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Protein

Flagellar motor switch protein FliN

Gene

fliN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

FliN is one of three proteins (FliG, FliN, FliM) that form a switch complex that is proposed to be located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Flagellar rotation

Enzyme and pathway databases

BioCyciEcoCyc:FLIN-FLAGELLAR-C-RING-SWITCH.
ECOL316407:JW1930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar motor switch protein FliN
Gene namesi
Name:fliN
Synonyms:flaN, motD
Ordered Locus Names:b1946, JW1930
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10324. fliN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Bacterial flagellum, Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841181 – 137Flagellar motor switch protein FliNAdd BLAST137

Proteomic databases

PaxDbiP15070.
PRIDEiP15070.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fliMP069747EBI-2011987,EBI-560439

Protein-protein interaction databases

BioGridi4261042. 373 interactors.
DIPiDIP-1101N.
IntActiP15070. 10 interactors.
STRINGi511145.b1946.

Structurei

3D structure databases

ProteinModelPortaliP15070.
SMRiP15070.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FliN/MopA/SpaO family.Curated

Phylogenomic databases

eggNOGiENOG4105DD5. Bacteria.
COG1886. LUCA.
HOGENOMiHOG000253569.
InParanoidiP15070.
KOiK02417.
OMAiMWADAMS.
PhylomeDBiP15070.

Family and domain databases

InterProiIPR012826. FliN.
IPR031576. FliN_N.
IPR001172. FliN_T3SS_HrcQb.
IPR001543. SpoA.
[Graphical view]
PfamiPF01052. FliMN_C. 1 hit.
PF16973. FliN_N. 1 hit.
[Graphical view]
PRINTSiPR00956. FLGMOTORFLIN.
SUPFAMiSSF101801. SSF101801. 1 hit.
TIGRFAMsiTIGR02480. fliN. 1 hit.

Sequencei

Sequence statusi: Complete.

P15070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDMNNPADD NNGAMDDLWA EALSEQKSTS SKSAAETVFQ QFGGGDVSGT
60 70 80 90 100
LQDIDLIMDI PVKLTVELGR TRMTIKELLR LTQGSVVALD GLAGEPLDIL
110 120 130
INGYLIAQGE VVVVADKYGV RITDIITPSE RMRRLSR
Length:137
Mass (Da):14,855
Last modified:April 1, 1990 - v1
Checksum:i93A77AE3FEF33091
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26294 Unassigned DNA. Translation: AAA03207.1.
U00096 Genomic DNA. Translation: AAC75013.1.
AP009048 Genomic DNA. Translation: BAA15771.1.
PIRiJS0111. XMECII.
RefSeqiNP_416456.1. NC_000913.3.
WP_001282101.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75013; AAC75013; b1946.
BAA15771; BAA15771; BAA15771.
GeneIDi946423.
KEGGiecj:JW1930.
eco:b1946.
PATRICi32119221. VBIEscCol129921_2025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26294 Unassigned DNA. Translation: AAA03207.1.
U00096 Genomic DNA. Translation: AAC75013.1.
AP009048 Genomic DNA. Translation: BAA15771.1.
PIRiJS0111. XMECII.
RefSeqiNP_416456.1. NC_000913.3.
WP_001282101.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP15070.
SMRiP15070.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261042. 373 interactors.
DIPiDIP-1101N.
IntActiP15070. 10 interactors.
STRINGi511145.b1946.

Proteomic databases

PaxDbiP15070.
PRIDEiP15070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75013; AAC75013; b1946.
BAA15771; BAA15771; BAA15771.
GeneIDi946423.
KEGGiecj:JW1930.
eco:b1946.
PATRICi32119221. VBIEscCol129921_2025.

Organism-specific databases

EchoBASEiEB0320.
EcoGeneiEG10324. fliN.

Phylogenomic databases

eggNOGiENOG4105DD5. Bacteria.
COG1886. LUCA.
HOGENOMiHOG000253569.
InParanoidiP15070.
KOiK02417.
OMAiMWADAMS.
PhylomeDBiP15070.

Enzyme and pathway databases

BioCyciEcoCyc:FLIN-FLAGELLAR-C-RING-SWITCH.
ECOL316407:JW1930-MONOMER.

Miscellaneous databases

PROiP15070.

Family and domain databases

InterProiIPR012826. FliN.
IPR031576. FliN_N.
IPR001172. FliN_T3SS_HrcQb.
IPR001543. SpoA.
[Graphical view]
PfamiPF01052. FliMN_C. 1 hit.
PF16973. FliN_N. 1 hit.
[Graphical view]
PRINTSiPR00956. FLGMOTORFLIN.
SUPFAMiSSF101801. SSF101801. 1 hit.
TIGRFAMsiTIGR02480. fliN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFLIN_ECOLI
AccessioniPrimary (citable) accession number: P15070
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.