Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transforming protein p68/c-ets-1

Gene

ETS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi379 – 45981ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein p68/c-ets-1
Gene namesi
Name:ETS1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Transforming protein p68/c-ets-1PRO_0000204073Add
BLAST

Proteomic databases

PaxDbiP15062.

Expressioni

Tissue specificityi

Spleen.

Interactioni

Subunit structurei

Binds DNA as a homodimer; homodimerization is required for transcription activation.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001717.

Structurei

3D structure databases

ProteinModelPortaliP15062.
SMRiP15062. Positions 73-182, 341-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 18086PNTPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 287114Activation domain; required for transcription activationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15062.
PhylomeDBiP15062.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform p68 (identifier: P15062-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSYYMDTTI GSTGPYPLAR PGVMQGASSC CEDPWMPCRL QSACCPPRSC
60 70 80 90 100
CPPWDEAAIQ EVPTGLEHYS TDMECADVPL LTPSSKEMMS QALKATFSGF
110 120 130 140 150
AKEQQRLGIP KDPQQWTETH VRDWVMWAVN EFSLKGVDFQ KFCMNGAALC
160 170 180 190 200
ALGKECFLEL APDFVGDILW EHLEILQKEE AKPYPANGVN AAYPESRYTS
210 220 230 240 250
DYFISYGIEH AQCVPPSEFS EPSFITESYQ TLHPISSEEL LSLKYENDYP
260 270 280 290 300
SVILRDPVQT DSLQTDYFTI KQEVVTPDNM CMGRASRGKL GGQDSFESIE
310 320 330 340 350
SYDSCDRLTQ SWSSQSSFQS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD
360 370 380 390 400
YVRDRADMNK DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW
410 420 430 440 450
TGDGWEFKLS DPDEVARRWG KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA
460 470 480
GKRYVYRFVC DLQSLLGYTP EELHAMLDVK PDADE
Length:485
Mass (Da):55,021
Last modified:August 1, 1990 - v1
Checksum:i81576B43BEF62648
GO
Isoform p54 (identifier: P13474-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P13474.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:441
Mass (Da):50,327
GO

Sequence cautioni

The sequence AAA48668 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201S → C in AAA48668 (PubMed:3284179).Curated
Sequence conflicti222 – 2221P → R in AAA48668 (PubMed:3284179).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21823 mRNA. Translation: AAA48669.1.
AH002441 Genomic DNA. Translation: AAA48668.1. Different initiation.
PIRiA28875. TVCHET.
UniGeneiGga.13782.

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21823 mRNA. Translation: AAA48669.1.
AH002441 Genomic DNA. Translation: AAA48668.1. Different initiation.
PIRiA28875. TVCHET.
UniGeneiGga.13782.

3D structure databases

ProteinModelPortaliP15062.
SMRiP15062. Positions 73-182, 341-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001717.

Proteomic databases

PaxDbiP15062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15062.
PhylomeDBiP15062.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETS1B_CHICK
AccessioniPrimary (citable) accession number: P15062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.