P15000 (ST_POVBA) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 18, 2012.
Version 52.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Small t antigen Short name=ST Short name=ST-AG |
| Organism | BK polyomavirus (strain AS) (BKPyV) [Complete proteome] |
| Taxonomic identifier | 10631 [NCBI] |
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Polyomaviridae › Polyomavirus |
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 172 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Promotes efficient viral genome replication by accelerating both G1 and S phase progression of the cell cycle. Inhibits host PP2A by binding to the A subunit, thereby displacing lower affinity regulatory B subunit. Inactivation of PP2A in turn results in the transactivation of cyclin A and cyclin D1 promoters. Late during the infection cycle, ST may induce dephosphorylation of host MTOR, leading to the inhibition of cap-dependent translation. May establish and maintain high levels of viral genomes during persistent infection in cell culture By similarity. |
| Subunit structure | Interacts with host PPP2R1A; the interaction inhibits PP2A activity By similarity. |
| Subcellular location | Host cytoplasm. Host nucleus By similarity. |
| Domain | The common region of ST and LT proteins comprises the J domain. This domain is essential for multiple viral activities, including virion assembly, viral DNA replication, transformation and transcriptional activation. This domain is also required for cyclin A-transactivating activity of ST By similarity. |
| Sequence similarities | Contains 1 J domain. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Small t antigen (identifier: P15000-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Large T antigen (identifier: P14999-1) The sequence of this isoform can be found in the external entry P14999. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 172 | 172 | Small t antigen | PRO_0000115052 | |||||
Regions | |||||||||
| Domain | 12 – 75 | 64 | J | ||||||
| Zinc finger | 101 – 114 | 14 | C4-type; atypical | ||||||
| Zinc finger | 120 – 141 | 22 | H1C3-type; atypical | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine; by host By similarity | ||||||
Sequences
| ||||||||||||||||||||||||
References
| [1] | "Nucleotide sequence of the human polyomavirus AS virus, an antigenic variant of BK virus." Tavis J.E., Walker D.L., Gardner S.D., Frisque R.J. J. Virol. 63:901-911(1989) [PubMed: 2536111] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M23122 Genomic DNA. Translation: AAA46883.1. |
| PIR | TVVPSS. B33278. |
3D structure databases | |
| ProteinModelPortal | P15000. |
| SMR | P15000. Positions 1-170. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| Gene3D | G3DSA:1.10.287.110. DnaJ_N. 1 hit. |
| InterPro | IPR001623. DnaJ_N. IPR003354. Papo_T_antigen. [Graphical view] |
| Pfam | PF00226. DnaJ. 1 hit. PF02380. Papo_T_antigen. 1 hit. [Graphical view] |
| SMART | SM00271. DnaJ. 1 hit. [Graphical view] |
| SUPFAM | SSF46565. DnaJ_N. 1 hit. |
| PROSITE | PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ST_POVBA | ||||||||
| Accession | Primary (citable) accession number: P15000 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |