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P15036

- ETS2_HUMAN

UniProt

P15036 - ETS2_HUMAN

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Protein
Protein C-ets-2
Gene
ETS2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi363 – 44381ETS
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  5. sequence-specific DNA binding transcription factor activity Source: BHF-UCL

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. positive regulation of transcription, DNA-templated Source: BHF-UCL
  4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  5. skeletal system development Source: ProtInc
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_169325. Oncogene Induced Senescence.
SignaLinkiP15036.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein C-ets-2
Gene namesi
Name:ETS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:3489. ETS2.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA27903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Protein C-ets-2
PRO_0000204077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201Phosphoserine1 Publication
Modified residuei225 – 2251Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15036.
PaxDbiP15036.
PRIDEiP15036.

PTM databases

PhosphoSiteiP15036.

Expressioni

Gene expression databases

ArrayExpressiP15036.
BgeeiP15036.
CleanExiHS_ETS2.
GenevestigatoriP15036.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK10Q151312EBI-1646991,EBI-1646959
TWIST1Q156722EBI-1646991,EBI-1797287
TWIST2Q8WVJ92EBI-1646991,EBI-1797313

Protein-protein interaction databases

BioGridi108415. 22 interactions.
IntActiP15036. 12 interactions.
MINTiMINT-132932.
STRINGi9606.ENSP00000353344.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi78 – 847
Helixi85 – 895
Helixi90 – 967
Helixi103 – 1053
Helixi108 – 12114
Helixi129 – 1324
Helixi136 – 1416
Helixi144 – 1507
Helixi155 – 16915
Helixi331 – 3344
Helixi335 – 3373
Beta strandi338 – 3425
Beta strandi344 – 3463
Helixi351 – 3588
Helixi365 – 3739
Helixi376 – 3783
Turni379 – 3813
Beta strandi382 – 3843
Beta strandi390 – 3923
Helixi396 – 40712
Helixi414 – 4229
Turni423 – 4286
Beta strandi429 – 4324
Beta strandi439 – 4424
Helixi446 – 4505
Helixi454 – 4574

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BQAX-ray2.50A/D/G325-464[»]
4MHVX-ray2.45A/B76-170[»]
ProteinModelPortaliP15036.
SMRiP15036. Positions 76-170, 329-460.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 17086PNT
Add
BLAST

Sequence similaritiesi

Belongs to the ETS family.

Phylogenomic databases

eggNOGiNOG305402.
HOGENOMiHOG000285953.
HOVERGENiHBG003088.
InParanoidiP15036.
KOiK02678.
OMAiFGMNGQV.
OrthoDBiEOG77127T.
PhylomeDBiP15036.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15036-1 [UniParc]FASTAAdd to Basket

« Hide

MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ    50
EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP 100
KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL 150
APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT 200
EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT 250
YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS 300
SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP 350
AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA 400
RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL 450
GFTPEELHAI LGVQPDTED 469
Length:469
Mass (Da):53,001
Last modified:April 1, 1990 - v1
Checksum:i5944EC4B5AAB553E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04102 mRNA. Translation: AAA52412.1.
AF017257 Genomic DNA. Translation: AAB94057.1.
AK315563 mRNA. Translation: BAG37939.1.
BT006838 mRNA. Translation: AAP35484.1.
AL163278 Genomic DNA. Translation: CAB90468.1.
AP001732 Genomic DNA. Translation: BAA95514.1.
AP001040 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09673.1.
CH471079 Genomic DNA. Translation: EAX09674.1.
CH471079 Genomic DNA. Translation: EAX09676.1.
BC017040 mRNA. Translation: AAH17040.1.
BC042954 mRNA. Translation: AAH42954.1.
X55181 Genomic DNA. Translation: CAA38966.1.
M11922 mRNA. Translation: AAA52411.1.
CCDSiCCDS13659.1.
PIRiB32066. TVHUE2.
RefSeqiNP_005230.1. NM_005239.5.
XP_005260992.1. XM_005260935.1.
UniGeneiHs.644231.

Genome annotation databases

EnsembliENST00000360214; ENSP00000353344; ENSG00000157557.
ENST00000360938; ENSP00000354194; ENSG00000157557.
ENST00000432278; ENSP00000401273; ENSG00000157557.
GeneIDi2114.
KEGGihsa:2114.
UCSCiuc002yxf.3. human.

