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P15018

- LIF_HUMAN

UniProt

P15018 - LIF_HUMAN

Protein

Leukemia inhibitory factor

Gene

LIF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. growth factor activity Source: BHF-UCL
    3. leukemia inhibitory factor receptor binding Source: BHF-UCL
    4. receptor binding Source: BHF-UCL
    5. RNA polymerase II transcription factor recruiting transcription factor activity Source: BHF-UCL

    GO - Biological processi

    1. blood vessel remodeling Source: Ensembl
    2. decidualization Source: Ensembl
    3. embryo implantation Source: Ensembl
    4. immune response Source: InterPro
    5. leukemia inhibitory factor signaling pathway Source: BHF-UCL
    6. lung alveolus development Source: Ensembl
    7. lung lobe morphogenesis Source: Ensembl
    8. lung vasculature development Source: Ensembl
    9. multicellular organismal development Source: ProtInc
    10. muscle organ morphogenesis Source: Ensembl
    11. negative regulation of cell proliferation Source: Ensembl
    12. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    13. negative regulation of hormone secretion Source: MGI
    14. negative regulation of meiosis Source: Ensembl
    15. neuron development Source: Ensembl
    16. positive regulation of astrocyte differentiation Source: Ensembl
    17. positive regulation of cell proliferation Source: BHF-UCL
    18. positive regulation of histone H3-K27 acetylation Source: BHF-UCL
    19. positive regulation of macrophage differentiation Source: MGI
    20. positive regulation of MAPK cascade Source: MGI
    21. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: BHF-UCL
    22. positive regulation of peptidyl-serine phosphorylation Source: MGI
    23. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: BHF-UCL
    24. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    25. positive regulation of protein localization to nucleus Source: BHF-UCL
    26. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    27. positive regulation of tyrosine phosphorylation of Stat1 protein Source: BHF-UCL
    28. positive regulation of tyrosine phosphorylation of Stat3 protein Source: BHF-UCL
    29. regulation of metanephric nephron tubule epithelial cell differentiation Source: BHF-UCL
    30. spongiotrophoblast differentiation Source: Ensembl
    31. stem cell maintenance Source: Ensembl
    32. transcription from RNA polymerase II promoter Source: GOC
    33. trophoblast giant cell differentiation Source: Ensembl
    34. tyrosine phosphorylation of Stat3 protein Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    SignaLinkiP15018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukemia inhibitory factor
    Short name:
    LIF
    Alternative name(s):
    Differentiation-stimulating factor
    Short name:
    D factor
    Melanoma-derived LPL inhibitor
    Short name:
    MLPLI
    INN: Emfilermin
    Gene namesi
    Name:LIF
    Synonyms:HILDA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:6596. LIF.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. extracellular space Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    In phase II clinical trial. The drug is being developed by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies (ART).

    Organism-specific databases

    PharmGKBiPA30370.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 202180Leukemia inhibitory factorPRO_0000017715Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi31 – 311N-linked (GlcNAc...)1 Publication
    Disulfide bondi34 ↔ 1561 Publication
    Disulfide bondi40 ↔ 1531 Publication
    Glycosylationi56 – 561N-linked (GlcNAc...)1 Publication
    Disulfide bondi82 ↔ 1851 Publication
    Glycosylationi85 – 851N-linked (GlcNAc...)1 Publication
    Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication
    Glycosylationi118 – 1181N-linked (GlcNAc...)1 Publication
    Glycosylationi138 – 1381N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP15018.
    PRIDEiP15018.

    Miscellaneous databases

    PMAP-CutDBP15018.

    Expressioni

    Gene expression databases

    BgeeiP15018.
    CleanExiHS_LIF.
    GenevestigatoriP15018.

    Organism-specific databases

    HPAiCAB025985.
    HPA018844.

    Interactioni

    Protein-protein interaction databases

    BioGridi110164. 1 interaction.
    DIPiDIP-5769N.
    IntActiP15018. 1 interaction.
    MINTiMINT-1352030.
    STRINGi9606.ENSP00000249075.

    Structurei

    Secondary structure

    1
    202
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi44 – 7027
    Turni72 – 776
    Helixi78 – 814
    Beta strandi82 – 843
    Beta strandi94 – 963
    Helixi98 – 12629
    Helixi131 – 15727
    Helixi177 – 19923

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EMRX-ray3.50A44-202[»]
    1PVHX-ray2.50B/D34-202[»]
    2Q7NX-ray4.00B/D23-202[»]
    ProteinModelPortaliP15018.
    SMRiP15018. Positions 23-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP15018.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LIF/OSM family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45686.
    HOGENOMiHOG000059647.
    HOVERGENiHBG006267.
    InParanoidiP15018.
    KOiK05419.
    OMAiSNLMNQI.
    OrthoDBiEOG7JX359.
    PhylomeDBiP15018.
    TreeFamiTF336245.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003624. Leukemia_IF.
    IPR001581. Leukemia_IF/oncostatin.
    IPR019827. Leukemia_IF/oncostatin_CS.
    [Graphical view]
    PANTHERiPTHR10633. PTHR10633. 1 hit.
    PfamiPF01291. LIF_OSM. 1 hit.
    [Graphical view]
    PRINTSiPR01883. LEUKAEMIAIF.
    SMARTiSM00080. LIF_OSM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00590. LIF_OSM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P15018-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVLAAGVVP LLLVLHWKHG AGSPLPITPV NATCAIRHPC HNNLMNQIRS    50
    QLAQLNGSAN ALFILYYTAQ GEPFPNNLDK LCGPNVTDFP PFHANGTEKA 100
    KLVELYRIVV YLGTSLGNIT RDQKILNPSA LSLHSKLNAT ADILRGLLSN 150
    VLCRLCSKYH VGHVDVTYGP DTSGKDVFQK KKLGCQLLGK YKQIIAVLAQ 200
    AF 202
    Length:202
    Mass (Da):22,008
    Last modified:April 1, 1990 - v1
    Checksum:i634CD10BFF67A217
    GO
    Isoform 2 (identifier: P15018-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         7-88: GVVPLLLVLH...DKLCGPNVTD → VHSPGGAVPQ...RHRRHPARPP
         89-202: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:88
    Mass (Da):9,563
    Checksum:iC27010E1B89B18E5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei7 – 8882GVVPL…PNVTD → VHSPGGAVPQQPGQAMWPQR DGLPALPRQRHGEGQAGGAV PHSRVPWHLPGQHHPGPEDP QPQCPQPPQQAQRHRRHPAR PP in isoform 2. 1 PublicationVSP_045551Add
    BLAST
    Alternative sequencei89 – 202114Missing in isoform 2. 1 PublicationVSP_045552Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13967 mRNA. Translation: CAA32147.1.
    M27053, M27052 Genomic DNA. Translation: AAA53188.1.
    AC004264 Genomic DNA. Translation: AAC05174.1.
    M63420 Genomic DNA. Translation: AAA51699.1.
    CN409468 mRNA. No translation available.
    AK315310 mRNA. Translation: BAG37714.1.
    CH471095 Genomic DNA. Translation: EAW59863.1.
    BC069540 mRNA. Translation: AAH69540.1.
    BC093733 mRNA. Translation: AAH93733.1.
    BC093735 mRNA. Translation: AAH93735.1.
    J03261 Genomic DNA. Translation: AAA59517.1.
    CCDSiCCDS13872.1. [P15018-1]
    CCDS58799.1. [P15018-2]
    PIRiB36282.
    RefSeqiNP_001244064.1. NM_001257135.1. [P15018-2]
    NP_002300.1. NM_002309.4. [P15018-1]
    XP_006724303.1. XM_006724240.1. [P15018-1]
    UniGeneiHs.2250.

    Genome annotation databases

    EnsembliENST00000249075; ENSP00000249075; ENSG00000128342. [P15018-1]
    ENST00000403987; ENSP00000384450; ENSG00000128342. [P15018-2]
    GeneIDi3976.
    KEGGihsa:3976.
    UCSCiuc003agz.3. human. [P15018-1]

    Polymorphism databases

    DMDMi126279.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Leukemia inhibitory factor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13967 mRNA. Translation: CAA32147.1 .
    M27053 , M27052 Genomic DNA. Translation: AAA53188.1 .
    AC004264 Genomic DNA. Translation: AAC05174.1 .
    M63420 Genomic DNA. Translation: AAA51699.1 .
    CN409468 mRNA. No translation available.
    AK315310 mRNA. Translation: BAG37714.1 .
    CH471095 Genomic DNA. Translation: EAW59863.1 .
    BC069540 mRNA. Translation: AAH69540.1 .
    BC093733 mRNA. Translation: AAH93733.1 .
    BC093735 mRNA. Translation: AAH93735.1 .
    J03261 Genomic DNA. Translation: AAA59517.1 .
    CCDSi CCDS13872.1. [P15018-1 ]
    CCDS58799.1. [P15018-2 ]
    PIRi B36282.
    RefSeqi NP_001244064.1. NM_001257135.1. [P15018-2 ]
    NP_002300.1. NM_002309.4. [P15018-1 ]
    XP_006724303.1. XM_006724240.1. [P15018-1 ]
    UniGenei Hs.2250.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EMR X-ray 3.50 A 44-202 [» ]
    1PVH X-ray 2.50 B/D 34-202 [» ]
    2Q7N X-ray 4.00 B/D 23-202 [» ]
    ProteinModelPortali P15018.
    SMRi P15018. Positions 23-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110164. 1 interaction.
    DIPi DIP-5769N.
    IntActi P15018. 1 interaction.
    MINTi MINT-1352030.
    STRINGi 9606.ENSP00000249075.

