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Protein

Protein C-ets-2

Gene

Ets2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi362 – 44281ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding Source: MGI
  5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central
  6. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: GO_Central
  2. mesoderm development Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  4. positive regulation of transcription, DNA-templated Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. primitive streak formation Source: MGI
  7. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  8. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_188971. Oncogene Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:Ets2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:95456. Ets2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Protein C-ets-2PRO_0000204078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei225 – 2251PhosphoserineBy similarity
Modified residuei294 – 2941PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15037.
PRIDEiP15037.

PTM databases

PhosphoSiteiP15037.

Expressioni

Gene expression databases

BgeeiP15037.
CleanExiMM_ETS2.
ExpressionAtlasiP15037. baseline and differential.
GenevestigatoriP15037.

Interactioni

Protein-protein interaction databases

BioGridi204766. 6 interactions.
DIPiDIP-41847N.
MINTiMINT-194890.
STRINGi10090.ENSMUSP00000023612.

Structurei

3D structure databases

ProteinModelPortaliP15037.
SMRiP15037. Positions 76-170, 328-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 17086PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG305402.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15037.
KOiK02678.
OMAiFGMNGQV.
OrthoDBiEOG77127T.
PhylomeDBiP15037.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ
60 70 80 90 100
EVPTGLDSVS HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP
110 120 130 140 150
KNPWLWSEQQ VCQWLLWATN EFSLVNVNLH QFGMNGQMLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLNAVPHW INSNTLGFSM
210 220 230 240 250
EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK SRLNTVNVNY
260 270 280 290 300
CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS
310 320 330 340 350
LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA
360 370 380 390 400
AVLAGFTGSG PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR
410 420 430 440 450
RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG
460
FTPEELHAIL GVQPDTED
Length:468
Mass (Da):52,827
Last modified:April 1, 1990 - v1
Checksum:i5260F3085B7EB831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04103 mRNA. Translation: AAA37581.1.
BC005504 mRNA. Translation: AAH05504.1.
CCDSiCCDS37412.1.
PIRiC32066. TVMSE2.
RefSeqiNP_035939.3. NM_011809.3.
UniGeneiMm.290207.

Genome annotation databases

EnsembliENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895.
GeneIDi23872.
KEGGimmu:23872.
UCSCiuc008ace.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04103 mRNA. Translation: AAA37581.1.
BC005504 mRNA. Translation: AAH05504.1.
CCDSiCCDS37412.1.
PIRiC32066. TVMSE2.
RefSeqiNP_035939.3. NM_011809.3.
UniGeneiMm.290207.

3D structure databases

ProteinModelPortaliP15037.
SMRiP15037. Positions 76-170, 328-459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204766. 6 interactions.
DIPiDIP-41847N.
MINTiMINT-194890.
STRINGi10090.ENSMUSP00000023612.

PTM databases

PhosphoSiteiP15037.

Proteomic databases

MaxQBiP15037.
PRIDEiP15037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895.
GeneIDi23872.
KEGGimmu:23872.
UCSCiuc008ace.2. mouse.

Organism-specific databases

CTDi2114.
MGIiMGI:95456. Ets2.

Phylogenomic databases

eggNOGiNOG305402.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15037.
KOiK02678.
OMAiFGMNGQV.
OrthoDBiEOG77127T.
PhylomeDBiP15037.
TreeFamiTF316214.

Enzyme and pathway databases

ReactomeiREACT_188971. Oncogene Induced Senescence.

Miscellaneous databases

ChiTaRSiEts2. mouse.
NextBioi303583.
PROiP15037.
SOURCEiSearch...

Gene expression databases

BgeeiP15037.
CleanExiMM_ETS2.
ExpressionAtlasiP15037. baseline and differential.
GenevestigatoriP15037.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiETS2_MOUSE
AccessioniPrimary (citable) accession number: P15037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: March 4, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.