Polymorphism databases

DMDMi119645.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04102 mRNA. Translation: AAA52412.1 .
AF017257 Genomic DNA. Translation: AAB94057.1 .
AK315563 mRNA. Translation: BAG37939.1 .
BT006838 mRNA. Translation: AAP35484.1 .
AL163278 Genomic DNA. Translation: CAB90468.1 .
AP001732 Genomic DNA. Translation: BAA95514.1 .
AP001040 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09673.1 .
CH471079 Genomic DNA. Translation: EAX09674.1 .
CH471079 Genomic DNA. Translation: EAX09676.1 .
BC017040 mRNA. Translation: AAH17040.1 .
BC042954 mRNA. Translation: AAH42954.1 .
X55181 Genomic DNA. Translation: CAA38966.1 .
M11922 mRNA. Translation: AAA52411.1 .
CCDSi CCDS13659.1.
PIRi B32066. TVHUE2.
RefSeqi NP_005230.1. NM_005239.5.
XP_005260992.1. XM_005260935.1.
UniGenei Hs.644231.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BQA X-ray 2.50 A/D/G 325-464 [» ]
4MHV X-ray 2.45 A/B 76-170 [» ]
ProteinModelPortali P15036.
SMRi P15036. Positions 76-170, 329-460.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108415. 22 interactions.
IntActi P15036. 12 interactions.
MINTi MINT-132932.
STRINGi 9606.ENSP00000353344.

PTM databases

PhosphoSitei P15036.

Polymorphism databases

DMDMi 119645.

Proteomic databases

MaxQBi P15036.
PaxDbi P15036.
PRIDEi P15036.

Protocols and materials databases

DNASUi 2114.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360214 ; ENSP00000353344 ; ENSG00000157557 .
ENST00000360938 ; ENSP00000354194 ; ENSG00000157557 .
ENST00000432278 ; ENSP00000401273 ; ENSG00000157557 .
GeneIDi 2114.
KEGGi hsa:2114.
UCSCi uc002yxf.3. human.

Organism-specific databases

CTDi 2114.
GeneCardsi GC21P040177.
HGNCi HGNC:3489. ETS2.
MIMi 164740. gene.
neXtProti NX_P15036.
PharmGKBi PA27903.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG305402.
HOGENOMi HOG000285953.
HOVERGENi HBG003088.
InParanoidi P15036.
KOi K02678.
OMAi FGMNGQV.
OrthoDBi EOG77127T.
PhylomeDBi P15036.
TreeFami TF316214.

Enzyme and pathway databases

Reactomei REACT_169325. Oncogene Induced Senescence.
SignaLinki P15036.

Miscellaneous databases

ChiTaRSi ETS2. human.
GeneWikii ETS2.
GenomeRNAii 2114.
NextBioi 8543.
PROi P15036.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15036.
Bgeei P15036.
CleanExi HS_ETS2.
Genevestigatori P15036.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016311. Transform_prot_C-ets.
IPR027276. Transform_prot_C-ets-2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF501032. C-ets-2. 1 hit.
PIRSF001698. Transforming_factor_C-ets. 1 hit.
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Zimmermann W.W.K., Korenberg J., Rosenthal A., Schattevoy R.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Colon.
  8. "Molecular organization and differential polyadenylation sites of the human ETS2 gene."
    Watson D.K., Mavrothalassitis G.J., Jorcyk C.L., Smyth F.E., Papas T.S.
    Oncogene 5:1521-1527(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 399-469.
  9. "The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active."
    Watson D.K., McWilliams-Smith M.J., Nunn M.F., Duesberg P.H., O'Brien S.J., Papas T.S.
    Proc. Natl. Acad. Sci. U.S.A. 82:7294-7298(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-469.
  10. "Sp100 interacts with ETS-1 and stimulates its transcriptional activity."
    Wasylyk C., Schlumberger S.E., Criqui-Filipe P., Wasylyk B.
    Mol. Cell. Biol. 22:2687-2702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A TRANSCRIPTIONAL ACTIVATOR.
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome."
    Guen V.J., Gamble C., Flajolet M., Unger S., Thollet A., Ferandin Y., Superti-Furga A., Cohen P.A., Meijer L., Colas P.
    Proc. Natl. Acad. Sci. U.S.A. 110:19525-19530(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-220 AND SER-225.

Entry informationi

Entry nameiETS2_HUMAN
AccessioniPrimary (citable) accession number: P15036
Secondary accession number(s): A6NM68, D3DSH6, Q53Y89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 3, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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