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Protein

Transcription factor jun-D

Gene

Jund

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites.By similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. double-stranded DNA binding Source: Ensembl
  3. enzyme binding Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  6. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to calcium ion Source: MGI
  3. circadian rhythm Source: Ensembl
  4. osteoblast development Source: MGI
  5. positive regulation of osteoblast differentiation Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  7. response to light stimulus Source: Ensembl
  8. response to lipopolysaccharide Source: Ensembl
  9. response to mechanical stimulus Source: Ensembl
  10. response to organic cyclic compound Source: Ensembl
  11. response to peptide hormone Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:Jund
Synonyms:Jun-d, Jund1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:96648. Jund.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Transcription factor jun-DPRO_0000076443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451PhosphoserineBy similarity
Modified residuei249 – 2491PhosphoserineBy similarity
Modified residuei253 – 2531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15066.
PaxDbiP15066.
PRIDEiP15066.

PTM databases

PhosphoSiteiP15066.

Expressioni

Tissue specificityi

Brain and kidney.

Gene expression databases

BgeeiP15066.
CleanExiMM_JUND.
GenevestigatoriP15066.

Interactioni

Subunit structurei

Binds DNA as a dimer (By similarity). Interacts with MEN1.By similarity1 Publication

Protein-protein interaction databases

BioGridi200873. 6 interactions.
IntActiP15066. 2 interactions.
MINTiMINT-4099238.
STRINGi10090.ENSMUSP00000092901.

Structurei

3D structure databases

ProteinModelPortaliP15066.
SMRiP15066. Positions 267-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini262 – 32564bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 28928Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni290 – 31829Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283376.
GeneTreeiENSGT00390000009929.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP15066.
KOiK04449.
OMAiAPVYANL.
OrthoDBiEOG75MVXV.
PhylomeDBiP15066.
TreeFamiTF323952.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029823. JunD.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF7. PTHR11462:SF7. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15066-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METPFYGEEA LSGLAAGASS VAGATGAPGG GGFAPPGRAF PGAPPTSSML
60 70 80 90 100
KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA
210 220 230 240 250
ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP
260 270 280 290 300
PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ
310 320 330 340
NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y
Length:341
Mass (Da):34,905
Last modified:April 1, 1990 - v1
Checksum:i2727392F6B65188D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51F → L in AAA39345. (PubMed:2104845)Curated
Sequence conflicti61 – 622EQ → DE in AAA39345. (PubMed:2104845)Curated
Sequence conflicti317 – 3182QL → HV in AAA39345. (PubMed:2104845)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04509 Genomic DNA. Translation: AAA39344.1.
X15358 mRNA. Translation: CAA33418.1.
J05205 mRNA. Translation: AAA39345.1.
BC010572 mRNA. Translation: AAH10572.1.
CCDSiCCDS40375.1.
PIRiA32158. TVMSJD.
RefSeqiNP_034722.1. NM_010592.5.
UniGeneiMm.419851.

Genome annotation databases

EnsembliENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076.
GeneIDi16478.
KEGGimmu:16478.
UCSCiuc009mbe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04509 Genomic DNA. Translation: AAA39344.1.
X15358 mRNA. Translation: CAA33418.1.
J05205 mRNA. Translation: AAA39345.1.
BC010572 mRNA. Translation: AAH10572.1.
CCDSiCCDS40375.1.
PIRiA32158. TVMSJD.
RefSeqiNP_034722.1. NM_010592.5.
UniGeneiMm.419851.

3D structure databases

ProteinModelPortaliP15066.
SMRiP15066. Positions 267-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200873. 6 interactions.
IntActiP15066. 2 interactions.
MINTiMINT-4099238.
STRINGi10090.ENSMUSP00000092901.

PTM databases

PhosphoSiteiP15066.

Proteomic databases

MaxQBiP15066.
PaxDbiP15066.
PRIDEiP15066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076.
GeneIDi16478.
KEGGimmu:16478.
UCSCiuc009mbe.2. mouse.

Organism-specific databases

CTDi3727.
MGIiMGI:96648. Jund.

Phylogenomic databases

eggNOGiNOG283376.
GeneTreeiENSGT00390000009929.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP15066.
KOiK04449.
OMAiAPVYANL.
OrthoDBiEOG75MVXV.
PhylomeDBiP15066.
TreeFamiTF323952.

Miscellaneous databases

ChiTaRSiJund. mouse.
NextBioi289771.
PROiP15066.
SOURCEiSearch...

Gene expression databases

BgeeiP15066.
CleanExiMM_JUND.
GenevestigatoriP15066.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR029823. JunD.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR11462:SF7. PTHR11462:SF7. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of junD: a new member of the jun proto-oncogene family."
    Hirai S., Ryseck R.P., Mechta F., Bravo R., Yaniv M.
    EMBO J. 8:1433-1439(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor."
    Li L., Hu J.-S., Olson E.N.
    J. Biol. Chem. 265:1556-1562(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
    Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., Saggar S., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L.
    Cell 96:143-152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEN1.

Entry informationi

Entry nameiJUND_MOUSE
AccessioniPrimary (citable) accession number: P15066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 4, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.