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P15066

- JUND_MOUSE

UniProt

P15066 - JUND_MOUSE

Protein

Transcription factor jun-D

Gene

Jund

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Transcription factor binding AP-1 sites.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. double-stranded DNA binding Source: Ensembl
    3. protein binding Source: MGI
    4. sequence-specific DNA binding Source: Ensembl
    5. sequence-specific DNA binding transcription factor activity Source: Ensembl
    6. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to calcium ion Source: MGI
    3. circadian rhythm Source: Ensembl
    4. osteoblast development Source: MGI
    5. positive regulation of osteoblast differentiation Source: MGI
    6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    7. response to light stimulus Source: Ensembl
    8. response to lipopolysaccharide Source: Ensembl
    9. response to mechanical stimulus Source: Ensembl
    10. response to organic cyclic compound Source: Ensembl
    11. response to peptide hormone Source: Ensembl
    12. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor jun-D
    Gene namesi
    Name:Jund
    Synonyms:Jun-d, Jund1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:96648. Jund.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Transcription factor jun-DPRO_0000076443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei245 – 2451PhosphoserineBy similarity
    Modified residuei249 – 2491PhosphoserineBy similarity
    Modified residuei253 – 2531PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP15066.
    PRIDEiP15066.

    PTM databases

    PhosphoSiteiP15066.

    Expressioni

    Tissue specificityi

    Brain and kidney.

    Gene expression databases

    BgeeiP15066.
    CleanExiMM_JUND.
    GenevestigatoriP15066.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer By similarity. Interacts with MEN1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi200873. 5 interactions.
    IntActiP15066. 2 interactions.
    MINTiMINT-4099238.
    STRINGi10090.ENSMUSP00000092901.

    Structurei

    3D structure databases

    ProteinModelPortaliP15066.
    SMRiP15066. Positions 267-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini262 – 32564bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni262 – 28928Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni290 – 31829Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Jun subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG283376.
    GeneTreeiENSGT00390000009929.
    HOGENOMiHOG000006648.
    HOVERGENiHBG001722.
    InParanoidiP15066.
    KOiK04449.
    OMAiTQFLYPK.
    OrthoDBiEOG75MVXV.
    PhylomeDBiP15066.
    TreeFamiTF323952.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view]
    PRINTSiPR00043. LEUZIPPRJUN.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15066-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPFYGEEA LSGLAAGASS VAGATGAPGG GGFAPPGRAF PGAPPTSSML    50
    KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS 100
    PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ 150
    SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA 200
    ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP 250
    PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ 300
    NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y 341
    Length:341
    Mass (Da):34,905
    Last modified:April 1, 1990 - v1
    Checksum:i2727392F6B65188D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51F → L in AAA39345. (PubMed:2104845)Curated
    Sequence conflicti61 – 622EQ → DE in AAA39345. (PubMed:2104845)Curated
    Sequence conflicti317 – 3182QL → HV in AAA39345. (PubMed:2104845)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04509 Genomic DNA. Translation: AAA39344.1.
    X15358 mRNA. Translation: CAA33418.1.
    J05205 mRNA. Translation: AAA39345.1.
    BC010572 mRNA. Translation: AAH10572.1.
    CCDSiCCDS40375.1.
    PIRiA32158. TVMSJD.
    RefSeqiNP_034722.1. NM_010592.5.
    UniGeneiMm.419851.

    Genome annotation databases

    EnsembliENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076.
    GeneIDi16478.
    KEGGimmu:16478.
    UCSCiuc009mbe.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04509 Genomic DNA. Translation: AAA39344.1 .
    X15358 mRNA. Translation: CAA33418.1 .
    J05205 mRNA. Translation: AAA39345.1 .
    BC010572 mRNA. Translation: AAH10572.1 .
    CCDSi CCDS40375.1.
    PIRi A32158. TVMSJD.
    RefSeqi NP_034722.1. NM_010592.5.
    UniGenei Mm.419851.

    3D structure databases

    ProteinModelPortali P15066.
    SMRi P15066. Positions 267-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200873. 5 interactions.
    IntActi P15066. 2 interactions.
    MINTi MINT-4099238.
    STRINGi 10090.ENSMUSP00000092901.

    PTM databases

    PhosphoSitei P15066.

    Proteomic databases

    PaxDbi P15066.
    PRIDEi P15066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095267 ; ENSMUSP00000092901 ; ENSMUSG00000071076 .
    GeneIDi 16478.
    KEGGi mmu:16478.
    UCSCi uc009mbe.2. mouse.

    Organism-specific databases

    CTDi 3727.
    MGIi MGI:96648. Jund.

    Phylogenomic databases

    eggNOGi NOG283376.
    GeneTreei ENSGT00390000009929.
    HOGENOMi HOG000006648.
    HOVERGENi HBG001722.
    InParanoidi P15066.
    KOi K04449.
    OMAi TQFLYPK.
    OrthoDBi EOG75MVXV.
    PhylomeDBi P15066.
    TreeFami TF323952.

    Miscellaneous databases

    NextBioi 289771.
    PROi P15066.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15066.
    CleanExi MM_JUND.
    Genevestigatori P15066.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view ]
    PRINTSi PR00043. LEUZIPPRJUN.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Characterization of junD: a new member of the jun proto-oncogene family."
      Hirai S., Ryseck R.P., Mechta F., Bravo R., Yaniv M.
      EMBO J. 8:1433-1439(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor."
      Li L., Hu J.-S., Olson E.N.
      J. Biol. Chem. 265:1556-1562(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    5. "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
      Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., Saggar S., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L.
      Cell 96:143-152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEN1.

    Entry informationi

    Entry nameiJUND_MOUSE
    AccessioniPrimary (citable) accession number: P15066
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3