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Protein

Fe(3+) dicitrate-binding periplasmic protein

Gene

fecB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds citrate-dependent Fe3+; part of the binding-protein-dependent transport system for uptake of citrate-dependent Fe3+.

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • iron chelate transport Source: EcoCyc
  • iron ion homeostasis Source: EcoCyc
  • response to iron ion Source: EcoCyc
  • transport Source: GO_Central

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciEcoCyc:FECB-MONOMER.
MetaCyc:FECB-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+) dicitrate-binding periplasmic protein
Alternative name(s):
Iron(III) dicitrate-binding periplasmic protein
Gene namesi
Name:fecB
Ordered Locus Names:b4290, JW4250
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10287. fecB.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003182022 – 300Fe(3+) dicitrate-binding periplasmic proteinAdd BLAST279

Proteomic databases

PaxDbiP15028.
PRIDEiP15028.

Expressioni

Inductioni

Induced 1.8-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261562. 211 interactors.
DIPiDIP-9584N.
IntActiP15028. 10 interactors.
MINTiMINT-1275090.
STRINGi316385.ECDH10B_4488.

Structurei

3D structure databases

ProteinModelPortaliP15028.
SMRiP15028.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 295Fe/B12 periplasmic-bindingPROSITE-ProRule annotationAdd BLAST257

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108HUF. Bacteria.
COG4594. LUCA.
HOGENOMiHOG000045521.
InParanoidiP15028.
KOiK02016.
PhylomeDBiP15028.

Family and domain databases

InterProiView protein in InterPro
IPR002491. ABC_transptr_periplasmic_BD.
PfamiView protein in Pfam
PF01497. Peripla_BP_2. 1 hit.
PROSITEiView protein in PROSITE
PS50983. FE_B12_PBP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAFIRFLFA GLLLVISHAF AATVQDEHGT FTLEKTPQRI VVLELSFADA
60 70 80 90 100
LAAVDVIPIG IADDNDAKRI LPEVRAHLKP WQSVGTRAQP SLEAIAALKP
110 120 130 140 150
DLIIADSSRH AGVYIALQQI APVLLLKSRN ETYAENLQSA AIIGEMVGKK
160 170 180 190 200
REMQARLEQH KERMAQWASQ LPKGTRVAFG TSREQQFNLH TQETWTGSVL
210 220 230 240 250
ASLGLNVPAA MAGASMPSIG LEQLLAVNPA WLLVAHYREE SIVKRWQQDP
260 270 280 290 300
LWQMLTAAQK QQVASVDSNT WARMRGIFAA ERIAADTVKI FHHQPLTVVK
Length:300
Mass (Da):33,146
Last modified:July 19, 2003 - v3
Checksum:i6024ED0F9C82D0EA
GO

Sequence cautioni

The sequence AAA97186 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → M in AAA23762 (PubMed:2651410).Curated1
Sequence conflicti57I → S in AAA23762 (PubMed:2651410).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti8L → V in strain: B. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26397 Genomic DNA. Translation: AAA23762.1.
U14003 Genomic DNA. Translation: AAA97186.1. Different initiation.
U00096 Genomic DNA. Translation: AAC77246.2.
AP009048 Genomic DNA. Translation: BAE78281.1.
PIRiS56515. QRECD3.
RefSeqiNP_418710.4. NC_000913.3.
WP_000879155.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77246; AAC77246; b4290.
BAE78281; BAE78281; BAE78281.
GeneIDi946838.
KEGGiecj:JW4250.
eco:b4290.
PATRICifig|1411691.4.peg.2409.

Similar proteinsi

Entry informationi

Entry nameiFECB_ECOLI
AccessioniPrimary (citable) accession number: P15028
Secondary accession number(s): P76816, Q2M625
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 19, 2003
Last modified: August 30, 2017
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families