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Protein

10 kDa chaperonin

Gene

groS

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa chaperonin
Alternative name(s):
GroES protein
Immunogenic protein MPB57
Protein Cpn10
Gene namesi
Name:groS
Synonyms:groES, mopB
Ordered Locus Names:BQ2027_MB3452C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001747852 – 10010 kDa chaperoninAdd BLAST99

Interactioni

Subunit structurei

Heptamer of 7 subunits arranged in a ring.By similarity

Structurei

3D structure databases

ProteinModelPortaliP15020.
SMRiP15020.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

HOGENOMiHOG000133897.
KOiK04078.
OMAiPGRIDDN.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiView protein in InterPro
IPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiView protein in Pfam
PF00166. Cpn10. 1 hit.
PRINTSiPR00297. CHAPERONIN10.
SMARTiView protein in SMART
SM00883. Cpn10. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiView protein in PROSITE
PS00681. CHAPERONINS_CPN10. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVNIKPLE DKILVQANEA ETTTASGLVI PDTAKEKPQE GTVVAVGPGR
60 70 80 90 100
WDEDGEKRIP LDVAEGDTVI YSKYGGTEIK YNGEEYLILS ARDVLAVVSK
Length:100
Mass (Da):10,804
Last modified:January 23, 2007 - v4
Checksum:iDE448187A56103FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16Q → E AA sequence (PubMed:1900061).Curated1
Sequence conflicti95 – 99LAVVS → VGRRF in CAA32149 (PubMed:3056744).Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13970 Genomic DNA. Translation: CAA32149.1.
M35389 Genomic DNA. Translation: AAA25365.1.
LT708304 Genomic DNA. Translation: SIU02080.1.
PIRiS01784. BVMY7B.
RefSeqiNP_857092.1. NC_002945.3.
WP_003418028.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO44723; CDO44723; Mb3452c.
GeneIDi29702387.
KEGGimbo:Mb3452c.
PATRICifig|233413.5.peg.3787.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCH10_MYCBO
AccessioniPrimary (citable) accession number: P15020
Secondary accession number(s): A0A1R3Y454, X2BNN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 125 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families