
660 670 680 690 700
PLGLVLAVGA VAVWVARVRH RKNVDRMSIS SYRTDISMGD FRNSRDLGGN
710 720 730 740 750
DNMGATPDTQ ETVLEGKDEI ETTTECTTEP EESKKAKRSS KEEADMAYSA
760
FLFQSSTIAA QVHDGPQEA
Length:769
Mass (Da):84,798
Last modified:April 1, 1990 - v1
Checksum:i5F849303400255A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15741 mRNA Translation: CAA33758.1
PIRiS05407 QRRTGS
RefSeqiNP_036855.3, NM_012723.4
UniGeneiRn.234069
Rn.54456

Genome annotation databases

GeneIDi25046
KEGGirno:25046
UCSCiRGD:3328 rat

Similar proteinsi

Entry informationi

Entry nameiPIGR_RAT
AccessioniPrimary (citable) accession number: P15083
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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