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P15037

- ETS2_MOUSE

UniProt

P15037 - ETS2_MOUSE

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Protein

Protein C-ets-2

Gene

Ets2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi362 – 44281ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  4. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_188971. Oncogene Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:Ets2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:95456. Ets2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Protein C-ets-2PRO_0000204078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei225 – 2251PhosphoserineBy similarity
Modified residuei294 – 2941PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15037.
PRIDEiP15037.

PTM databases

PhosphoSiteiP15037.

Expressioni

Gene expression databases

BgeeiP15037.
CleanExiMM_ETS2.
ExpressionAtlasiP15037. baseline and differential.
GenevestigatoriP15037.

Interactioni

Protein-protein interaction databases

BioGridi204766. 6 interactions.
DIPiDIP-41847N.
MINTiMINT-194890.
STRINGi10090.ENSMUSP00000023612.

Structurei

3D structure databases

ProteinModelPortaliP15037.
SMRiP15037. Positions 76-170, 328-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 17086PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG305402.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15037.
KOiK02678.
OMAiFGMNGQV.
OrthoDBiEOG77127T.
PhylomeDBiP15037.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15037-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ
60 70 80 90 100
EVPTGLDSVS HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP
110 120 130 140 150
KNPWLWSEQQ VCQWLLWATN EFSLVNVNLH QFGMNGQMLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLNAVPHW INSNTLGFSM
210 220 230 240 250
EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK SRLNTVNVNY
260 270 280 290 300
CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS
310 320 330 340 350
LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA
360 370 380 390 400
AVLAGFTGSG PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR
410 420 430 440 450
RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG
460
FTPEELHAIL GVQPDTED
Length:468
Mass (Da):52,827
Last modified:April 1, 1990 - v1
Checksum:i5260F3085B7EB831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04103 mRNA. Translation: AAA37581.1.
BC005504 mRNA. Translation: AAH05504.1.
CCDSiCCDS37412.1.
PIRiC32066. TVMSE2.
RefSeqiNP_035939.3. NM_011809.3.
UniGeneiMm.290207.

Genome annotation databases

EnsembliENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895.
GeneIDi23872.
KEGGimmu:23872.
UCSCiuc008ace.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04103 mRNA. Translation: AAA37581.1 .
BC005504 mRNA. Translation: AAH05504.1 .
CCDSi CCDS37412.1.
PIRi C32066. TVMSE2.
RefSeqi NP_035939.3. NM_011809.3.
UniGenei Mm.290207.

3D structure databases

ProteinModelPortali P15037.
SMRi P15037. Positions 76-170, 328-459.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204766. 6 interactions.
DIPi DIP-41847N.
MINTi MINT-194890.
STRINGi 10090.ENSMUSP00000023612.

PTM databases

PhosphoSitei P15037.

Proteomic databases

MaxQBi P15037.
PRIDEi P15037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023612 ; ENSMUSP00000023612 ; ENSMUSG00000022895 .
GeneIDi 23872.
KEGGi mmu:23872.
UCSCi uc008ace.2. mouse.

Organism-specific databases

CTDi 2114.
MGIi MGI:95456. Ets2.

Phylogenomic databases

eggNOGi NOG305402.
HOGENOMi HOG000285953.
HOVERGENi HBG003088.
InParanoidi P15037.
KOi K02678.
OMAi FGMNGQV.
OrthoDBi EOG77127T.
PhylomeDBi P15037.
TreeFami TF316214.

Enzyme and pathway databases

Reactomei REACT_188971. Oncogene Induced Senescence.

Miscellaneous databases

ChiTaRSi Ets2. mouse.
NextBioi 303583.
PROi P15037.
SOURCEi Search...

Gene expression databases

Bgeei P15037.
CleanExi MM_ETS2.
ExpressionAtlasi P15037. baseline and differential.
Genevestigatori P15037.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiETS2_MOUSE
AccessioniPrimary (citable) accession number: P15037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 26, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3