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P15037

- ETS2_MOUSE

UniProt

P15037 - ETS2_MOUSE

Protein

Protein C-ets-2

Gene

Ets2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi362 – 44281ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
    2. sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    4. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_188971. Oncogene Induced Senescence.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein C-ets-2
    Gene namesi
    Name:Ets2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:95456. Ets2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Protein C-ets-2PRO_0000204078Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei220 – 2201PhosphoserineBy similarity
    Modified residuei225 – 2251PhosphoserineBy similarity
    Modified residuei294 – 2941PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP15037.

    PTM databases

    PhosphoSiteiP15037.

    Expressioni

    Gene expression databases

    ArrayExpressiP15037.
    BgeeiP15037.
    CleanExiMM_ETS2.
    GenevestigatoriP15037.

    Interactioni

    Protein-protein interaction databases

    BioGridi204766. 5 interactions.
    DIPiDIP-41847N.
    MINTiMINT-194890.
    STRINGi10090.ENSMUSP00000023612.

    Structurei

    3D structure databases

    ProteinModelPortaliP15037.
    SMRiP15037. Positions 76-170, 328-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 17086PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG305402.
    HOGENOMiHOG000285953.
    HOVERGENiHBG003088.
    InParanoidiP15037.
    KOiK02678.
    OMAiFGMNGQV.
    OrthoDBiEOG77127T.
    PhylomeDBiP15037.
    TreeFamiTF316214.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016311. Transform_prot_C-ets.
    IPR027276. Transform_prot_C-ets-2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF501032. C-ets-2. 1 hit.
    PIRSF001698. Transforming_factor_C-ets. 1 hit.
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15037-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ    50
    EVPTGLDSVS HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP 100
    KNPWLWSEQQ VCQWLLWATN EFSLVNVNLH QFGMNGQMLC NLGKERFLEL 150
    APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLNAVPHW INSNTLGFSM 200
    EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK SRLNTVNVNY 250
    CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS 300
    LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA 350
    AVLAGFTGSG PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR 400
    RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG 450
    FTPEELHAIL GVQPDTED 468
    Length:468
    Mass (Da):52,827
    Last modified:April 1, 1990 - v1
    Checksum:i5260F3085B7EB831
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04103 mRNA. Translation: AAA37581.1.
    BC005504 mRNA. Translation: AAH05504.1.
    CCDSiCCDS37412.1.
    PIRiC32066. TVMSE2.
    RefSeqiNP_035939.3. NM_011809.3.
    UniGeneiMm.290207.

    Genome annotation databases

    EnsembliENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895.
    GeneIDi23872.
    KEGGimmu:23872.
    UCSCiuc008ace.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04103 mRNA. Translation: AAA37581.1 .
    BC005504 mRNA. Translation: AAH05504.1 .
    CCDSi CCDS37412.1.
    PIRi C32066. TVMSE2.
    RefSeqi NP_035939.3. NM_011809.3.
    UniGenei Mm.290207.

    3D structure databases

    ProteinModelPortali P15037.
    SMRi P15037. Positions 76-170, 328-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204766. 5 interactions.
    DIPi DIP-41847N.
    MINTi MINT-194890.
    STRINGi 10090.ENSMUSP00000023612.

    PTM databases

    PhosphoSitei P15037.

    Proteomic databases

    PRIDEi P15037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023612 ; ENSMUSP00000023612 ; ENSMUSG00000022895 .
    GeneIDi 23872.
    KEGGi mmu:23872.
    UCSCi uc008ace.2. mouse.

    Organism-specific databases

    CTDi 2114.
    MGIi MGI:95456. Ets2.

    Phylogenomic databases

    eggNOGi NOG305402.
    HOGENOMi HOG000285953.
    HOVERGENi HBG003088.
    InParanoidi P15037.
    KOi K02678.
    OMAi FGMNGQV.
    OrthoDBi EOG77127T.
    PhylomeDBi P15037.
    TreeFami TF316214.

    Enzyme and pathway databases

    Reactomei REACT_188971. Oncogene Induced Senescence.

    Miscellaneous databases

    ChiTaRSi ETS2. mouse.
    NextBioi 303583.
    PROi P15037.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15037.
    Bgeei P15037.
    CleanExi MM_ETS2.
    Genevestigatori P15037.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016311. Transform_prot_C-ets.
    IPR027276. Transform_prot_C-ets-2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF501032. C-ets-2. 1 hit.
    PIRSF001698. Transforming_factor_C-ets. 1 hit.
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiETS2_MOUSE
    AccessioniPrimary (citable) accession number: P15037
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3