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P15036

- ETS2_HUMAN

UniProt

P15036 - ETS2_HUMAN

Protein

Protein C-ets-2

Gene

ETS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi363 – 44381ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. protein binding Source: IntAct
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    6. sequence-specific DNA binding transcription factor activity Source: BHF-UCL

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    3. positive regulation of transcription, DNA-templated Source: BHF-UCL
    4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    5. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    6. skeletal system development Source: ProtInc
    7. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_169325. Oncogene Induced Senescence.
    SignaLinkiP15036.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein C-ets-2
    Gene namesi
    Name:ETS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:3489. ETS2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA27903.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Protein C-ets-2PRO_0000204077Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei220 – 2201Phosphoserine1 Publication
    Modified residuei225 – 2251Phosphoserine1 Publication
    Modified residuei295 – 2951Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP15036.
    PaxDbiP15036.
    PRIDEiP15036.

    PTM databases

    PhosphoSiteiP15036.

    Expressioni

    Gene expression databases

    ArrayExpressiP15036.
    BgeeiP15036.
    CleanExiHS_ETS2.
    GenevestigatoriP15036.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK10Q151312EBI-1646991,EBI-1646959
    TWIST1Q156722EBI-1646991,EBI-1797287
    TWIST2Q8WVJ92EBI-1646991,EBI-1797313

    Protein-protein interaction databases

    BioGridi108415. 22 interactions.
    IntActiP15036. 12 interactions.
    MINTiMINT-132932.
    STRINGi9606.ENSP00000353344.

    Structurei

    Secondary structure

    1
    469
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi78 – 847
    Helixi85 – 895
    Helixi90 – 967
    Helixi103 – 1053
    Helixi108 – 12114
    Helixi129 – 1324
    Helixi136 – 1416
    Helixi144 – 1507
    Helixi155 – 16915
    Helixi331 – 3344
    Helixi335 – 3373
    Beta strandi338 – 3425
    Beta strandi344 – 3463
    Helixi351 – 3588
    Helixi365 – 3739
    Helixi376 – 3783
    Turni379 – 3813
    Beta strandi382 – 3843
    Beta strandi390 – 3923
    Helixi396 – 40712
    Helixi414 – 4229
    Turni423 – 4286
    Beta strandi429 – 4324
    Beta strandi439 – 4424
    Helixi446 – 4505
    Helixi454 – 4574

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BQAX-ray2.50A/D/G325-464[»]
    4MHVX-ray2.45A/B76-170[»]
    ProteinModelPortaliP15036.
    SMRiP15036. Positions 76-170, 329-460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 17086PNTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG305402.
    HOGENOMiHOG000285953.
    HOVERGENiHBG003088.
    InParanoidiP15036.
    KOiK02678.
    OMAiFGMNGQV.
    OrthoDBiEOG77127T.
    PhylomeDBiP15036.
    TreeFamiTF316214.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016311. Transform_prot_C-ets.
    IPR027276. Transform_prot_C-ets-2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF501032. C-ets-2. 1 hit.
    PIRSF001698. Transforming_factor_C-ets. 1 hit.
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15036-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ    50
    EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP 100
    KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL 150
    APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT 200
    EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT 250
    YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS 300
    SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP 350
    AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA 400
    RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL 450
    GFTPEELHAI LGVQPDTED 469
    Length:469
    Mass (Da):53,001
    Last modified:April 1, 1990 - v1
    Checksum:i5944EC4B5AAB553E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04102 mRNA. Translation: AAA52412.1.
    AF017257 Genomic DNA. Translation: AAB94057.1.
    AK315563 mRNA. Translation: BAG37939.1.
    BT006838 mRNA. Translation: AAP35484.1.
    AL163278 Genomic DNA. Translation: CAB90468.1.
    AP001732 Genomic DNA. Translation: BAA95514.1.
    AP001040 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09673.1.
    CH471079 Genomic DNA. Translation: EAX09674.1.
    CH471079 Genomic DNA. Translation: EAX09676.1.
    BC017040 mRNA. Translation: AAH17040.1.
    BC042954 mRNA. Translation: AAH42954.1.
    X55181 Genomic DNA. Translation: CAA38966.1.
    M11922 mRNA. Translation: AAA52411.1.
    CCDSiCCDS13659.1.
    PIRiB32066. TVHUE2.
    RefSeqiNP_005230.1. NM_005239.5.
    XP_005260992.1. XM_005260935.1.
    UniGeneiHs.644231.

    Genome annotation databases

    EnsembliENST00000360214; ENSP00000353344; ENSG00000157557.
    ENST00000360938; ENSP00000354194; ENSG00000157557.
    ENST00000432278; ENSP00000401273; ENSG00000157557.
    GeneIDi2114.
    KEGGihsa:2114.
    UCSCiuc002yxf.3. human.

