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Protein

Peptide transporter CstA

Gene

cstA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peptide utilization during carbon starvation.1 Publication

GO - Biological processi

  • cellular response to starvation Source: EcoCyc
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processPeptide transport, Protein transport, Stress response, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10167-MONOMER

Protein family/group databases

TCDBi2.A.114.1.1 the putative peptide transporter carbon starvation csta (csta) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide transporter CstACurated
Alternative name(s):
Carbon starvation protein ACurated
Gene namesi
Name:cstA1 Publication
Synonyms:ybdC
Ordered Locus Names:b0598, JW0590
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10167 cstA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicCurated6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 33PeriplasmicCurated6
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 86CytoplasmicCuratedAdd BLAST32
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 117PeriplasmicCurated10
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 160CytoplasmicCuratedAdd BLAST22
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 189PeriplasmicCurated8
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 217CytoplasmicCurated7
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 255PeriplasmicCuratedAdd BLAST17
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 280CytoplasmicCurated4
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 324PeriplasmicCuratedAdd BLAST23
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 372CytoplasmicCuratedAdd BLAST27
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 395PeriplasmicCurated2
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 439CytoplasmicCuratedAdd BLAST23
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 463PeriplasmicCurated3
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 523CytoplasmicCuratedAdd BLAST39
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 550PeriplasmicCurated6
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 577CytoplasmicCurated6
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 643PeriplasmicCuratedAdd BLAST45
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 701Cytoplasmic1 PublicationAdd BLAST37

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900461 – 701Peptide transporter CstAAdd BLAST701

Proteomic databases

PaxDbiP15078
PRIDEiP15078

Expressioni

Inductioni

Induced by carbon starvation. Induction requires the cAMP-cAMP receptor protein (CRP) complex (PubMed:1848300). The carbon storage regulator CsrA regulates translation of cstA by sterically interfering with ribosome binding (PubMed:12867454).2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4260985, 5 interactors
STRINGi316385.ECDH10B_0666

Structurei

3D structure databases

ProteinModelPortaliP15078
SMRiP15078
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D22 Bacteria
COG1966 LUCA
HOGENOMiHOG000220271
InParanoidiP15078
KOiK06200
OMAiMLAESFV
PhylomeDBiP15078

Family and domain databases

InterProiView protein in InterPro
IPR025299 CstA_C
IPR003706 CstA_N
PfamiView protein in Pfam
PF02554 CstA, 1 hit
PF13722 CstA_5TM, 1 hit

Sequencei

Sequence statusi: Complete.

P15078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSGKYLVW TVLSVMGAFA LGYIALNRGE QINALWIVVA SVCIYLIAYR
60 70 80 90 100
FYGLYIAKNV LAVDPTRMTP AVRHNDGLDY VPTDKKVLFG HHFAAIAGAG
110 120 130 140 150
PLVGPVLAAQ MGYLPGMIWL LAGVVLAGAV QDFMVLFVST RRDGRSLGEL
160 170 180 190 200
VKEEMGPTAG VIALVACFMI MVIILAVLAM IVVKALTHSP WGTYTVAFTI
210 220 230 240 250
PLALFMGIYL RYLRPGRIGE VSVIGLVFLI FAIISGGWVA ESPTWAPYFD
260 270 280 290 300
FTGVQLTWML VGYGFVAAVL PVWLLLAPRD YLSTFLKIGT IVGLAVGILI
310 320 330 340 350
MRPTLTMPAL TKFVDGTGPV WTGNLFPFLF ITIACGAVSG FHALISSGTT
360 370 380 390 400
PKMLANEGQA CFIGYGGMLM ESFVAIMALV SACIIDPGVY FAMNSPMAVL
410 420 430 440 450
APAGTADVVA SAAQVVSSWG FSITPDTLNQ IASEVGEQSI ISRAGGAPTL
460 470 480 490 500
AVGMAYILHG ALGGMMDVAF WYHFAILFEA LFILTAVDAG TRAARFMLQD
510 520 530 540 550
LLGVVSPGLK RTDSLPANLL ATALCVLAWG YFLHQGVVDP LGGINTLWPL
560 570 580 590 600
FGIANQMLAG MALMLCAVVL FKMKRQRYAW VALVPTAWLL ICTLTAGWQK
610 620 630 640 650
AFSPDAKVGF LAIANKFQAM IDSGNIPSQY TESQLAQLVF NNRLDAGLTI
660 670 680 690 700
FFMVVVVVLA LFSIKTALAA LKDPKPTAKE TPYEPMPENV EEIVAQAKGA

H
Length:701
Mass (Da):75,105
Last modified:November 1, 1997 - v3
Checksum:i2DA85B2D96FD19E5
GO

Sequence cautioni

The sequence CAA37087 differs from that shown. Reason: Frameshift at position 543.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129A → G in CAA37086 (PubMed:1848300).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52904 Genomic DNA Translation: CAA37086.1 Frameshift.
X52904 Genomic DNA Translation: CAA37087.1 Frameshift.
U82598 Genomic DNA Translation: AAB40798.1
U00096 Genomic DNA Translation: AAC73699.1
AP009048 Genomic DNA Translation: BAA35227.1
M24148 Unassigned DNA No translation available.
PIRiD64793 Q0ECNA
RefSeqiNP_415130.1, NC_000913.3
WP_001043156.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73699; AAC73699; b0598
BAA35227; BAA35227; BAA35227
GeneIDi945213
KEGGiecj:JW0590
eco:b0598
PATRICifig|1411691.4.peg.1671

Similar proteinsi

Entry informationi

Entry nameiCSTA_ECOLI
AccessioniPrimary (citable) accession number: P15078
Secondary accession number(s): P23517, P77740
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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