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Protein

Carbon starvation protein A

Gene

cstA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Peptide utilization during carbon starvation.

GO - Biological processi

  • cellular response to starvation Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciEcoCyc:EG10167-MONOMER.
ECOL316407:JW0590-MONOMER.

Protein family/group databases

TCDBi2.A.114.1.1. the putative peptide transporter carbon starvation csta (csta) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbon starvation protein A
Gene namesi
Name:cstA
Synonyms:ybdC
Ordered Locus Names:b0598, JW0590
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10167. cstA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 33PeriplasmicSequence analysis6
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 86CytoplasmicSequence analysisAdd BLAST32
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 117PeriplasmicSequence analysis10
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 161CytoplasmicSequence analysisAdd BLAST23
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 189PeriplasmicSequence analysis7
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 217CytoplasmicSequence analysis7
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 255PeriplasmicSequence analysisAdd BLAST17
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 280CytoplasmicSequence analysis4
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 324PeriplasmicSequence analysisAdd BLAST23
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 372CytoplasmicSequence analysisAdd BLAST27
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 395PeriplasmicSequence analysis2
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 439CytoplasmicSequence analysisAdd BLAST23
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461 – 463PeriplasmicSequence analysis3
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 523CytoplasmicSequence analysisAdd BLAST39
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 550PeriplasmicSequence analysis6
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 577CytoplasmicSequence analysis6
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 643PeriplasmicSequence analysisAdd BLAST45
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 701CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900461 – 701Carbon starvation protein AAdd BLAST701

Proteomic databases

PaxDbiP15078.
PRIDEiP15078.

Expressioni

Inductioni

By carbon starvation.

Interactioni

Protein-protein interaction databases

BioGridi4260985. 5 interactors.
STRINGi511145.b0598.

Structurei

3D structure databases

ProteinModelPortaliP15078.
SMRiP15078.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CstA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D22. Bacteria.
COG1966. LUCA.
HOGENOMiHOG000220271.
InParanoidiP15078.
KOiK06200.
OMAiWGFSISA.
PhylomeDBiP15078.

Family and domain databases

InterProiIPR025299. CstA_C.
IPR003706. CstA_N.
[Graphical view]
PfamiPF02554. CstA. 1 hit.
PF13722. CstA_5TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSGKYLVW TVLSVMGAFA LGYIALNRGE QINALWIVVA SVCIYLIAYR
60 70 80 90 100
FYGLYIAKNV LAVDPTRMTP AVRHNDGLDY VPTDKKVLFG HHFAAIAGAG
110 120 130 140 150
PLVGPVLAAQ MGYLPGMIWL LAGVVLAGAV QDFMVLFVST RRDGRSLGEL
160 170 180 190 200
VKEEMGPTAG VIALVACFMI MVIILAVLAM IVVKALTHSP WGTYTVAFTI
210 220 230 240 250
PLALFMGIYL RYLRPGRIGE VSVIGLVFLI FAIISGGWVA ESPTWAPYFD
260 270 280 290 300
FTGVQLTWML VGYGFVAAVL PVWLLLAPRD YLSTFLKIGT IVGLAVGILI
310 320 330 340 350
MRPTLTMPAL TKFVDGTGPV WTGNLFPFLF ITIACGAVSG FHALISSGTT
360 370 380 390 400
PKMLANEGQA CFIGYGGMLM ESFVAIMALV SACIIDPGVY FAMNSPMAVL
410 420 430 440 450
APAGTADVVA SAAQVVSSWG FSITPDTLNQ IASEVGEQSI ISRAGGAPTL
460 470 480 490 500
AVGMAYILHG ALGGMMDVAF WYHFAILFEA LFILTAVDAG TRAARFMLQD
510 520 530 540 550
LLGVVSPGLK RTDSLPANLL ATALCVLAWG YFLHQGVVDP LGGINTLWPL
560 570 580 590 600
FGIANQMLAG MALMLCAVVL FKMKRQRYAW VALVPTAWLL ICTLTAGWQK
610 620 630 640 650
AFSPDAKVGF LAIANKFQAM IDSGNIPSQY TESQLAQLVF NNRLDAGLTI
660 670 680 690 700
FFMVVVVVLA LFSIKTALAA LKDPKPTAKE TPYEPMPENV EEIVAQAKGA

H
Length:701
Mass (Da):75,105
Last modified:November 1, 1997 - v3
Checksum:i2DA85B2D96FD19E5
GO

Sequence cautioni

The sequence CAA37087 differs from that shown. Reason: Frameshift at position 543.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129A → G in CAA37086 (PubMed:1848300).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52904 Genomic DNA. Translation: CAA37086.1. Frameshift.
X52904 Genomic DNA. Translation: CAA37087.1. Frameshift.
U82598 Genomic DNA. Translation: AAB40798.1.
U00096 Genomic DNA. Translation: AAC73699.1.
AP009048 Genomic DNA. Translation: BAA35227.1.
M24148 Unassigned DNA. No translation available.
PIRiD64793. Q0ECNA.
RefSeqiNP_415130.1. NC_000913.3.
WP_001043156.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73699; AAC73699; b0598.
BAA35227; BAA35227; BAA35227.
GeneIDi945213.
KEGGiecj:JW0590.
eco:b0598.
PATRICi32116372. VBIEscCol129921_0626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52904 Genomic DNA. Translation: CAA37086.1. Frameshift.
X52904 Genomic DNA. Translation: CAA37087.1. Frameshift.
U82598 Genomic DNA. Translation: AAB40798.1.
U00096 Genomic DNA. Translation: AAC73699.1.
AP009048 Genomic DNA. Translation: BAA35227.1.
M24148 Unassigned DNA. No translation available.
PIRiD64793. Q0ECNA.
RefSeqiNP_415130.1. NC_000913.3.
WP_001043156.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP15078.
SMRiP15078.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260985. 5 interactors.
STRINGi511145.b0598.

Protein family/group databases

TCDBi2.A.114.1.1. the putative peptide transporter carbon starvation csta (csta) family.

Proteomic databases

PaxDbiP15078.
PRIDEiP15078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73699; AAC73699; b0598.
BAA35227; BAA35227; BAA35227.
GeneIDi945213.
KEGGiecj:JW0590.
eco:b0598.
PATRICi32116372. VBIEscCol129921_0626.

Organism-specific databases

EchoBASEiEB0165.
EcoGeneiEG10167. cstA.

Phylogenomic databases

eggNOGiENOG4105D22. Bacteria.
COG1966. LUCA.
HOGENOMiHOG000220271.
InParanoidiP15078.
KOiK06200.
OMAiWGFSISA.
PhylomeDBiP15078.

Enzyme and pathway databases

BioCyciEcoCyc:EG10167-MONOMER.
ECOL316407:JW0590-MONOMER.

Miscellaneous databases

PROiP15078.

Family and domain databases

InterProiIPR025299. CstA_C.
IPR003706. CstA_N.
[Graphical view]
PfamiPF02554. CstA. 1 hit.
PF13722. CstA_5TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSTA_ECOLI
AccessioniPrimary (citable) accession number: P15078
Secondary accession number(s): P23517, P77740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.