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Protein

Fe(3+) dicitrate transport system permease protein FecC

Gene

fecC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:FECC-MONOMER.
ECOL316407:JW4249-MONOMER.
MetaCyc:FECC-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+) dicitrate transport system permease protein FecC
Alternative name(s):
Iron(III) dicitrate transport system permease protein FecC
Gene namesi
Name:fecC
Ordered Locus Names:b4289, JW4249
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10288. fecC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 64PeriplasmicSequence analysisAdd BLAST36
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 118CytoplasmicSequence analysisAdd BLAST33
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 152PeriplasmicSequence analysisAdd BLAST13
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 199CytoplasmicSequence analysisAdd BLAST26
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 244PeriplasmicSequence analysisAdd BLAST24
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 280CytoplasmicSequence analysisAdd BLAST15
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 307PeriplasmicSequence analysis6
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 332CytoplasmicSequence analysis4

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600201 – 332Fe(3+) dicitrate transport system permease protein FecCAdd BLAST332

Proteomic databases

PaxDbiP15030.
PRIDEiP15030.

Expressioni

Inductioni

Induced 1.8-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262741. 354 interactors.
STRINGi511145.b4289.

Structurei

3D structure databases

ProteinModelPortaliP15030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DQ5. Bacteria.
COG0609. LUCA.
HOGENOMiHOG000045410.
InParanoidiP15030.
KOiK02015.
OMAiMAHVRAL.
PhylomeDBiP15030.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_FecCD.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

P15030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIKHPVLL WGLPVAALII IFWLSLFCYS AIPVSGADAT RALLPGHTPT
60 70 80 90 100
LPEALVQNLR LPRSLVAVLI GASLALAGTL LQTLTHNPMA SPSLLGINSG
110 120 130 140 150
AALAMALTSA LSPTPIAGYS LSFIAACGGG VSWLLVMTAG GGFRHTHDRN
160 170 180 190 200
KLILAGIALS AFCMGLTRIT LLLAEDHAYG IFYWLAGGVS HARWQDVWQL
210 220 230 240 250
LPVVVTAVPV VLLLANQLNL LNLSDSTAHT LGVNLTRLRL VINMLVLLLV
260 270 280 290 300
GACVSVAGPV AFIGLLVPHL ARFWAGFDQR NVLPVSMLLG ATLMLLADVL
310 320 330
ARALAFPGDL PAGAVLALIG SPCFVWLVRR RG
Length:332
Mass (Da):34,893
Last modified:February 1, 1995 - v2
Checksum:i1BCE861FEE5E16DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103 – 123LAMAL…YSLSF → WLWRYQRAESDADCRLFSVV in AAA23763 (PubMed:2651410).CuratedAdd BLAST21
Sequence conflicti178A → AS in AAA23763 (PubMed:2651410).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26397 Genomic DNA. Translation: AAA23763.1.
U14003 Genomic DNA. Translation: AAA97185.1.
U00096 Genomic DNA. Translation: AAC77245.1.
AP009048 Genomic DNA. Translation: BAE78280.1.
PIRiS56514. QRECD1.
RefSeqiNP_418709.1. NC_000913.3.
WP_000125187.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77245; AAC77245; b4289.
BAE78280; BAE78280; BAE78280.
GeneIDi948826.
KEGGiecj:JW4249.
eco:b4289.
PATRICi32124157. VBIEscCol129921_4422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26397 Genomic DNA. Translation: AAA23763.1.
U14003 Genomic DNA. Translation: AAA97185.1.
U00096 Genomic DNA. Translation: AAC77245.1.
AP009048 Genomic DNA. Translation: BAE78280.1.
PIRiS56514. QRECD1.
RefSeqiNP_418709.1. NC_000913.3.
WP_000125187.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP15030.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262741. 354 interactors.
STRINGi511145.b4289.

Protein family/group databases

TCDBi3.A.1.14.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP15030.
PRIDEiP15030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77245; AAC77245; b4289.
BAE78280; BAE78280; BAE78280.
GeneIDi948826.
KEGGiecj:JW4249.
eco:b4289.
PATRICi32124157. VBIEscCol129921_4422.

Organism-specific databases

EchoBASEiEB0284.
EcoGeneiEG10288. fecC.

Phylogenomic databases

eggNOGiENOG4105DQ5. Bacteria.
COG0609. LUCA.
HOGENOMiHOG000045410.
InParanoidiP15030.
KOiK02015.
OMAiMAHVRAL.
PhylomeDBiP15030.

Enzyme and pathway databases

BioCyciEcoCyc:FECC-MONOMER.
ECOL316407:JW4249-MONOMER.
MetaCyc:FECC-MONOMER.

Miscellaneous databases

PROiP15030.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_FecCD.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFECC_ECOLI
AccessioniPrimary (citable) accession number: P15030
Secondary accession number(s): Q2M626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.