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Protein

Polymeric immunoglobulin receptor

Gene

Pigr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Cleaved into the following chain:
Gene namesi
Name:Pigr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3328. Pigr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 643625ExtracellularSequence analysisAdd
BLAST
Transmembranei644 – 66623HelicalSequence analysisAdd
BLAST
Topological domaini667 – 769103CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • recycling endosome membrane Source: RGD
  • transport vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 769751Polymeric immunoglobulin receptorPRO_0000014906Add
BLAST
Chaini19 – 611593Secretory componentPRO_0000014907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 110PROSITE-ProRule annotation
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi257 ↔ 324PROSITE-ProRule annotation
Disulfide bondi370 ↔ 440PROSITE-ProRule annotation
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi484 ↔ 546PROSITE-ProRule annotation
Modified residuei678 – 6781PhosphoserineCombined sources
Modified residuei687 – 6871PhosphoserineCombined sources
Modified residuei694 – 6941PhosphoserineCombined sources
Modified residuei740 – 7401PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP15083.
PRIDEiP15083.

PTM databases

iPTMnetiP15083.
PhosphoSiteiP15083.

Interactioni

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: RGD

Protein-protein interaction databases

MINTiMINT-4588092.
STRINGi10116.ENSRNOP00000005853.

Structurei

3D structure databases

ProteinModelPortaliP15083.
SMRiP15083. Positions 20-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 126106Ig-like V-type 1Add
BLAST
Domaini135 – 237103Ig-like V-type 2Add
BLAST
Domaini240 – 341102Ig-like V-type 3Add
BLAST
Domaini353 – 457105Ig-like V-type 4Add
BLAST
Domaini463 – 563101Ig-like V-type 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiP15083.
KOiK13073.
PhylomeDBiP15083.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSLFALLV TVFSGVSTQS PIFGPQDVSS IEGNSVSITC YYPDTSVNRH
60 70 80 90 100
TRKYWCRQGA NGYCATLISS NGYLSKEYSG RASLINFPEN STFVINIAHL
110 120 130 140 150
TQEDTGSYKC GLGTTNRGLF FDVSLEVSQV PEFPNDTHVY TKDIGRTVTI
160 170 180 190 200
ECRFKEGNAH SKKSLCKKRG EACEVVIDST EYVDPSYKDR AILFMKGTSR
210 220 230 240 250
DIFYVNISHL IPSDAGLYVC QAGEGPSADK NNADLQVLEP EPELLYKDLR
260 270 280 290 300
SSVTFECDLG REVANDAKYL CRKNKETCDV IINTLGKRDP AFEGRILLTP
310 320 330 340 350
RDDNGRFSVL ITGLRKEDAG HYQCGAHSSG LPQEGWPVQA WQLFVNEEST
360 370 380 390 400
IPNSRSVVKG VTGGSVAIVC PYNPKESSSL KYWCHWEADE NGRCPVLVGT
410 420 430 440 450
QALVQEGYEG RLALFDQPGS GAYTVILNQL TTQDSGFYWC LTDGDSRWRT
460 470 480 490 500
TIELQVAEAT KKPDLEVTPQ NATAVIGETF TISCHYPCKF YSQEKYWCKW
510 520 530 540 550
SNDGCHILPS HDEGARQSSV SCDQSSQIVS MTLNPVKKED EGWYWCGVKE
560 570 580 590 600
GQVYGETTAI YVAVEERTRG SPHINPTDAN ARAKDAPEEE AMESSVREDE
610 620 630 640 650
NKANLDPRLF ADEREIQNAG DQAQENRASG NAGSAGGQSG SSKVLFSTLV
660 670 680 690 700
PLGLVLAVGA VAVWVARVRH RKNVDRMSIS SYRTDISMGD FRNSRDLGGN
710 720 730 740 750
DNMGATPDTQ ETVLEGKDEI ETTTECTTEP EESKKAKRSS KEEADMAYSA
760
FLFQSSTIAA QVHDGPQEA
Length:769
Mass (Da):84,798
Last modified:April 1, 1990 - v1
Checksum:i5F849303400255A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15741 mRNA. Translation: CAA33758.1.
PIRiS05407. QRRTGS.
RefSeqiNP_036855.3. NM_012723.4.
UniGeneiRn.234069.
Rn.54456.

Genome annotation databases

GeneIDi25046.
KEGGirno:25046.
UCSCiRGD:3328. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15741 mRNA. Translation: CAA33758.1.
PIRiS05407. QRRTGS.
RefSeqiNP_036855.3. NM_012723.4.
UniGeneiRn.234069.
Rn.54456.

3D structure databases

ProteinModelPortaliP15083.
SMRiP15083. Positions 20-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4588092.
STRINGi10116.ENSRNOP00000005853.

PTM databases

iPTMnetiP15083.
PhosphoSiteiP15083.

Proteomic databases

PaxDbiP15083.
PRIDEiP15083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25046.
KEGGirno:25046.
UCSCiRGD:3328. rat.

Organism-specific databases

CTDi5284.
RGDi3328. Pigr.

Phylogenomic databases

eggNOGiENOG410IHXB. Eukaryota.
ENOG41128ZA. LUCA.
HOGENOMiHOG000115545.
HOVERGENiHBG008199.
InParanoidiP15083.
KOiK13073.
PhylomeDBiP15083.

Miscellaneous databases

NextBioi605225.
PROiP15083.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 5 hits.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00406. IGv. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Intracellular targeting signals of polymeric immunoglobulin receptors are highly conserved between species."
    Banting G., Brake B., Braghetta P., Luzio J.P., Stanley K.K.
    FEBS Lett. 254:177-183(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678; SER-687 AND SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPIGR_RAT
AccessioniPrimary (citable) accession number: P15083
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.