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Protein

Protein C-ets-2

Gene

ETS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi363 – 443ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157557-MONOMER.
ReactomeiR-HSA-2559585. Oncogene Induced Senescence.
SignaLinkiP15036.
SIGNORiP15036.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:ETS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:3489. ETS2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2114.
OpenTargetsiENSG00000157557.
PharmGKBiPA27903.

Polymorphism and mutation databases

BioMutaiETS2.
DMDMi119645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040771 – 469Protein C-ets-2Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei220Phosphoserine1 Publication1
Modified residuei225Phosphoserine1 Publication1
Modified residuei295PhosphoserineCombined sources1
Modified residuei298PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15036.
PaxDbiP15036.
PeptideAtlasiP15036.
PRIDEiP15036.

PTM databases

iPTMnetiP15036.
PhosphoSitePlusiP15036.

Expressioni

Gene expression databases

BgeeiENSG00000157557.
CleanExiHS_ETS2.
ExpressionAtlasiP15036. baseline and differential.
GenevisibleiP15036. HS.

Organism-specific databases

HPAiHPA003176.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK10Q151312EBI-1646991,EBI-1646959
CDK10Q15131-13EBI-1646991,EBI-11507283
RFWD2Q8NHY22EBI-1646991,EBI-1176214
TWIST1Q156722EBI-1646991,EBI-1797287
TWIST2Q8WVJ92EBI-1646991,EBI-1797313

Protein-protein interaction databases

BioGridi108415. 29 interactors.
DIPiDIP-40452N.
IntActiP15036. 21 interactors.
MINTiMINT-132932.
STRINGi9606.ENSP00000353344.

Structurei

Secondary structure

1469
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi78 – 84Combined sources7
Helixi85 – 89Combined sources5
Helixi90 – 96Combined sources7
Helixi103 – 105Combined sources3
Helixi108 – 121Combined sources14
Helixi129 – 132Combined sources4
Helixi136 – 141Combined sources6
Helixi144 – 150Combined sources7
Helixi155 – 169Combined sources15
Helixi331 – 334Combined sources4
Helixi335 – 337Combined sources3
Beta strandi338 – 342Combined sources5
Beta strandi344 – 346Combined sources3
Helixi351 – 358Combined sources8
Helixi365 – 373Combined sources9
Helixi376 – 378Combined sources3
Turni379 – 381Combined sources3
Beta strandi382 – 384Combined sources3
Beta strandi390 – 392Combined sources3
Helixi396 – 407Combined sources12
Helixi414 – 422Combined sources9
Turni423 – 428Combined sources6
Beta strandi429 – 432Combined sources4
Beta strandi439 – 442Combined sources4
Helixi446 – 450Combined sources5
Helixi454 – 457Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BQAX-ray2.50A/D/G325-464[»]
4MHVX-ray2.45A/B76-170[»]
ProteinModelPortaliP15036.
SMRiP15036.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 170PNTPROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15036.
KOiK02678.
OMAiFGMNGQV.
OrthoDBiEOG091G0HJF.
PhylomeDBiP15036.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ
60 70 80 90 100
EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP
110 120 130 140 150
KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL
160 170 180 190 200
APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT
210 220 230 240 250
EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT
260 270 280 290 300
YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS
310 320 330 340 350
SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP
360 370 380 390 400
AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA
410 420 430 440 450
RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL
460
GFTPEELHAI LGVQPDTED
Length:469
Mass (Da):53,001
Last modified:April 1, 1990 - v1
Checksum:i5944EC4B5AAB553E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04102 mRNA. Translation: AAA52412.1.
AF017257 Genomic DNA. Translation: AAB94057.1.
AK315563 mRNA. Translation: BAG37939.1.
BT006838 mRNA. Translation: AAP35484.1.
AL163278 Genomic DNA. Translation: CAB90468.1.
AP001732 Genomic DNA. Translation: BAA95514.1.
AP001040 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09673.1.
CH471079 Genomic DNA. Translation: EAX09674.1.
CH471079 Genomic DNA. Translation: EAX09676.1.
BC017040 mRNA. Translation: AAH17040.1.
BC042954 mRNA. Translation: AAH42954.1.
X55181 Genomic DNA. Translation: CAA38966.1.
M11922 mRNA. Translation: AAA52411.1.
CCDSiCCDS13659.1.
PIRiB32066. TVHUE2.
RefSeqiNP_005230.1. NM_005239.5.
XP_005260992.1. XM_005260935.1.
XP_016883779.1. XM_017028290.1.
UniGeneiHs.644231.