    Polymorphism databases

    DMDMi119645.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04102 mRNA. Translation: AAA52412.1 .
    AF017257 Genomic DNA. Translation: AAB94057.1 .
    AK315563 mRNA. Translation: BAG37939.1 .
    BT006838 mRNA. Translation: AAP35484.1 .
    AL163278 Genomic DNA. Translation: CAB90468.1 .
    AP001732 Genomic DNA. Translation: BAA95514.1 .
    AP001040 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09673.1 .
    CH471079 Genomic DNA. Translation: EAX09674.1 .
    CH471079 Genomic DNA. Translation: EAX09676.1 .
    BC017040 mRNA. Translation: AAH17040.1 .
    BC042954 mRNA. Translation: AAH42954.1 .
    X55181 Genomic DNA. Translation: CAA38966.1 .
    M11922 mRNA. Translation: AAA52411.1 .
    CCDSi CCDS13659.1.
    PIRi B32066. TVHUE2.
    RefSeqi NP_005230.1. NM_005239.5.
    XP_005260992.1. XM_005260935.1.
    UniGenei Hs.644231.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BQA X-ray 2.50 A/D/G 325-464 [» ]
    4MHV X-ray 2.45 A/B 76-170 [» ]
    ProteinModelPortali P15036.
    SMRi P15036. Positions 76-170, 329-460.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108415. 22 interactions.
    IntActi P15036. 12 interactions.
    MINTi MINT-132932.
    STRINGi 9606.ENSP00000353344.

    PTM databases

    PhosphoSitei P15036.

    Polymorphism databases

    DMDMi 119645.

    Proteomic databases

    MaxQBi P15036.
    PaxDbi P15036.
    PRIDEi P15036.

    Protocols and materials databases

    DNASUi 2114.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360214 ; ENSP00000353344 ; ENSG00000157557 .
    ENST00000360938 ; ENSP00000354194 ; ENSG00000157557 .
    ENST00000432278 ; ENSP00000401273 ; ENSG00000157557 .
    GeneIDi 2114.
    KEGGi hsa:2114.
    UCSCi uc002yxf.3. human.

    Organism-specific databases

    CTDi 2114.
    GeneCardsi GC21P040177.
    HGNCi HGNC:3489. ETS2.
    MIMi 164740. gene.
    neXtProti NX_P15036.
    PharmGKBi PA27903.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305402.
    HOGENOMi HOG000285953.
    HOVERGENi HBG003088.
    InParanoidi P15036.
    KOi K02678.
    OMAi FGMNGQV.
    OrthoDBi EOG77127T.
    PhylomeDBi P15036.
    TreeFami TF316214.

    Enzyme and pathway databases

    Reactomei REACT_169325. Oncogene Induced Senescence.
    SignaLinki P15036.

    Miscellaneous databases

    ChiTaRSi ETS2. human.
    GeneWikii ETS2.
    GenomeRNAii 2114.
    NextBioi 8543.
    PROi P15036.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15036.
    Bgeei P15036.
    CleanExi HS_ETS2.
    Genevestigatori P15036.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR016311. Transform_prot_C-ets.
    IPR027276. Transform_prot_C-ets-2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF501032. C-ets-2. 1 hit.
    PIRSF001698. Transforming_factor_C-ets. 1 hit.
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Zimmermann W.W.K., Korenberg J., Rosenthal A., Schattevoy R.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Colon.
    8. "Molecular organization and differential polyadenylation sites of the human ETS2 gene."
      Watson D.K., Mavrothalassitis G.J., Jorcyk C.L., Smyth F.E., Papas T.S.
      Oncogene 5:1521-1527(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 399-469.
    9. "The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active."
      Watson D.K., McWilliams-Smith M.J., Nunn M.F., Duesberg P.H., O'Brien S.J., Papas T.S.
      Proc. Natl. Acad. Sci. U.S.A. 82:7294-7298(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-469.
    10. "Sp100 interacts with ETS-1 and stimulates its transcriptional activity."
      Wasylyk C., Schlumberger S.E., Criqui-Filipe P., Wasylyk B.
      Mol. Cell. Biol. 22:2687-2702(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR.
    11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."
      Guen V.J., Gamble C., Flajolet M., Unger S., Thollet A., Ferandin Y., Superti-Furga A., Cohen P.A., Meijer L., Colas P.
      Proc. Natl. Acad. Sci. U.S.A. 110:19525-19530(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-220 AND SER-225.

    Entry informationi

    Entry nameiETS2_HUMAN
    AccessioniPrimary (citable) accession number: P15036
    Secondary accession number(s): A6NM68, D3DSH6, Q53Y89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 149 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3