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P15037 (ETS2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein C-ets-2
Gene names
Name:Ets2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes By similarity.

Subcellular location

Nucleus.

Post-translational modification

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation By similarity.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Contains 1 PNT (pointed) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Protein C-ets-2
PRO_0000204078

Regions

Domain85 – 17086PNT
DNA binding362 – 44281ETS

Amino acid modifications

Modified residue2201Phosphoserine By similarity
Modified residue2251Phosphoserine By similarity
Modified residue2941Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P15037 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 5260F3085B7EB831

FASTA46852,827
        10         20         30         40         50         60 
MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVL PSLSEDQTLQ EVPTGLDSVS 

        70         80         90        100        110        120 
HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP KNPWLWSEQQ VCQWLLWATN 

       130        140        150        160        170        180 
EFSLVNVNLH QFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE 

       190        200        210        220        230        240 
NSHLNAVPHW INSNTLGFSM EQAPYGMQAP NYPKDNLLDS MCPPSATPAA LGSELQMLPK 

       250        260        270        280        290        300 
SRLNTVNVNY CSISQDFPSS NVNLLNNNSG KPKDHDSPEN GGDSFESSDS LLRSWNSQSS 

       310        320        330        340        350        360 
LLDVQRVPSF ESFEEDCSQS LCLSKLTMSF KDYIQERSDP VEQGKPVIPA AVLAGFTGSG 

       370        380        390        400        410        420 
PIQLWQFLLE LLSDKSCQSF ISWTGDGWEF KLADPDEVAR RWGKRKNKPK MNYEKLSRGL 

       430        440        450        460 
RYYYDKNIIH KTSGKRYVYR FVCDLQNLLG FTPEELHAIL GVQPDTED 

« Hide

References

« Hide 'large scale' references
[1]"Mammalian ets-1 and ets-2 genes encode highly conserved proteins."
Watson D.K., McWilliams M.J., Lapis P., Lautenberger J.A., Schweinfest C.W., Papas T.S.
Proc. Natl. Acad. Sci. U.S.A. 85:7862-7866(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04103 mRNA. Translation: AAA37581.1.
BC005504 mRNA. Translation: AAH05504.1.
CCDSCCDS37412.1.
PIRTVMSE2. C32066.
RefSeqNP_035939.3. NM_011809.3.
UniGeneMm.290207.

3D structure databases

ProteinModelPortalP15037.
SMRP15037. Positions 76-170, 328-459.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204766. 5 interactions.
DIPDIP-41847N.
MINTMINT-194890.
STRING10090.ENSMUSP00000023612.

PTM databases

PhosphoSiteP15037.

Proteomic databases

PRIDEP15037.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023612; ENSMUSP00000023612; ENSMUSG00000022895.
GeneID23872.
KEGGmmu:23872.
UCSCuc008ace.2. mouse.

Organism-specific databases

CTD2114.
MGIMGI:95456. Ets2.

Phylogenomic databases

eggNOGNOG305402.
HOGENOMHOG000285953.
HOVERGENHBG003088.
InParanoidP15037.
KOK02678.
OMAFGMNGQV.
OrthoDBEOG77127T.
PhylomeDBP15037.
TreeFamTF316214.

Gene expression databases

ArrayExpressP15037.
BgeeP15037.
CleanExMM_ETS2.
GenevestigatorP15037.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSETS2. mouse.
NextBio303583.
PROP15037.
SOURCESearch...

Entry information

Entry nameETS2_MOUSE
AccessionPrimary (citable) accession number: P15037
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot