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P15019

- TAL1_YEAST

UniProt

P15019 - TAL1_YEAST

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Protein

Transaldolase

Gene

TAL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441Schiff-base intermediate with substrate1 Publication

GO - Molecular functioni

  1. sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Source: SGD

GO - Biological processi

  1. pentose-phosphate shunt Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciYEAST:YLR354C-MONOMER.
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:TAL1
Ordered Locus Names:YLR354C
ORF Names:L9638.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

SGDiS000004346. TAL1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 335334TransaldolasePRO_0000173574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP15019.
PaxDbiP15019.
PeptideAtlasiP15019.
PRIDEiP15019.

2D gel databases

SWISS-2DPAGEP15019.

Expressioni

Gene expression databases

GenevestigatoriP15019.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi31616. 42 interactions.
DIPiDIP-4980N.
IntActiP15019. 8 interactions.
MINTiMINT-559744.
STRINGi4932.YLR354C.

Structurei

3D structure databases

ProteinModelPortaliP15019.
SMRiP15019. Positions 12-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0176.
GeneTreeiENSGT00390000017361.
HOGENOMiHOG000281234.
InParanoidiP15019.
KOiK00616.
OMAiEAKFRWA.
OrthoDBiEOG7N905G.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00492. Transaldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR001585. Transaldolase.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00874. talAB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15019-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEPAQKKQK VANNSLEQLK ASGTVVVADT GDFGSIAKFQ PQDSTTNPSL
60 70 80 90 100
ILAAAKQPTY AKLIDVAVEY GKKHGKTTEE QVENAVDRLL VEFGKEILKI
110 120 130 140 150
VPGRVSTEVD ARLSFDTQAT IEKARHIIKL FEQEGVSKER VLIKIASTWE
160 170 180 190 200
GIQAAKELEE KDGIHCNLTL LFSFVQAVAC AEAQVTLISP FVGRILDWYK
210 220 230 240 250
SSTGKDYKGE ADPGVISVKK IYNYYKKYGY KTIVMGASFR STDEIKNLAG
260 270 280 290 300
VDYLTISPAL LDKLMNSTEP FPRVLDPVSA KKEAGDKISY ISDESKFRFD
310 320 330
LNEDAMATEK LSEGIRKFSA DIVTLFDLIE KKVTA
Length:335
Mass (Da):37,036
Last modified:January 23, 2007 - v4
Checksum:i2A3A96D80E22B157
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211I → M in CAA34078. (PubMed:2185015)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15953 Genomic DNA. Translation: CAA34078.1.
U19102 Genomic DNA. Translation: AAB67752.1.
X04969 Genomic DNA. Translation: CAA28644.1.
L37016 Genomic DNA. Translation: AAA64519.1.
BK006945 Genomic DNA. Translation: DAA09658.1.
PIRiS51462.
RefSeqiNP_013458.1. NM_001182243.1.

Genome annotation databases

EnsemblFungiiYLR354C; YLR354C; YLR354C.
GeneIDi851068.
KEGGisce:YLR354C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15953 Genomic DNA. Translation: CAA34078.1 .
U19102 Genomic DNA. Translation: AAB67752.1 .
X04969 Genomic DNA. Translation: CAA28644.1 .
L37016 Genomic DNA. Translation: AAA64519.1 .
BK006945 Genomic DNA. Translation: DAA09658.1 .
PIRi S51462.
RefSeqi NP_013458.1. NM_001182243.1.

3D structure databases

ProteinModelPortali P15019.
SMRi P15019. Positions 12-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31616. 42 interactions.
DIPi DIP-4980N.
IntActi P15019. 8 interactions.
MINTi MINT-559744.
STRINGi 4932.YLR354C.

2D gel databases

SWISS-2DPAGE P15019.

Proteomic databases

MaxQBi P15019.
PaxDbi P15019.
PeptideAtlasi P15019.
PRIDEi P15019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR354C ; YLR354C ; YLR354C .
GeneIDi 851068.
KEGGi sce:YLR354C.

Organism-specific databases

SGDi S000004346. TAL1.

Phylogenomic databases

eggNOGi COG0176.
GeneTreei ENSGT00390000017361.
HOGENOMi HOG000281234.
InParanoidi P15019.
KOi K00616.
OMAi EAKFRWA.
OrthoDBi EOG7N905G.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00414 .
BioCyci YEAST:YLR354C-MONOMER.

Miscellaneous databases

NextBioi 967708.
PROi P15019.

Gene expression databases

Genevestigatori P15019.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00492. Transaldolase_1.
InterProi IPR013785. Aldolase_TIM.
IPR001585. Transaldolase.
IPR004730. Transaldolase_1.
IPR018225. Transaldolase_AS.
[Graphical view ]
PANTHERi PTHR10683. PTHR10683. 1 hit.
Pfami PF00923. Transaldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00874. talAB. 1 hit.
PROSITEi PS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the structural gene for yeast transaldolase."
    Schaaff I., Hohmann S., Zimmermann F.K.
    Eur. J. Biochem. 188:597-603(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204510 / AB320.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The ILV5 gene of Saccharomyces cerevisiae is highly expressed."
    Petersen J.G.L., Holmberg S.
    Nucleic Acids Res. 14:9631-9651(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-97.
  5. Harkins H.A., Pringle J.R.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 263-335.
  6. "Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase."
    Miosga T., Schaaff-Gerstenschlaeger I., Franken E., Zimmermann F.K.
    Yeast 9:1241-1249(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVE SITE.
  7. "Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins."
    Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I., Kobayashi R., Schwender B., Volpe T., Anderson D.S., Mesquita-Fuentes R., Payne W.E.
    Electrophoresis 18:1347-1360(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT SER-2.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAL1_YEAST
AccessioniPrimary (citable) accession number: P15019
Secondary accession number(s): D6VYZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Two isoenzymes seem to be encoded by the same gene.
Present with 53000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3