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Protein

Fe(3+) dicitrate transport system permease protein FecD

Gene

fecD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:FECD-MONOMER.
ECOL316407:JW4248-MONOMER.
MetaCyc:FECD-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+) dicitrate transport system permease protein FecD
Alternative name(s):
Iron(III) dicitrate transport system permease protein FecD
Gene namesi
Name:fecD
Ordered Locus Names:b4288, JW4248
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10289. fecD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22PeriplasmicSequence analysis
Transmembranei3 – 2321HelicalSequence analysisAdd
BLAST
Topological domaini24 – 5532CytoplasmicSequence analysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Topological domaini77 – 848PeriplasmicSequence analysis
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 13711PeriplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 17921CytoplasmicSequence analysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Topological domaini201 – 22525PeriplasmicSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 26923CytoplasmicSequence analysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Topological domaini291 – 2944PeriplasmicSequence analysis
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST
Topological domaini316 – 3183CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Fe(3+) dicitrate transport system permease protein FecDPRO_0000060021Add
BLAST

Proteomic databases

PaxDbiP15029.
PRIDEiP15029.

Expressioni

Inductioni

Induced 1.3-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262740. 321 interactions.
STRINGi511145.b4288.

Structurei

3D structure databases

ProteinModelPortaliP15029.
SMRiP15029. Positions 9-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108IHU. Bacteria.
COG0609. LUCA.
HOGENOMiHOG000045409.
InParanoidiP15029.
KOiK02015.
OMAiAPIEIPC.
OrthoDBiEOG61ZTDC.
PhylomeDBiP15029.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_permAse.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

P15029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIALVIFIT LALAGCALLS LHMGVIPVPW RALLTDWQAG HEHYYVLMEY
60 70 80 90 100
RLPRLLLALF VGAALAVAGV LIQGIVRNPL ASPDILGVNH AASLASVGAL
110 120 130 140 150
LLMPSLPVMV LPLLAFAGGM AGLILLKMLA KTHQPMKLAL TGVALSACWA
160 170 180 190 200
SLTDYLMLSR PQDVNNALLW LTGSLWGRDW SFVKIAIPLM ILFLPLSLSF
210 220 230 240 250
CRDLDLLALG DARATTLGVS VPHTRFWALL LAVAMTSTGV AACGPISFIG
260 270 280 290 300
LVVPHMMRSI TGGRHRRLLP VSALTGALLL VVADLLARII HPPLELPVGV
310
LTAIIGAPWF VWLLVRMR
Length:318
Mass (Da):34,131
Last modified:February 1, 1995 - v2
Checksum:i2C86FAD547904693
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411H → R in AAA23764 (PubMed:2651410).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26397 Genomic DNA. Translation: AAA23764.1.
U14003 Genomic DNA. Translation: AAA97184.1.
U00096 Genomic DNA. Translation: AAC77244.1.
AP009048 Genomic DNA. Translation: BAE78279.1.
PIRiS56513. QRECD2.
RefSeqiNP_418708.1. NC_000913.3.
WP_000684852.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77244; AAC77244; b4288.
BAE78279; BAE78279; BAE78279.
GeneIDi946816.
KEGGiecj:JW4248.
eco:b4288.
PATRICi32124155. VBIEscCol129921_4421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26397 Genomic DNA. Translation: AAA23764.1.
U14003 Genomic DNA. Translation: AAA97184.1.
U00096 Genomic DNA. Translation: AAC77244.1.
AP009048 Genomic DNA. Translation: BAE78279.1.
PIRiS56513. QRECD2.
RefSeqiNP_418708.1. NC_000913.3.
WP_000684852.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP15029.
SMRiP15029. Positions 9-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262740. 321 interactions.
STRINGi511145.b4288.

Protein family/group databases

TCDBi3.A.1.14.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP15029.
PRIDEiP15029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77244; AAC77244; b4288.
BAE78279; BAE78279; BAE78279.
GeneIDi946816.
KEGGiecj:JW4248.
eco:b4288.
PATRICi32124155. VBIEscCol129921_4421.

Organism-specific databases

EchoBASEiEB0285.
EcoGeneiEG10289. fecD.

Phylogenomic databases

eggNOGiENOG4108IHU. Bacteria.
COG0609. LUCA.
HOGENOMiHOG000045409.
InParanoidiP15029.
KOiK02015.
OMAiAPIEIPC.
OrthoDBiEOG61ZTDC.
PhylomeDBiP15029.

Enzyme and pathway databases

BioCyciEcoCyc:FECD-MONOMER.
ECOL316407:JW4248-MONOMER.
MetaCyc:FECD-MONOMER.

Miscellaneous databases

PROiP15029.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_permAse.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli."
    Staudenmaier H., van Hove B., Yaraghi Z., Braun V.
    J. Bacteriol. 171:2626-2633(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes."
    Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 23:2105-2119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  6. "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli."
    Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J., Walker G.C.
    Mol. Cell 36:845-860(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HYDROXYUREA.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Entry informationi

Entry nameiFECD_ECOLI
AccessioniPrimary (citable) accession number: P15029
Secondary accession number(s): Q2M627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1995
Last modified: January 20, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.