Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

10 kDa chaperonin

Gene

groS

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa chaperonin
Alternative name(s):
GroES protein
Immunogenic protein MPB57
Protein Cpn10
Gene namesi
Name:groS
Synonyms:groES, mopB
Ordered Locus Names:Mb3452c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 1009910 kDa chaperoninPRO_0000174785Add
BLAST

Interactioni

Subunit structurei

Heptamer of 7 subunits arranged in a ring.By similarity

Structurei

3D structure databases

ProteinModelPortaliP15020.
SMRiP15020. Positions 2-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

HOGENOMiHOG000133897.
KOiK04078.
OMAiEHESCCH.
OrthoDBiEOG6GFGSD.

Family and domain databases

Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVNIKPLE DKILVQANEA ETTTASGLVI PDTAKEKPQE GTVVAVGPGR
60 70 80 90 100
WDEDGEKRIP LDVAEGDTVI YSKYGGTEIK YNGEEYLILS ARDVLAVVSK
Length:100
Mass (Da):10,804
Last modified:January 23, 2007 - v4
Checksum:iDE448187A56103FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161Q → E AA sequence (PubMed:1900061).Curated
Sequence conflicti95 – 995LAVVS → VGRRF in CAA32149 (PubMed:3056744).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13970 Genomic DNA. Translation: CAA32149.1.
M35389 Genomic DNA. Translation: AAA25365.1.
BX248333 Genomic DNA. Translation: CDO44723.1.
PIRiS01784. BVMY7B.
RefSeqiNP_857092.1. NC_002945.3.
WP_003418028.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO44723; CDO44723; Mb3452c.
GeneIDi1091031.
KEGGimbo:Mb3452c.
PATRICi18009318. VBIMycBov88188_3787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13970 Genomic DNA. Translation: CAA32149.1.
M35389 Genomic DNA. Translation: AAA25365.1.
BX248333 Genomic DNA. Translation: CDO44723.1.
PIRiS01784. BVMY7B.
RefSeqiNP_857092.1. NC_002945.3.
WP_003418028.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP15020.
SMRiP15020. Positions 2-100.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO44723; CDO44723; Mb3452c.
GeneIDi1091031.
KEGGimbo:Mb3452c.
PATRICi18009318. VBIMycBov88188_3787.

Phylogenomic databases

HOGENOMiHOG000133897.
KOiK04078.
OMAiEHESCCH.
OrthoDBiEOG6GFGSD.

Family and domain databases

Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Immunogenic protein MPB57 from Mycobacterium bovis BCG: molecular cloning, nucleotide sequence and expression."
    Yamaguchi R., Matsuo K., Yamazaki A., Nagai S., Terasaka K., Yamada T.
    FEBS Lett. 240:115-117(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-21.
    Strain: BCG.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.
  3. "Purification and characterization of major antigens from a Mycobacterium bovis culture filtrate."
    Fifis T., Costopoulos C., Radford A.J., Bacic A., Wood P.R.
    Infect. Immun. 59:800-807(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-20.
    Strain: AN-5.

Entry informationi

Entry nameiCH10_MYCBO
AccessioniPrimary (citable) accession number: P15020
Secondary accession number(s): X2BNN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: February 17, 2016
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.