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Protein

Glucitol operon repressor

Gene

srlR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi20 – 3920H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Phosphotransferase system, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00283.
ECOL316407:JW2676-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucitol operon repressor
Gene namesi
Name:srlR
Synonyms:gutR
Ordered Locus Names:b2707, JW2676
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10974. srlR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Glucitol operon repressorPRO_0000050268Add
BLAST

Proteomic databases

PaxDbiP15082.
PRIDEiP15082.

Expressioni

Inductioni

By glucitol.

Interactioni

Protein-protein interaction databases

BioGridi4263286. 13 interactions.
DIPiDIP-10919N.
IntActiP15082. 26 interactions.
MINTiMINT-1226226.
STRINGi511145.b2707.

Structurei

3D structure databases

ProteinModelPortaliP15082.
SMRiP15082. Positions 4-56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5856HTH deoR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH deoR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410804X. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224684.
InParanoidiP15082.
KOiK02468.
OMAiNTHKKAQ.
OrthoDBiEOG6XSZXW.
PhylomeDBiP15082.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPRQRQAAI LEYLQKQGKC SVEELAQYFD TTGTTIRKDL VILEHAGTVI
60 70 80 90 100
RTYGGVVLNK EESDPPIDHK TLINTHKKEL IAEAAVSFIH DGDSIILDAG
110 120 130 140 150
STVLQMVPLL SRFNNITVMT NSLHIVNALS ELDNEQTILM PGGTFRKKSA
160 170 180 190 200
SFHGQLAENA FEHFTFDKLF MGTDGIDLNA GVTTFNEVYT VSKAMCNAAR
210 220 230 240 250
EVILMADSSK FGRKSPNVVC SLESVDKLIT DAGIDPAFRQ ALEEKGIDVI

ITGESNE
Length:257
Mass (Da):28,236
Last modified:April 1, 1990 - v1
Checksum:iBAEAB73A51DD27A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02708 Genomic DNA. Translation: AAC13415.1.
X13463 Genomic DNA. Translation: CAA31820.1.
U29579 Genomic DNA. Translation: AAA69216.1.
U00096 Genomic DNA. Translation: AAC75749.1.
AP009048 Genomic DNA. Translation: BAA16568.2.
PIRiS01832.
RefSeqiNP_417187.1. NC_000913.3.
WP_000804550.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75749; AAC75749; b2707.
BAA16568; BAA16568; BAA16568.
GeneIDi948942.
KEGGiecj:JW2676.
eco:b2707.
PATRICi32120812. VBIEscCol129921_2798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02708 Genomic DNA. Translation: AAC13415.1.
X13463 Genomic DNA. Translation: CAA31820.1.
U29579 Genomic DNA. Translation: AAA69216.1.
U00096 Genomic DNA. Translation: AAC75749.1.
AP009048 Genomic DNA. Translation: BAA16568.2.
PIRiS01832.
RefSeqiNP_417187.1. NC_000913.3.
WP_000804550.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP15082.
SMRiP15082. Positions 4-56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263286. 13 interactions.
DIPiDIP-10919N.
IntActiP15082. 26 interactions.
MINTiMINT-1226226.
STRINGi511145.b2707.

Proteomic databases

PaxDbiP15082.
PRIDEiP15082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75749; AAC75749; b2707.
BAA16568; BAA16568; BAA16568.
GeneIDi948942.
KEGGiecj:JW2676.
eco:b2707.
PATRICi32120812. VBIEscCol129921_2798.

Organism-specific databases

EchoBASEiEB0967.
EcoGeneiEG10974. srlR.

Phylogenomic databases

eggNOGiENOG410804X. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224684.
InParanoidiP15082.
KOiK02468.
OMAiNTHKKAQ.
OrthoDBiEOG6XSZXW.
PhylomeDBiP15082.

Enzyme and pathway databases

BioCyciEcoCyc:PD00283.
ECOL316407:JW2676-MONOMER.

Miscellaneous databases

PROiP15082.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli."
    Yamada M., Saier M.H. Jr.
    J. Mol. Biol. 203:569-583(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-177.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiSRLR_ECOLI
AccessioniPrimary (citable) accession number: P15082
Secondary accession number(s): P77030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: January 20, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.