Genome annotation databases

EnsembliENST00000360214; ENSP00000353344; ENSG00000157557.
ENST00000360938; ENSP00000354194; ENSG00000157557.
GeneIDi2114.
KEGGihsa:2114.
UCSCiuc002yxf.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04102 mRNA. Translation: AAA52412.1.
AF017257 Genomic DNA. Translation: AAB94057.1.
AK315563 mRNA. Translation: BAG37939.1.
BT006838 mRNA. Translation: AAP35484.1.
AL163278 Genomic DNA. Translation: CAB90468.1.
AP001732 Genomic DNA. Translation: BAA95514.1.
AP001040 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09673.1.
CH471079 Genomic DNA. Translation: EAX09674.1.
CH471079 Genomic DNA. Translation: EAX09676.1.
BC017040 mRNA. Translation: AAH17040.1.
BC042954 mRNA. Translation: AAH42954.1.
X55181 Genomic DNA. Translation: CAA38966.1.
M11922 mRNA. Translation: AAA52411.1.
CCDSiCCDS13659.1.
PIRiB32066. TVHUE2.
RefSeqiNP_005230.1. NM_005239.5.
XP_005260992.1. XM_005260935.1.
XP_016883779.1. XM_017028290.1.
UniGeneiHs.644231.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BQAX-ray2.50A/D/G325-464[»]
4MHVX-ray2.45A/B76-170[»]
ProteinModelPortaliP15036.
SMRiP15036.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108415. 29 interactors.
DIPiDIP-40452N.
IntActiP15036. 21 interactors.
MINTiMINT-132932.
STRINGi9606.ENSP00000353344.

PTM databases

iPTMnetiP15036.
PhosphoSitePlusiP15036.

Polymorphism and mutation databases

BioMutaiETS2.
DMDMi119645.

Proteomic databases

MaxQBiP15036.
PaxDbiP15036.
PeptideAtlasiP15036.
PRIDEiP15036.

Protocols and materials databases

DNASUi2114.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360214; ENSP00000353344; ENSG00000157557.
ENST00000360938; ENSP00000354194; ENSG00000157557.
GeneIDi2114.
KEGGihsa:2114.
UCSCiuc002yxf.4. human.

Organism-specific databases

CTDi2114.
DisGeNETi2114.
GeneCardsiETS2.
HGNCiHGNC:3489. ETS2.
HPAiHPA003176.
MIMi164740. gene.
neXtProtiNX_P15036.
OpenTargetsiENSG00000157557.
PharmGKBiPA27903.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3806. Eukaryota.
ENOG410Z0ZF. LUCA.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15036.
KOiK02678.
OMAiFGMNGQV.
OrthoDBiEOG091G0HJF.
PhylomeDBiP15036.
TreeFamiTF316214.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157557-MONOMER.
ReactomeiR-HSA-2559585. Oncogene Induced Senescence.
SignaLinkiP15036.
SIGNORiP15036.

Miscellaneous databases

ChiTaRSiETS2. human.
GeneWikiiETS2.
GenomeRNAii2114.
PROiP15036.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157557.
CleanExiHS_ETS2.
ExpressionAtlasiP15036. baseline and differential.
GenevisibleiP15036. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETS2_HUMAN
AccessioniPrimary (citable) accession number: P15036
Secondary accession number(s): A6NM68, D3DSH6, Q53Y89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.