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Protein

Transaldolase

Gene

TAL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Miscellaneous

Two isoenzymes seem to be encoded by the same gene.
Present with 53000 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (TAL1), Transaldolase NQM1 (NQM1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei144Schiff-base intermediate with substrate1 Publication1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • pentose-phosphate shunt Source: SGD

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

BioCyciYEAST:YLR354C-MONOMER
BRENDAi2.2.1.2 984
ReactomeiR-SCE-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-SCE-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:TAL1
Ordered Locus Names:YLR354C
ORF Names:L9638.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR354C
SGDiS000004346 TAL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001735742 – 335TransaldolaseAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP15019
PaxDbiP15019
PRIDEiP15019
TopDownProteomicsiP15019

2D gel databases

SWISS-2DPAGEiP15019

PTM databases

iPTMnetiP15019

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

WithEntry#Exp.IntActNotes
YGR043CE9P9A03EBI-18952,EBI-7074625From Saccharomyces cerevisiae.

Protein-protein interaction databases

BioGridi31616, 108 interactors
DIPiDIP-4980N
IntActiP15019, 26 interactors
MINTiP15019
STRINGi4932.YLR354C

Structurei

3D structure databases

ProteinModelPortaliP15019
SMRiP15019
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000017361
HOGENOMiHOG000281234
InParanoidiP15019
KOiK00616
OMAiMAFDKLH
OrthoDBiEOG092C3F92

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00492 Transaldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPAQKKQK VANNSLEQLK ASGTVVVADT GDFGSIAKFQ PQDSTTNPSL
60 70 80 90 100
ILAAAKQPTY AKLIDVAVEY GKKHGKTTEE QVENAVDRLL VEFGKEILKI
110 120 130 140 150
VPGRVSTEVD ARLSFDTQAT IEKARHIIKL FEQEGVSKER VLIKIASTWE
160 170 180 190 200
GIQAAKELEE KDGIHCNLTL LFSFVQAVAC AEAQVTLISP FVGRILDWYK
210 220 230 240 250
SSTGKDYKGE ADPGVISVKK IYNYYKKYGY KTIVMGASFR STDEIKNLAG
260 270 280 290 300
VDYLTISPAL LDKLMNSTEP FPRVLDPVSA KKEAGDKISY ISDESKFRFD
310 320 330
LNEDAMATEK LSEGIRKFSA DIVTLFDLIE KKVTA
Length:335
Mass (Da):37,036
Last modified:January 23, 2007 - v4
Checksum:i2A3A96D80E22B157
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221I → M in CAA34078 (PubMed:2185015).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15953 Genomic DNA Translation: CAA34078.1
U19102 Genomic DNA Translation: AAB67752.1
X04969 Genomic DNA Translation: CAA28644.1
L37016 Genomic DNA Translation: AAA64519.1
BK006945 Genomic DNA Translation: DAA09658.1
PIRiS51462
RefSeqiNP_013458.1, NM_001182243.1

Genome annotation databases

EnsemblFungiiYLR354C; YLR354C; YLR354C
GeneIDi851068
KEGGisce:YLR354C

Similar proteinsi

Entry informationi

Entry nameiTAL1_YEAST
AccessioniPrimary (citable) accession number: P15019
Secondary accession number(s): D6VYZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 169 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health