    Polymorphism databases

    DMDMi 126279.

    Proteomic databases

    PaxDbi P15018.
    PRIDEi P15018.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249075 ; ENSP00000249075 ; ENSG00000128342 . [P15018-1 ]
    ENST00000403987 ; ENSP00000384450 ; ENSG00000128342 . [P15018-2 ]
    GeneIDi 3976.
    KEGGi hsa:3976.
    UCSCi uc003agz.3. human. [P15018-1 ]

    Organism-specific databases

    CTDi 3976.
    GeneCardsi GC22M030636.
    HGNCi HGNC:6596. LIF.
    HPAi CAB025985.
    HPA018844.
    MIMi 159540. gene.
    neXtProti NX_P15018.
    PharmGKBi PA30370.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45686.
    HOGENOMi HOG000059647.
    HOVERGENi HBG006267.
    InParanoidi P15018.
    KOi K05419.
    OMAi SNLMNQI.
    OrthoDBi EOG7JX359.
    PhylomeDBi P15018.
    TreeFami TF336245.

    Enzyme and pathway databases

    SignaLinki P15018.

    Miscellaneous databases

    EvolutionaryTracei P15018.
    GeneWikii Leukemia_inhibitory_factor.
    GenomeRNAii 3976.
    NextBioi 15584.
    PMAP-CutDB P15018.
    PROi P15018.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15018.
    CleanExi HS_LIF.
    Genevestigatori P15018.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003624. Leukemia_IF.
    IPR001581. Leukemia_IF/oncostatin.
    IPR019827. Leukemia_IF/oncostatin_CS.
    [Graphical view ]
    PANTHERi PTHR10633. PTHR10633. 1 hit.
    Pfami PF01291. LIF_OSM. 1 hit.
    [Graphical view ]
    PRINTSi PR01883. LEUKAEMIAIF.
    SMARTi SM00080. LIF_OSM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00590. LIF_OSM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells."
      Moreau J.-F., Donaldson D.D., Bennett F., Witek-Giannotti J., Clark S.C., Wong G.G.
      Nature 336:690-692(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Genomic cloning and heterologous expression of human differentiation-stimulating factor."
      Lowe D.G., Nunes W., Bombara M., McCabe S., Ranges G.E., Henzel W., Tomida M., Yamamoto-Yamaguchi Y., Hozumi M., Goeddel D.V.
      DNA 8:351-359(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
      Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y., Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J., Stanton L.W.
      Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryonic stem cell.
    4. "Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions."
      Stahl J., Gearing D.P., Willson T.A., Brown M.A., King J.A., Gough N.M.
      J. Biol. Chem. 265:8833-8841(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    9. "Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor."
      Gough N.M., Gearing D.P., King J.A., Willson T.A., Hilton D.J., Nicola N.A., Metcalf D.
      Proc. Natl. Acad. Sci. U.S.A. 85:2623-2627(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-202.
    10. "Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia."
      Mori M., Yamaguchi K., Abe K.
      Biochem. Biophys. Res. Commun. 160:1085-1092(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-39.
    11. "Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor."
      Schmelzer C.H., Harris R.J., Butler D., Yedinak C.M., Wagner K.L., Burton L.E.
      Arch. Biochem. Biophys. 302:484-489(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, GLYCOSYLATION AT ASN-31; ASN-56; ASN-85; ASN-95; ASN-118 AND ASN-138.
    12. "Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130."
      Boulanger M.J., Bankovich A.J., Kortemme T., Baker D., Garcia K.C.
      Mol. Cell 12:577-589(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 34-202 IN COMPLEX WITH IL6ST.
    13. "An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor."
      Huyton T., Zhang J.G., Luo C.S., Lou M.Z., Hilton D.J., Nicola N.A., Garrett T.P.
      Proc. Natl. Acad. Sci. U.S.A. 104:12737-12742(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 23-202 IN COMPLEX WITH MOUSE LIFR.

    Entry informationi

    Entry nameiLIF_HUMAN
    AccessioniPrimary (citable) accession number: P15018
    Secondary accession number(s): B2RCW7, B5MC23, Q52LZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 155 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3