Reviewed,
UniProtKB/Swiss-Prot P14998 (AGNO_POVBA)
Last modified
January 19, 2010.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (1) |
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Names and origin
| Protein names | Recommended name: Agnoprotein Alternative name(s): Agno |
| Organism | BK polyomavirus (strain AS) (BKPyV) [Complete proteome] |
| Taxonomic identifier | 10631 [NCBI] |
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Polyomaviridae › Polyomavirus |
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 74 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Alters the structure of the nuclear envelope by interacting with host CBX5 and disrupting CBX5 association with LBR. Involved in the perinuclear-nuclear localization of the capsid protein VP1 during virion assembly and maturation. May contribute to viral genome transcription and translation of viral late proteins. Plays an important role in the release of progeny virions from infected cells and in viral propagation By similarity. |
| Subunit structure | Interacts with VP1 By similarity. Interacts with Large T antigen By similarity. Interacts with small t antigen By similarity. |
| Subcellular location | Host cytoplasm. Host nucleus By similarity. |
| Post-translational modification | Phosphorylated by host kinase. Phosphorylation segregates agnoprotein in cytoplasm, whereas unphosphorylated agnoprotein migrate to the nucleus By similarity. |
| Sequence similarities | Belongs to the polyomavirus agnoprotein family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Host-virus interaction |
| Cellular component | Host cytoplasm Host nucleus |
| Coding sequence diversity | Alternative initiation Alternative splicing |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing and alternative initiation. [Align] [Select] | ||||||
| Isoform Agno (identifier: P14998-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: Produced by alternative initiation of the leader region. | ||||||
| Isoform VP2 (identifier: P14997-1) The sequence of this isoform can be found in the external entry P14997-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Isoform VP3 (identifier: P14997-2) The sequence of this isoform can be found in the external entry P14997-2. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. | ||||||
| Note: Produced by alternative initiation at Met-120 of isoform VP2. | ||||||
| Isoform VP1 (identifier: P14996-1) The sequence of this isoform can be found in the external entry P14996-1. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 74 | 74 | Agnoprotein | PRO_0000115030 | |||||
Amino acid modifications | |||||||||
| Modified residue | 15 | 1 | Phosphoserine; by host By similarity | ||||||
| Modified residue | 19 | 1 | Phosphoserine; by host By similarity | ||||||
| Modified residue | 29 | 1 | Phosphothreonine; by host By similarity | ||||||
Sequences
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References
| [1] | "Nucleotide sequence of the human polyomavirus AS virus, an antigenic variant of BK virus." Tavis J.E., Walker D.L., Gardner S.D., Frisque R.J. J. Virol. 63:901-911(1989) [PubMed: 2536111] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M23122 Genomic DNA. Translation: AAA46879.1. |
| PIR | DNVPAS. C33278. |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR002643. Polyoma_agno. [Graphical view] |
| Pfam | PF01736. Polyoma_agno. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AGNO_POVBA | ||||||||
| Accession | Primary (citable) accession number: P14998 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
