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Protein

Fe(3+) dicitrate transport system permease protein FecD

Gene

fecD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • iron chelate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • iron chelate transport Source: EcoCyc
  • iron ion homeostasis Source: UniProtKB-KW

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciEcoCyc:FECD-MONOMER.
MetaCyc:FECD-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+) dicitrate transport system permease protein FecD
Alternative name(s):
Iron(III) dicitrate transport system permease protein FecD
Gene namesi
Name:fecD
Ordered Locus Names:b4288, JW4248
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10289. fecD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2PeriplasmicSequence analysis2
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 55CytoplasmicSequence analysisAdd BLAST32
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 84PeriplasmicSequence analysis8
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 137PeriplasmicSequence analysisAdd BLAST11
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 179CytoplasmicSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 225PeriplasmicSequence analysisAdd BLAST25
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 269CytoplasmicSequence analysisAdd BLAST23
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 294PeriplasmicSequence analysis4
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 318CytoplasmicSequence analysis3

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600211 – 318Fe(3+) dicitrate transport system permease protein FecDAdd BLAST318

Proteomic databases

PaxDbiP15029.
PRIDEiP15029.

Expressioni

Inductioni

Induced 1.3-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262740. 321 interactors.
STRINGi316385.ECDH10B_4486.

Structurei

3D structure databases

ProteinModelPortaliP15029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108IHU. Bacteria.
COG0609. LUCA.
HOGENOMiHOG000045409.
InParanoidiP15029.
KOiK02015.
PhylomeDBiP15029.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiView protein in InterPro
IPR037294. ABC_BtuC-like.
IPR035568. ABC_transport_FecCD/TroCD-like.
IPR000522. ABC_transptr_FecCD.
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiView protein in Pfam
PF01032. FecCD. 1 hit.
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

P15029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIALVIFIT LALAGCALLS LHMGVIPVPW RALLTDWQAG HEHYYVLMEY
60 70 80 90 100
RLPRLLLALF VGAALAVAGV LIQGIVRNPL ASPDILGVNH AASLASVGAL
110 120 130 140 150
LLMPSLPVMV LPLLAFAGGM AGLILLKMLA KTHQPMKLAL TGVALSACWA
160 170 180 190 200
SLTDYLMLSR PQDVNNALLW LTGSLWGRDW SFVKIAIPLM ILFLPLSLSF
210 220 230 240 250
CRDLDLLALG DARATTLGVS VPHTRFWALL LAVAMTSTGV AACGPISFIG
260 270 280 290 300
LVVPHMMRSI TGGRHRRLLP VSALTGALLL VVADLLARII HPPLELPVGV
310
LTAIIGAPWF VWLLVRMR
Length:318
Mass (Da):34,131
Last modified:February 1, 1995 - v2
Checksum:i2C86FAD547904693
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41H → R in AAA23764 (PubMed:2651410).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26397 Genomic DNA. Translation: AAA23764.1.
U14003 Genomic DNA. Translation: AAA97184.1.
U00096 Genomic DNA. Translation: AAC77244.1.
AP009048 Genomic DNA. Translation: BAE78279.1.
PIRiS56513. QRECD2.
RefSeqiNP_418708.1. NC_000913.3.
WP_000684852.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77244; AAC77244; b4288.
BAE78279; BAE78279; BAE78279.
GeneIDi946816.
KEGGiecj:JW4248.
eco:b4288.
PATRICifig|1411691.4.peg.2411.

Similar proteinsi

Entry informationi

Entry nameiFECD_ECOLI
AccessioniPrimary (citable) accession number: P15029
Secondary accession number(s): Q2M627
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1995
Last modified: November 22, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families