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P15066

- JUND_MOUSE

UniProt

P15066 - JUND_MOUSE

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Protein

Transcription factor jun-D

Gene
Jund, Jun-d, Jund1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites By similarity.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. double-stranded DNA binding Source: Ensembl
  3. protein binding Source: MGI
  4. sequence-specific DNA binding Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: Ensembl
  6. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to calcium ion Source: MGI
  3. circadian rhythm Source: Ensembl
  4. osteoblast development Source: MGI
  5. positive regulation of osteoblast differentiation Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  7. response to light stimulus Source: Ensembl
  8. response to lipopolysaccharide Source: Ensembl
  9. response to mechanical stimulus Source: Ensembl
  10. response to organic cyclic compound Source: Ensembl
  11. response to peptide hormone Source: Ensembl
  12. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:Jund
Synonyms:Jun-d, Jund1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:96648. Jund.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Transcription factor jun-DPRO_0000076443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451Phosphoserine By similarity
Modified residuei249 – 2491Phosphoserine By similarity
Modified residuei253 – 2531Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP15066.
PRIDEiP15066.

PTM databases

PhosphoSiteiP15066.

Expressioni

Tissue specificityi

Brain and kidney.

Gene expression databases

BgeeiP15066.
CleanExiMM_JUND.
GenevestigatoriP15066.

Interactioni

Subunit structurei

Binds DNA as a dimer By similarity. Interacts with MEN1.1 Publication

Protein-protein interaction databases

BioGridi200873. 5 interactions.
IntActiP15066. 2 interactions.
MINTiMINT-4099238.
STRINGi10090.ENSMUSP00000092901.

Structurei

3D structure databases

ProteinModelPortaliP15066.
SMRiP15066. Positions 267-318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini262 – 32564bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 28928Basic motif By similarityAdd
BLAST
Regioni290 – 31829Leucine-zipper By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.

Phylogenomic databases

eggNOGiNOG283376.
GeneTreeiENSGT00390000009929.
HOGENOMiHOG000006648.
HOVERGENiHBG001722.
InParanoidiP15066.
KOiK04449.
OMAiTQFLYPK.
OrthoDBiEOG75MVXV.
PhylomeDBiP15066.
TreeFamiTF323952.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15066-1 [UniParc]FASTAAdd to Basket

« Hide

METPFYGEEA LSGLAAGASS VAGATGAPGG GGFAPPGRAF PGAPPTSSML    50
KKDALTLSLA EQGAAGLKPG SATAPSALRP DGAPDGLLAS PDLGLLKLAS 100
PELERLIIQS NGLVTTTPTS TQFLYPKVAA SEEQEFAEGF VKALEDLHKQ 150
SQLGAATAAT SGAPAPPAPA DLAATPGATE TPVYANLSSF AGGAGPPGGA 200
ATVAFAAEPV PFPPPPGALG PPPPPHPPRL AALKDEPQTV PDVPSFGDSP 250
PLSPIDMDTQ ERIKAERKRL RNRIAASKCR KRKLERISRL EEKVKTLKSQ 300
NTELASTASL LREQVAQLKQ KVLSHVNSGC QLLPQHQVPA Y 341
Length:341
Mass (Da):34,905
Last modified:April 1, 1990 - v1
Checksum:i2727392F6B65188D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51F → L in AAA39345. 1 Publication
Sequence conflicti61 – 622EQ → DE in AAA39345. 1 Publication
Sequence conflicti317 – 3182QL → HV in AAA39345. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04509 Genomic DNA. Translation: AAA39344.1.
X15358 mRNA. Translation: CAA33418.1.
J05205 mRNA. Translation: AAA39345.1.
BC010572 mRNA. Translation: AAH10572.1.
CCDSiCCDS40375.1.
PIRiA32158. TVMSJD.
RefSeqiNP_034722.1. NM_010592.5.
UniGeneiMm.419851.

Genome annotation databases

EnsembliENSMUST00000095267; ENSMUSP00000092901; ENSMUSG00000071076.
GeneIDi16478.
KEGGimmu:16478.
UCSCiuc009mbe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04509 Genomic DNA. Translation: AAA39344.1 .
X15358 mRNA. Translation: CAA33418.1 .
J05205 mRNA. Translation: AAA39345.1 .
BC010572 mRNA. Translation: AAH10572.1 .
CCDSi CCDS40375.1.
PIRi A32158. TVMSJD.
RefSeqi NP_034722.1. NM_010592.5.
UniGenei Mm.419851.

3D structure databases

ProteinModelPortali P15066.
SMRi P15066. Positions 267-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200873. 5 interactions.
IntActi P15066. 2 interactions.
MINTi MINT-4099238.
STRINGi 10090.ENSMUSP00000092901.

PTM databases

PhosphoSitei P15066.

Proteomic databases

PaxDbi P15066.
PRIDEi P15066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095267 ; ENSMUSP00000092901 ; ENSMUSG00000071076 .
GeneIDi 16478.
KEGGi mmu:16478.
UCSCi uc009mbe.2. mouse.

Organism-specific databases

CTDi 3727.
MGIi MGI:96648. Jund.

Phylogenomic databases

eggNOGi NOG283376.
GeneTreei ENSGT00390000009929.
HOGENOMi HOG000006648.
HOVERGENi HBG001722.
InParanoidi P15066.
KOi K04449.
OMAi TQFLYPK.
OrthoDBi EOG75MVXV.
PhylomeDBi P15066.
TreeFami TF323952.

Miscellaneous databases

NextBioi 289771.
PROi P15066.
SOURCEi Search...

Gene expression databases

Bgeei P15066.
CleanExi MM_JUND.
Genevestigatori P15066.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view ]
PRINTSi PR00043. LEUZIPPRJUN.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of junD: a new member of the jun proto-oncogene family."
    Hirai S., Ryseck R.P., Mechta F., Bravo R., Yaniv M.
    EMBO J. 8:1433-1439(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor."
    Li L., Hu J.-S., Olson E.N.
    J. Biol. Chem. 265:1556-1562(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription."
    Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., Saggar S., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L.
    Cell 96:143-152(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEN1.

Entry informationi

Entry nameiJUND_MOUSE
AccessioniPrimary (citable) accession number: P15066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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